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Trend in the use of biological drugs in pediatric patients with immune-mediated inflammatory diseases: Insight from the large-scale Italian VALORE project.

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Title: Trend in the use of biological drugs in pediatric patients with immune-mediated inflammatory diseases: Insight from the large-scale Italian VALORE project.
Authors: Bellitto C; Department of Diagnostics and Public Health, University of Verona, Verona, Italy., Ingrasciotta Y; Department of Diagnostics and Public Health, University of Verona, Verona, Italy., Soardo F; Department of Diagnostics and Public Health, University of Verona, Verona, Italy., Spini A; Department of Diagnostics and Public Health, University of Verona, Verona, Italy., L'Abbate L; Department of Diagnostics and Public Health, University of Verona, Verona, Italy., Pellegrini G; Department of Diagnostics and Public Health, University of Verona, Verona, Italy., Mathieu C; University of Bordeaux, INSERM, BPH, team AHeaD, Bordeaux, France., Carollo M; Department of Diagnostics and Public Health, University of Verona, Verona, Italy., Tuccori M; Department of Diagnostics and Public Health, University of Verona, Verona, Italy., Leoni O; Lombardy Regional Epidemiologic Observatory, Milan, Italy., Mazzone A; Azienda Regionale per l'Innovazione e gli Acquisti, S.p.A, Milan, Italy., Ancona D; Centro Regionale Farmacovigilanza, Regione Puglia, Italy., Stella P; Centro Regionale Farmacovigilanza, Regione Puglia, Italy., Cavazzana A; Azienda Zero, Regione Veneto, Italy., Scapin A; Azienda Zero, Regione Veneto, Italy., Lopes S; Department of Epidemiology, Lazio Regional Health Service, Rome, Italy., Belleudi V; Department of Epidemiology, Lazio Regional Health Service, Rome, Italy., Ledda S; Regione Autonoma della Sardegna, Cagliari, Italy., Carta P; Regione Autonoma della Sardegna, Cagliari, Italy., Rossi P; Friuli-Venezia Giulia Regional Center of Pharmacovigilance, Trieste, Italy., Ejlli L; Friuli-Venezia Giulia Regional Center of Pharmacovigilance, Trieste, Italy., Sapigni E; Emilia-Romagna Regional Center of Pharmacovigilance, Bologna, Italy., Puccini A; Emilia-Romagna Regional Center of Pharmacovigilance, Bologna, Italy., Scarpelli RF; Dipartimento Salute e Welfare, Calabria Region, Catanzaro, Italy., De Sarro G; University 'Magna Graciae' of Catanzaro, Catanzaro, Italy., Gini R; Agenzia Regionale di Sanità Toscana, Florence, Italy., Allotta A; Epidemiologic Observatory of the Sicily Regional Health Service, Palermo, Italy., Pollina SA; Epidemiologic Observatory of the Sicily Regional Health Service, Palermo, Italy., Bucaneve G; Umbria Regional Centre of Pharmacovigilance, Perugia, Italy., Mangano AMP; Agenzia Regionale Sanitaria della, Ancona, Regione Marche, Italy., Balducci F; Agenzia Regionale Sanitaria della, Ancona, Regione Marche, Italy., Sorrentino C; Regional Pharmaceutical Unit, Abruzzo Region, Italy., Senesi I; Abruzzo Regional Centre of Pharmacovigilance, Teramo, Italy., Trama U; Coordination of the Regional Health System, General Directorate for Health Protection, Naples, Italy., Bernardi FF; Coordination of the Regional Health System, General Directorate for Health Protection, Naples, Italy; Department of Experimental Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy., Da Cas R; Italian National Institute of Health, Rome, Italy., Costa G; Hospital Pharmacy Unit, Azienda Provinciale Per i Servizi Sanitari, Trento, Italy., Urru SAM; Hospital Pharmacy Unit, Azienda Provinciale Per i Servizi Sanitari, Trento, Italy., Campomori A; Hospital Pharmacy Unit, Azienda Provinciale Per i Servizi Sanitari, Trento, Italy., Spila Alegiani S; Italian National Institute of Health, Rome, Italy., Massari M; Italian National Institute of Health, Rome, Italy., Gallizzi R; Paediatric Unit, Department of Health Science, Magna Graecia University of Catanzaro, Catanzaro, Italy., Trifirò G; Department of Diagnostics and Public Health, University of Verona, Verona, Italy. Electronic address: gianluca.trifiro@univr.it.
Source: Pharmacological research [Pharmacol Res] 2025 Aug; Vol. 218, pp. 107843. Date of Electronic Publication: 2025 Jun 28.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8907422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-1186 (Electronic) Linking ISSN: 10436618 NLM ISO Abbreviation: Pharmacol Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Trend in the use of biological drugs in pediatric patients with immune-mediated inflammatory diseases: Insight from the large-scale Italian VALORE project.
