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Downregulation of S6 Kinase and Hedgehog-Gli1 by Inhibition of Fatty Acid Synthase in AML with FLT3-ITD Mutation.

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Title: Downregulation of S6 Kinase and Hedgehog-Gli1 by Inhibition of Fatty Acid Synthase in AML with FLT3-ITD Mutation.
Authors: Kebenko M; Hubertus Wald Tumorzentrum, Department of Oncology-Hematology, Bone Marrow Transplantation and Pneumology, University Cancer Center, 20246 Hamburg, Germany.; Clinic for Hematology and Oncology, University Hospital Schleswig-Holstein Campus, 23562 Lübeck, Germany., Zhuang R; Institute of Biochemistry and Signal Transduction, Center for Experimental Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Hoffer K; Department of Radiobiology & Radiation Oncology, UCCH Kinomics Core Facility, University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Worthmann A; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Horn S; Research Department Cell and Gene Therapy, Department of Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Kriegs M; Department of Radiobiology & Radiation Oncology, UCCH Kinomics Core Facility, University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Vorwerk J; Clinic for Hematology and Oncology, University Hospital Schleswig-Holstein Campus, 23562 Lübeck, Germany., von Bubnoff N; Clinic for Hematology and Oncology, University Hospital Schleswig-Holstein Campus, 23562 Lübeck, Germany., Khandanpour C; Clinic for Hematology and Oncology, University Hospital Schleswig-Holstein Campus, 23562 Lübeck, Germany., Gebauer N; Clinic for Hematology and Oncology, University Hospital Schleswig-Holstein Campus, 23562 Lübeck, Germany., Gorantla SP; Clinic for Hematology and Oncology, University Hospital Schleswig-Holstein Campus, 23562 Lübeck, Germany., Fiedler W; Hubertus Wald Tumorzentrum, Department of Oncology-Hematology, Bone Marrow Transplantation and Pneumology, University Cancer Center, 20246 Hamburg, Germany., Bokemeyer C; Hubertus Wald Tumorzentrum, Department of Oncology-Hematology, Bone Marrow Transplantation and Pneumology, University Cancer Center, 20246 Hamburg, Germany., Jücker M; Institute of Biochemistry and Signal Transduction, Center for Experimental Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Source: International journal of molecular sciences [Int J Mol Sci] 2025 Jun 14; Vol. 26 (12). Date of Electronic Publication: 2025 Jun 14.
Publication Type: Journal Article
Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Downregulation of S6 Kinase and Hedgehog-Gli1 by Inhibition of Fatty Acid Synthase in AML with FLT3-ITD Mutation.
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  Data: <searchLink fieldCode="AU" term="%22Kebenko+M%22">Kebenko M</searchLink>; Hubertus Wald Tumorzentrum, Department of Oncology-Hematology, Bone Marrow Transplantation and Pneumology, University Cancer Center, 20246 Hamburg, Germany.; Clinic for Hematology and Oncology, University Hospital Schleswig-Holstein Campus, 23562 Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Zhuang+R%22">Zhuang R</searchLink>; Institute of Biochemistry and Signal Transduction, Center for Experimental Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Hoffer+K%22">Hoffer K</searchLink>; Department of Radiobiology & Radiation Oncology, UCCH Kinomics Core Facility, University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Worthmann+A%22">Worthmann A</searchLink>; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Horn+S%22">Horn S</searchLink>; Research Department Cell and Gene Therapy, Department of Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Kriegs+M%22">Kriegs M</searchLink>; Department of Radiobiology & Radiation Oncology, UCCH Kinomics Core Facility, University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Vorwerk+J%22">Vorwerk J</searchLink>; Clinic for Hematology and Oncology, University Hospital Schleswig-Holstein Campus, 23562 Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22von+Bubnoff+N%22">von Bubnoff N</searchLink>; Clinic for Hematology and Oncology, University Hospital Schleswig-Holstein Campus, 23562 Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Khandanpour+C%22">Khandanpour C</searchLink>; Clinic for Hematology and Oncology, University Hospital Schleswig-Holstein Campus, 23562 Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Gebauer+N%22">Gebauer N</searchLink>; Clinic for Hematology and Oncology, University Hospital Schleswig-Holstein Campus, 23562 Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Gorantla+SP%22">Gorantla SP</searchLink>; Clinic for Hematology and Oncology, University Hospital Schleswig-Holstein Campus, 23562 Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Fiedler+W%22">Fiedler W</searchLink>; Hubertus Wald Tumorzentrum, Department of Oncology-Hematology, Bone Marrow Transplantation and Pneumology, University Cancer Center, 20246 Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Bokemeyer+C%22">Bokemeyer C</searchLink>; Hubertus Wald Tumorzentrum, Department of Oncology-Hematology, Bone Marrow Transplantation and Pneumology, University Cancer Center, 20246 Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Jücker+M%22">Jücker M</searchLink>; Institute of Biochemistry and Signal Transduction, Center for Experimental Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
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