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Identifying and exploiting combinatorial synthetic lethality by characterizing adaptive kinome rewiring of EGFRvIII-driven glioblastoma.

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Title: Identifying and exploiting combinatorial synthetic lethality by characterizing adaptive kinome rewiring of EGFRvIII-driven glioblastoma.
Authors: Lin B; Medical Scientist Training Program, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.; Division of Neuropathology, Department of Pathology, Heersink School of Medicine, University of Alabama at Birmingham, WTI 410C, 1824 6th Avenue South, Birmingham, AL, 35294-3300, USA., Shelton AK; Division of Neuropathology, Department of Pathology, Heersink School of Medicine, University of Alabama at Birmingham, WTI 410C, 1824 6th Avenue South, Birmingham, AL, 35294-3300, USA., Smithberger E; Division of Neuropathology, Department of Pathology, Heersink School of Medicine, University of Alabama at Birmingham, WTI 410C, 1824 6th Avenue South, Birmingham, AL, 35294-3300, USA., Ziebro J; Division of Neuropathology, Department of Pathology, Heersink School of Medicine, University of Alabama at Birmingham, WTI 410C, 1824 6th Avenue South, Birmingham, AL, 35294-3300, USA., Skinner KR; Division of Neuropathology, Department of Pathology, Heersink School of Medicine, University of Alabama at Birmingham, WTI 410C, 1824 6th Avenue South, Birmingham, AL, 35294-3300, USA., Bash RE; Division of Neuropathology, Department of Pathology, Heersink School of Medicine, University of Alabama at Birmingham, WTI 410C, 1824 6th Avenue South, Birmingham, AL, 35294-3300, USA., Kirkman R; Division of Neuropathology, Department of Pathology, Heersink School of Medicine, University of Alabama at Birmingham, WTI 410C, 1824 6th Avenue South, Birmingham, AL, 35294-3300, USA., Stamper A; Division of Neuropathology, Department of Pathology, Heersink School of Medicine, University of Alabama at Birmingham, WTI 410C, 1824 6th Avenue South, Birmingham, AL, 35294-3300, USA., Butler M; Department of Biology, University of North Carolina, Chapel Hill, NC, USA., Flores A; University of North Carolina School of Medicine, Chapel Hill, NC, USA., Angus SP; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA., East MP; Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC, USA., Cloughesy TF; Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Nathanson DA; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Berens ME; Cancer and Cell Biology Division, Translational Genomics Research Institute, Phoenix, AZ, USA., Sarkaria JN; Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA., Binder ZA; Department of Neurosurgery and Glioblastoma Translational Center of Excellence, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., O'Rourke DM; Department of Neurosurgery and Glioblastoma Translational Center of Excellence, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Howton TC; Department of Cell, Developmental and Integrative Biology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Lasseigne BN; Department of Cell, Developmental and Integrative Biology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.; O'Neal Comprehensive Cancer Center, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.; Comprehensive Neuroscience Center, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Willey CD; O'Neal Comprehensive Cancer Center, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.; Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, AL, USA., Johnson GL; Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC, USA., Hjelmeland AB; Department of Cell, Developmental and Integrative Biology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.; O'Neal Comprehensive Cancer Center, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.; Comprehensive Neuroscience Center, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Furnari FB; Department of Medicine, Division of Regenerative Medicine, University of California, San Diego, San Diego, CA, USA., Miller CR; Division of Neuropathology, Department of Pathology, Heersink School of Medicine, University of Alabama at Birmingham, WTI 410C, 1824 6th Avenue South, Birmingham, AL, 35294-3300, USA. ryanmiller@uabmc.edu.; O'Neal Comprehensive Cancer Center, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA. ryanmiller@uabmc.edu.; Comprehensive Neuroscience Center, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA. ryanmiller@uabmc.edu.
Source: Acta neuropathologica communications [Acta Neuropathol Commun] 2025 Jun 28; Vol. 13 (1), pp. 143. Date of Electronic Publication: 2025 Jun 28.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101610673 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-5960 (Electronic) Linking ISSN: 20515960 NLM ISO Abbreviation: Acta Neuropathol Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Identifying and exploiting combinatorial synthetic lethality by characterizing adaptive kinome rewiring of EGFRvIII-driven glioblastoma.
