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Sphingosine simultaneously inhibits nuclear import and activates PP2A by binding importins and PPP2R1A.

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Title: Sphingosine simultaneously inhibits nuclear import and activates PP2A by binding importins and PPP2R1A.
Authors: Jayashankar V; Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA, 92697, USA., Kubiniok P; Department of Chemistry, Université de Montréal, Montreal, QC, H3C 3J7, Canada.; Institute for Research in Immunology and Cancer, Université de Montréal, Montreal, QC, H3C 3J7, Canada., McCracken AN; Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA, 92697, USA., Gentry RG; Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA, 92697, USA., Eckenstein KH; Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA, 92697, USA., Sernissi L; Department of Chemistry, Université de Montréal, Montreal, QC, H3C 3J7, Canada., Vece V; Department of Chemistry, Université de Montréal, Montreal, QC, H3C 3J7, Canada., Garsi JB; Department of Chemistry, Université de Montréal, Montreal, QC, H3C 3J7, Canada., Valles SY; Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA, 92697, USA., Jung S; Department of Biological Chemistry, University of California Irvine School of Medicine, Irvine, CA, 92697, USA., Hoffman NC; Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA, 92697, USA., Perrochon AS; Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA, 92697, USA., Selwan EM; Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA, 92697, USA., Finicle BT; Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA, 92697, USA., Pitman M; Department of Pharmaceutical Sciences, University of California Irvine School of Pharmacy and Pharmaceutical Sciences, Irvine, CA, 92697, USA., Lin D; Department of Biological Chemistry, University of California Irvine School of Medicine, Irvine, CA, 92697, USA., Bonneil É; Institute for Research in Immunology and Cancer, Université de Montréal, Montreal, QC, H3C 3J7, Canada., Xu R; Department of Medicine, Renaissance School of Medicine, The State University of New York, Stony Brook, NY, 11794, USA., Mao C; Department of Medicine, Renaissance School of Medicine, The State University of New York, Stony Brook, NY, 11794, USA., Kaiser P; Department of Biological Chemistry, University of California Irvine School of Medicine, Irvine, CA, 92697, USA., Fruman DA; Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA, 92697, USA., Mobley D; Department of Pharmaceutical Sciences, University of California Irvine School of Pharmacy and Pharmaceutical Sciences, Irvine, CA, 92697, USA., Jang C; Department of Biological Chemistry, University of California Irvine School of Medicine, Irvine, CA, 92697, USA., Hanessian S; Department of Chemistry, Université de Montréal, Montreal, QC, H3C 3J7, Canada. stephen.hanessian@umontreal.ca.; Department of Pharmaceutical Sciences, University of California Irvine School of Pharmacy and Pharmaceutical Sciences, Irvine, CA, 92697, USA. stephen.hanessian@umontreal.ca., Thibault P; Department of Chemistry, Université de Montréal, Montreal, QC, H3C 3J7, Canada. pierre.thibault@umontreal.ca.; Institute for Research in Immunology and Cancer, Université de Montréal, Montreal, QC, H3C 3J7, Canada. pierre.thibault@umontreal.ca., Edinger AL; Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA, 92697, USA. aedinger@uci.edu.; Department of Pharmaceutical Sciences, University of California Irvine School of Pharmacy and Pharmaceutical Sciences, Irvine, CA, 92697, USA. aedinger@uci.edu.
Source: The EMBO journal [EMBO J] 2025 Aug; Vol. 44 (16), pp. 4473-4498. Date of Electronic Publication: 2025 Jun 30.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Jayashankar+V%22">Jayashankar V</searchLink>; Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA, 92697, USA.<br /><searchLink fieldCode="AU" term="%22Kubiniok+P%22">Kubiniok P</searchLink>; Department of Chemistry, Université de Montréal, Montreal, QC, H3C 3J7, Canada.; Institute for Research in Immunology and Cancer, Université de Montréal, Montreal, QC, H3C 3J7, Canada.<br /><searchLink fieldCode="AU" term="%22McCracken+AN%22">McCracken AN</searchLink>; Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA, 92697, USA.<br /><searchLink fieldCode="AU" term="%22Gentry+RG%22">Gentry RG</searchLink>; Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA, 92697, USA.<br /><searchLink fieldCode="AU" term="%22Eckenstein+KH%22">Eckenstein KH</searchLink>; Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA, 92697, USA.<br /><searchLink fieldCode="AU" term="%22Sernissi+L%22">Sernissi L</searchLink>; Department of Chemistry, Université de Montréal, Montreal, QC, H3C 3J7, Canada.<br /><searchLink fieldCode="AU" term="%22Vece+V%22">Vece V</searchLink>; Department of Chemistry, Université de Montréal, Montreal, QC, H3C 3J7, Canada.<br /><searchLink fieldCode="AU" term="%22Garsi+JB%22">Garsi JB</searchLink>; Department of Chemistry, Université de Montréal, Montreal, QC, H3C 3J7, Canada.<br /><searchLink fieldCode="AU" term="%22Valles+SY%22">Valles SY</searchLink>; Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA, 92697, USA.<br /><searchLink fieldCode="AU" term="%22Jung+S%22">Jung S</searchLink>; Department of Biological Chemistry, University of California Irvine School of Medicine, Irvine, CA, 92697, USA.<br /><searchLink fieldCode="AU" term="%22Hoffman+NC%22">Hoffman NC</searchLink>; Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA, 92697, USA.<br /><searchLink fieldCode="AU" term="%22Perrochon+AS%22">Perrochon AS</searchLink>; 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Department of Chemistry, Université de Montréal, Montreal, QC, H3C 3J7, Canada. stephen.hanessian@umontreal.ca.; Department of Pharmaceutical Sciences, University of California Irvine School of Pharmacy and Pharmaceutical Sciences, Irvine, CA, 92697, USA. stephen.hanessian@umontreal.ca.<br /><searchLink fieldCode="AU" term="%22Thibault+P%22">Thibault P</searchLink>; Department of Chemistry, Université de Montréal, Montreal, QC, H3C 3J7, Canada. pierre.thibault@umontreal.ca.; Institute for Research in Immunology and Cancer, Université de Montréal, Montreal, QC, H3C 3J7, Canada. pierre.thibault@umontreal.ca.<br /><searchLink fieldCode="AU" term="%22Edinger+AL%22">Edinger AL</searchLink>; Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA, 92697, USA. aedinger@uci.edu.; Department of Pharmaceutical Sciences, University of California Irvine School of Pharmacy and Pharmaceutical Sciences, Irvine, CA, 92697, USA. aedinger@uci.edu.
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