Sphingosine simultaneously inhibits nuclear import and activates PP2A by binding importins and PPP2R1A.
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| Title: | Sphingosine simultaneously inhibits nuclear import and activates PP2A by binding importins and PPP2R1A. |
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| Authors: | Jayashankar V; Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA, 92697, USA., Kubiniok P; Department of Chemistry, Université de Montréal, Montreal, QC, H3C 3J7, Canada.; Institute for Research in Immunology and Cancer, Université de Montréal, Montreal, QC, H3C 3J7, Canada., McCracken AN; Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA, 92697, USA., Gentry RG; Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA, 92697, USA., Eckenstein KH; Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA, 92697, USA., Sernissi L; Department of Chemistry, Université de Montréal, Montreal, QC, H3C 3J7, Canada., Vece V; Department of Chemistry, Université de Montréal, Montreal, QC, H3C 3J7, Canada., Garsi JB; Department of Chemistry, Université de Montréal, Montreal, QC, H3C 3J7, Canada., Valles SY; Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA, 92697, USA., Jung S; Department of Biological Chemistry, University of California Irvine School of Medicine, Irvine, CA, 92697, USA., Hoffman NC; Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA, 92697, USA., Perrochon AS; Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA, 92697, USA., Selwan EM; Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA, 92697, USA., Finicle BT; Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA, 92697, USA., Pitman M; Department of Pharmaceutical Sciences, University of California Irvine School of Pharmacy and Pharmaceutical Sciences, Irvine, CA, 92697, USA., Lin D; Department of Biological Chemistry, University of California Irvine School of Medicine, Irvine, CA, 92697, USA., Bonneil É; Institute for Research in Immunology and Cancer, Université de Montréal, Montreal, QC, H3C 3J7, Canada., Xu R; Department of Medicine, Renaissance School of Medicine, The State University of New York, Stony Brook, NY, 11794, USA., Mao C; Department of Medicine, Renaissance School of Medicine, The State University of New York, Stony Brook, NY, 11794, USA., Kaiser P; Department of Biological Chemistry, University of California Irvine School of Medicine, Irvine, CA, 92697, USA., Fruman DA; Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA, 92697, USA., Mobley D; Department of Pharmaceutical Sciences, University of California Irvine School of Pharmacy and Pharmaceutical Sciences, Irvine, CA, 92697, USA., Jang C; Department of Biological Chemistry, University of California Irvine School of Medicine, Irvine, CA, 92697, USA., Hanessian S; Department of Chemistry, Université de Montréal, Montreal, QC, H3C 3J7, Canada. stephen.hanessian@umontreal.ca.; Department of Pharmaceutical Sciences, University of California Irvine School of Pharmacy and Pharmaceutical Sciences, Irvine, CA, 92697, USA. stephen.hanessian@umontreal.ca., Thibault P; Department of Chemistry, Université de Montréal, Montreal, QC, H3C 3J7, Canada. pierre.thibault@umontreal.ca.; Institute for Research in Immunology and Cancer, Université de Montréal, Montreal, QC, H3C 3J7, Canada. pierre.thibault@umontreal.ca., Edinger AL; Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA, 92697, USA. aedinger@uci.edu.; Department of Pharmaceutical Sciences, University of California Irvine School of Pharmacy and Pharmaceutical Sciences, Irvine, CA, 92697, USA. aedinger@uci.edu. |
| Source: | The EMBO journal [EMBO J] 2025 Aug; Vol. 44 (16), pp. 4473-4498. Date of Electronic Publication: 2025 Jun 30. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1460-2075 |
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| DOI: | 10.1038/s44318-025-00490-5 |
