Identifying and exploiting combinatorial synthetic lethality by characterizing adaptive kinome rewiring of EGFRvIII-driven glioblastoma.
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| Title: | Identifying and exploiting combinatorial synthetic lethality by characterizing adaptive kinome rewiring of EGFRvIII-driven glioblastoma. |
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| Authors: | Lin B; Medical Scientist Training Program, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.; Division of Neuropathology, Department of Pathology, Heersink School of Medicine, University of Alabama at Birmingham, WTI 410C, 1824 6th Avenue South, Birmingham, AL, 35294-3300, USA., Shelton AK; Division of Neuropathology, Department of Pathology, Heersink School of Medicine, University of Alabama at Birmingham, WTI 410C, 1824 6th Avenue South, Birmingham, AL, 35294-3300, USA., Smithberger E; Division of Neuropathology, Department of Pathology, Heersink School of Medicine, University of Alabama at Birmingham, WTI 410C, 1824 6th Avenue South, Birmingham, AL, 35294-3300, USA., Ziebro J; Division of Neuropathology, Department of Pathology, Heersink School of Medicine, University of Alabama at Birmingham, WTI 410C, 1824 6th Avenue South, Birmingham, AL, 35294-3300, USA., Skinner KR; Division of Neuropathology, Department of Pathology, Heersink School of Medicine, University of Alabama at Birmingham, WTI 410C, 1824 6th Avenue South, Birmingham, AL, 35294-3300, USA., Bash RE; Division of Neuropathology, Department of Pathology, Heersink School of Medicine, University of Alabama at Birmingham, WTI 410C, 1824 6th Avenue South, Birmingham, AL, 35294-3300, USA., Kirkman R; Division of Neuropathology, Department of Pathology, Heersink School of Medicine, University of Alabama at Birmingham, WTI 410C, 1824 6th Avenue South, Birmingham, AL, 35294-3300, USA., Stamper A; Division of Neuropathology, Department of Pathology, Heersink School of Medicine, University of Alabama at Birmingham, WTI 410C, 1824 6th Avenue South, Birmingham, AL, 35294-3300, USA., Butler M; Department of Biology, University of North Carolina, Chapel Hill, NC, USA., Flores A; University of North Carolina School of Medicine, Chapel Hill, NC, USA., Angus SP; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA., East MP; Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC, USA., Cloughesy TF; Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Nathanson DA; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Berens ME; Cancer and Cell Biology Division, Translational Genomics Research Institute, Phoenix, AZ, USA., Sarkaria JN; Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA., Binder ZA; Department of Neurosurgery and Glioblastoma Translational Center of Excellence, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., O'Rourke DM; Department of Neurosurgery and Glioblastoma Translational Center of Excellence, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Howton TC; Department of Cell, Developmental and Integrative Biology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Lasseigne BN; Department of Cell, Developmental and Integrative Biology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.; O'Neal Comprehensive Cancer Center, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.; Comprehensive Neuroscience Center, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Willey CD; O'Neal Comprehensive Cancer Center, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.; Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, AL, USA., Johnson GL; Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC, USA., Hjelmeland AB; Department of Cell, Developmental and Integrative Biology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.; O'Neal Comprehensive Cancer Center, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.; Comprehensive Neuroscience Center, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Furnari FB; Department of Medicine, Division of Regenerative Medicine, University of California, San Diego, San Diego, CA, USA., Miller CR; Division of Neuropathology, Department of Pathology, Heersink School of Medicine, University of Alabama at Birmingham, WTI 410C, 1824 6th Avenue South, Birmingham, AL, 35294-3300, USA. ryanmiller@uabmc.edu.; O'Neal Comprehensive Cancer Center, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA. ryanmiller@uabmc.edu.; Comprehensive Neuroscience Center, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA. ryanmiller@uabmc.edu. |
| Source: | Acta neuropathologica communications [Acta Neuropathol Commun] 2025 Jun 28; Vol. 13 (1), pp. 143. Date of Electronic Publication: 2025 Jun 28. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. |
| Journal Info: | Publisher: BioMed Central Country of Publication: England NLM ID: 101610673 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-5960 (Electronic) Linking ISSN: 20515960 NLM ISO Abbreviation: Acta Neuropathol Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2051-5960 |
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| DOI: | 10.1186/s40478-025-02068-y |