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  Data: <searchLink fieldCode="AU" term="%22Lin+B%22">Lin B</searchLink>; Medical Scientist Training Program, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.; Division of Neuropathology, Department of Pathology, Heersink School of Medicine, University of Alabama at Birmingham, WTI 410C, 1824 6th Avenue South, Birmingham, AL, 35294-3300, USA.<br /><searchLink fieldCode="AU" term="%22Shelton+AK%22">Shelton AK</searchLink>; Division of Neuropathology, Department of Pathology, Heersink School of Medicine, University of Alabama at Birmingham, WTI 410C, 1824 6th Avenue South, Birmingham, AL, 35294-3300, USA.<br /><searchLink fieldCode="AU" term="%22Smithberger+E%22">Smithberger E</searchLink>; Division of Neuropathology, Department of Pathology, Heersink School of Medicine, University of Alabama at Birmingham, WTI 410C, 1824 6th Avenue South, Birmingham, AL, 35294-3300, USA.<br /><searchLink fieldCode="AU" term="%22Ziebro+J%22">Ziebro J</searchLink>; Division of Neuropathology, Department of Pathology, Heersink School of Medicine, University of Alabama at Birmingham, WTI 410C, 1824 6th Avenue South, Birmingham, AL, 35294-3300, USA.<br /><searchLink fieldCode="AU" term="%22Skinner+KR%22">Skinner KR</searchLink>; Division of Neuropathology, Department of Pathology, Heersink School of Medicine, University of Alabama at Birmingham, WTI 410C, 1824 6th Avenue South, Birmingham, AL, 35294-3300, USA.<br /><searchLink fieldCode="AU" term="%22Bash+RE%22">Bash RE</searchLink>; Division of Neuropathology, Department of Pathology, Heersink School of Medicine, University of Alabama at Birmingham, WTI 410C, 1824 6th Avenue South, Birmingham, AL, 35294-3300, USA.<br /><searchLink fieldCode="AU" term="%22Kirkman+R%22">Kirkman R</searchLink>; Division of Neuropathology, Department of Pathology, Heersink School of Medicine, University of Alabama at Birmingham, WTI 410C, 1824 6th Avenue South, Birmingham, AL, 35294-3300, USA.<br /><searchLink fieldCode="AU" term="%22Stamper+A%22">Stamper A</searchLink>; Division of Neuropathology, Department of Pathology, Heersink School of Medicine, University of Alabama at Birmingham, WTI 410C, 1824 6th Avenue South, Birmingham, AL, 35294-3300, USA.<br /><searchLink fieldCode="AU" term="%22Butler+M%22">Butler M</searchLink>; Department of Biology, University of North Carolina, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Flores+A%22">Flores A</searchLink>; University of North Carolina School of Medicine, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Angus+SP%22">Angus SP</searchLink>; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22East+MP%22">East MP</searchLink>; Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Cloughesy+TF%22">Cloughesy TF</searchLink>; Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Nathanson+DA%22">Nathanson DA</searchLink>; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Berens+ME%22">Berens ME</searchLink>; Cancer and Cell Biology Division, Translational Genomics Research Institute, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Sarkaria+JN%22">Sarkaria JN</searchLink>; Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Binder+ZA%22">Binder ZA</searchLink>; Department of Neurosurgery and Glioblastoma Translational Center of Excellence, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22O'Rourke+DM%22">O'Rourke DM</searchLink>; Department of Neurosurgery and Glioblastoma Translational Center of Excellence, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Howton+TC%22">Howton TC</searchLink>; Department of Cell, Developmental and Integrative Biology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22Lasseigne+BN%22">Lasseigne BN</searchLink>; Department of Cell, Developmental and Integrative Biology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.; O'Neal Comprehensive Cancer Center, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.; Comprehensive Neuroscience Center, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22Willey+CD%22">Willey CD</searchLink>; O'Neal Comprehensive Cancer Center, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.; Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22Johnson+GL%22">Johnson GL</searchLink>; Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Hjelmeland+AB%22">Hjelmeland AB</searchLink>; Department of Cell, Developmental and Integrative Biology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.; O'Neal Comprehensive Cancer Center, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.; Comprehensive Neuroscience Center, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22Furnari+FB%22">Furnari FB</searchLink>; Department of Medicine, Division of Regenerative Medicine, University of California, San Diego, San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Miller+CR%22">Miller CR</searchLink>; Division of Neuropathology, Department of Pathology, Heersink School of Medicine, University of Alabama at Birmingham, WTI 410C, 1824 6th Avenue South, Birmingham, AL, 35294-3300, USA. ryanmiller@uabmc.edu.; O'Neal Comprehensive Cancer Center, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA. ryanmiller@uabmc.edu.; Comprehensive Neuroscience Center, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA. ryanmiller@uabmc.edu.
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  Data: <searchLink fieldCode="JN" term="%22101610673%22">Acta neuropathologica communications</searchLink> [Acta Neuropathol Commun] 2025 Jun 28; Vol. 13 (1), pp. 143. <i>Date of Electronic Publication: </i>2025 Jun 28.
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