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Hepatoprotective action of Sonchus oleraceus against paracetamol-induced toxicity via Nrf2/KEAP-1/HO-1 pathway in relation to its metabolite fingerprint and in silico studies.

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Title: Hepatoprotective action of Sonchus oleraceus against paracetamol-induced toxicity via Nrf2/KEAP-1/HO-1 pathway in relation to its metabolite fingerprint and in silico studies.
Authors: Abdelhameed MF; Pharmacology Department, Medical Research and Clinical Studies Institute, National Research Centre, 33 El Bohouth St., Dokki, Cairo, Egypt., El-Baset MA; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, United States of America., Khattab AR; Pharmacognosy Department, College of Pharmacy, Arab Academy for Science, Technology and Maritime Transport, Alexandria, Egypt., Taher RF; Department of Natural Compounds Chemistry, National Research Center, 33 El Bohouth St., Dokki, Giza, Egypt., El-Saied MA; Department of Pathology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt., Abd Elkarim AS; Chemistry of Tanning Materials and Leather Technology Department, National Research Centre, 33 El Bohouth St., Dokki, Giza, Egypt., Essa AF; Department of Natural Compounds Chemistry, National Research Center, 33 El Bohouth St., Dokki, Giza, Egypt., El-Rashedy AA; Chemistry of Natural and Microbial Products Department, National Research Centre, 33 El Bohouth St., Dokki, Giza, Egypt.; Department Organic and Medicinal Chemistry, Faculty of Pharmacy, University of Sadat City, Menoufia, Egypt., Farag MA; Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.; Faculty of Healthcare, Saxony Egypt University (SEU), Badr city, Egypt., Imagawa H; Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima, 770, Japan., Elshamy AI; Department of Natural Compounds Chemistry, National Research Center, 33 El Bohouth St., Dokki, Giza, Egypt.; Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima, 770, Japan., Abd-ElGawad AM; Plant Production Department, College of Food & Agriculture Sciences, King Saud University, P.O. Box 2460, Riyadh 11451, Saudi Arabia.
Source: PloS one [PLoS One] 2025 Jun 26; Vol. 20 (6), pp. e0325782. Date of Electronic Publication: 2025 Jun 26 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="JN" term="%22101285081%22">PloS one</searchLink> [PLoS One] 2025 Jun 26; Vol. 20 (6), pp. e0325782. <i>Date of Electronic Publication: </i>2025 Jun 26 (<i>Print Publication: </i>2025).
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