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  Data: <searchLink fieldCode="AU" term="%22Bellitto+C%22">Bellitto C</searchLink>; Department of Diagnostics and Public Health, University of Verona, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Ingrasciotta+Y%22">Ingrasciotta Y</searchLink>; Department of Diagnostics and Public Health, University of Verona, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Soardo+F%22">Soardo F</searchLink>; Department of Diagnostics and Public Health, University of Verona, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Spini+A%22">Spini A</searchLink>; Department of Diagnostics and Public Health, University of Verona, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22L'Abbate+L%22">L'Abbate L</searchLink>; Department of Diagnostics and Public Health, University of Verona, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Pellegrini+G%22">Pellegrini G</searchLink>; Department of Diagnostics and Public Health, University of Verona, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Mathieu+C%22">Mathieu C</searchLink>; University of Bordeaux, INSERM, BPH, team AHeaD, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Carollo+M%22">Carollo M</searchLink>; Department of Diagnostics and Public Health, University of Verona, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Tuccori+M%22">Tuccori M</searchLink>; Department of Diagnostics and Public Health, University of Verona, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Leoni+O%22">Leoni O</searchLink>; Lombardy Regional Epidemiologic Observatory, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Mazzone+A%22">Mazzone A</searchLink>; Azienda Regionale per l'Innovazione e gli Acquisti, S.p.A, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Ancona+D%22">Ancona D</searchLink>; Centro Regionale Farmacovigilanza, Regione Puglia, Italy.<br /><searchLink fieldCode="AU" term="%22Stella+P%22">Stella P</searchLink>; Centro Regionale Farmacovigilanza, Regione Puglia, Italy.<br /><searchLink fieldCode="AU" term="%22Cavazzana+A%22">Cavazzana A</searchLink>; Azienda Zero, Regione Veneto, Italy.<br /><searchLink fieldCode="AU" term="%22Scapin+A%22">Scapin A</searchLink>; Azienda Zero, Regione Veneto, Italy.<br /><searchLink fieldCode="AU" term="%22Lopes+S%22">Lopes S</searchLink>; Department of Epidemiology, Lazio Regional Health Service, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Belleudi+V%22">Belleudi V</searchLink>; Department of Epidemiology, Lazio Regional Health Service, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Ledda+S%22">Ledda S</searchLink>; Regione Autonoma della Sardegna, Cagliari, Italy.<br /><searchLink fieldCode="AU" term="%22Carta+P%22">Carta P</searchLink>; Regione Autonoma della Sardegna, Cagliari, Italy.<br /><searchLink fieldCode="AU" term="%22Rossi+P%22">Rossi P</searchLink>; Friuli-Venezia Giulia Regional Center of Pharmacovigilance, Trieste, Italy.<br /><searchLink fieldCode="AU" term="%22Ejlli+L%22">Ejlli L</searchLink>; Friuli-Venezia Giulia Regional Center of Pharmacovigilance, Trieste, Italy.<br /><searchLink fieldCode="AU" term="%22Sapigni+E%22">Sapigni E</searchLink>; Emilia-Romagna Regional Center of Pharmacovigilance, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Puccini+A%22">Puccini A</searchLink>; Emilia-Romagna Regional Center of Pharmacovigilance, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Scarpelli+RF%22">Scarpelli RF</searchLink>; Dipartimento Salute e Welfare, Calabria Region, Catanzaro, Italy.<br /><searchLink fieldCode="AU" term="%22De+Sarro+G%22">De Sarro G</searchLink>; University 'Magna Graciae' of Catanzaro, Catanzaro, Italy.<br /><searchLink fieldCode="AU" term="%22Gini+R%22">Gini R</searchLink>; Agenzia Regionale di Sanità Toscana, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Allotta+A%22">Allotta A</searchLink>; Epidemiologic Observatory of the Sicily Regional Health Service, Palermo, Italy.<br /><searchLink fieldCode="AU" term="%22Pollina+SA%22">Pollina SA</searchLink>; Epidemiologic Observatory of the Sicily Regional Health Service, Palermo, Italy.<br /><searchLink fieldCode="AU" term="%22Bucaneve+G%22">Bucaneve G</searchLink>; Umbria Regional Centre of Pharmacovigilance, Perugia, Italy.<br /><searchLink fieldCode="AU" term="%22Mangano+AMP%22">Mangano AMP</searchLink>; Agenzia Regionale Sanitaria della, Ancona, Regione Marche, Italy.<br /><searchLink fieldCode="AU" term="%22Balducci+F%22">Balducci F</searchLink>; Agenzia Regionale Sanitaria della, Ancona, Regione Marche, Italy.<br /><searchLink fieldCode="AU" term="%22Sorrentino+C%22">Sorrentino C</searchLink>; Regional Pharmaceutical Unit, Abruzzo Region, Italy.<br /><searchLink fieldCode="AU" term="%22Senesi+I%22">Senesi I</searchLink>; Abruzzo Regional Centre of Pharmacovigilance, Teramo, Italy.<br /><searchLink fieldCode="AU" term="%22Trama+U%22">Trama U</searchLink>; Coordination of the Regional Health System, General Directorate for Health Protection, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Bernardi+FF%22">Bernardi FF</searchLink>; Coordination of the Regional Health System, General Directorate for Health Protection, Naples, Italy; Department of Experimental Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Da+Cas+R%22">Da Cas R</searchLink>; Italian National Institute of Health, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Costa+G%22">Costa G</searchLink>; Hospital Pharmacy Unit, Azienda Provinciale Per i Servizi Sanitari, Trento, Italy.<br /><searchLink fieldCode="AU" term="%22Urru+SAM%22">Urru SAM</searchLink>; Hospital Pharmacy Unit, Azienda Provinciale Per i Servizi Sanitari, Trento, Italy.<br /><searchLink fieldCode="AU" term="%22Campomori+A%22">Campomori A</searchLink>; Hospital Pharmacy Unit, Azienda Provinciale Per i Servizi Sanitari, Trento, Italy.<br /><searchLink fieldCode="AU" term="%22Spila+Alegiani+S%22">Spila Alegiani S</searchLink>; Italian National Institute of Health, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Massari+M%22">Massari M</searchLink>; Italian National Institute of Health, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Gallizzi+R%22">Gallizzi R</searchLink>; Paediatric Unit, Department of Health Science, Magna Graecia University of Catanzaro, Catanzaro, Italy.<br /><searchLink fieldCode="AU" term="%22Trifirò+G%22">Trifirò G</searchLink>; Department of Diagnostics and Public Health, University of Verona, Verona, Italy. Electronic address: gianluca.trifiro@univr.it.
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