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Gut microbiota-derived GlcNAc-MurNAc is a TLR4 agonist that protects the host gut.

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Title: Gut microbiota-derived GlcNAc-MurNAc is a TLR4 agonist that protects the host gut.
Authors: Li C; School of Chemistry, Chemical Engineering and Biotechnology (CCEB), Nanyang Technological University, 21 Nanyang Link, Singapore, 637371, Singapore., Adamson C; School of Chemistry, Chemical Engineering and Biotechnology (CCEB), Nanyang Technological University, 21 Nanyang Link, Singapore, 637371, Singapore., Ng AWR; School of Chemistry, Chemical Engineering and Biotechnology (CCEB), Nanyang Technological University, 21 Nanyang Link, Singapore, 637371, Singapore., Liang Y; School of Chemistry, Chemical Engineering and Biotechnology (CCEB), Nanyang Technological University, 21 Nanyang Link, Singapore, 637371, Singapore., Hong Z; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), 61 Biopolis Drive, Singapore, 138673, Singapore., Loh JT; School of Biological Sciences (SBS), Nanyang Technological University, 60 Nanyang Drive, Singapore, 637551, Singapore., Ng SK; Lee Kong Chian School of Medicine, Nanyang Technological University, 11 Mandalay Road, Singapore, 308232, Singapore.; Department of Gastroenterology and Hepatology, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore, 308433, Singapore., Kwan JMC; School of Chemistry, Chemical Engineering and Biotechnology (CCEB), Nanyang Technological University, 21 Nanyang Link, Singapore, 637371, Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University, 11 Mandalay Road, Singapore, 308232, Singapore., Feng S; School of Chemistry, Chemical Engineering and Biotechnology (CCEB), Nanyang Technological University, 21 Nanyang Link, Singapore, 637371, Singapore., Ng EWL; School of Chemistry, Chemical Engineering and Biotechnology (CCEB), Nanyang Technological University, 21 Nanyang Link, Singapore, 637371, Singapore., Nair S; School of Biological Sciences (SBS), Nanyang Technological University, 60 Nanyang Drive, Singapore, 637551, Singapore., Ruedl C; School of Biological Sciences (SBS), Nanyang Technological University, 60 Nanyang Drive, Singapore, 637551, Singapore., Wong SH; Lee Kong Chian School of Medicine, Nanyang Technological University, 11 Mandalay Road, Singapore, 308232, Singapore.; Department of Gastroenterology and Hepatology, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore, 308433, Singapore., Lam KP; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove, Singapore, 138648, Singapore., Qiao Y; School of Chemistry, Chemical Engineering and Biotechnology (CCEB), Nanyang Technological University, 21 Nanyang Link, Singapore, 637371, Singapore. yuan.qiao@ntu.edu.sg.
Source: Nature communications [Nat Commun] 2025 Jul 01; Vol. 16 (1), pp. 5577. Date of Electronic Publication: 2025 Jul 01.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Li+C%22">Li C</searchLink>; School of Chemistry, Chemical Engineering and Biotechnology (CCEB), Nanyang Technological University, 21 Nanyang Link, Singapore, 637371, Singapore.<br /><searchLink fieldCode="AU" term="%22Adamson+C%22">Adamson C</searchLink>; School of Chemistry, Chemical Engineering and Biotechnology (CCEB), Nanyang Technological University, 21 Nanyang Link, Singapore, 637371, Singapore.<br /><searchLink fieldCode="AU" term="%22Ng+AWR%22">Ng AWR</searchLink>; School of Chemistry, Chemical Engineering and Biotechnology (CCEB), Nanyang Technological University, 21 Nanyang Link, Singapore, 637371, Singapore.<br /><searchLink fieldCode="AU" term="%22Liang+Y%22">Liang Y</searchLink>; School of Chemistry, Chemical Engineering and Biotechnology (CCEB), Nanyang Technological University, 21 Nanyang Link, Singapore, 637371, Singapore.<br /><searchLink fieldCode="AU" term="%22Hong+Z%22">Hong Z</searchLink>; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), 61 Biopolis Drive, Singapore, 138673, Singapore.<br /><searchLink fieldCode="AU" term="%22Loh+JT%22">Loh JT</searchLink>; School of Biological Sciences (SBS), Nanyang Technological University, 60 Nanyang Drive, Singapore, 637551, Singapore.<br /><searchLink fieldCode="AU" term="%22Ng+SK%22">Ng SK</searchLink>; Lee Kong Chian School of Medicine, Nanyang Technological University, 11 Mandalay Road, Singapore, 308232, Singapore.; Department of Gastroenterology and Hepatology, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore, 308433, Singapore.<br /><searchLink fieldCode="AU" term="%22Kwan+JMC%22">Kwan JMC</searchLink>; School of Chemistry, Chemical Engineering and Biotechnology (CCEB), Nanyang Technological University, 21 Nanyang Link, Singapore, 637371, Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University, 11 Mandalay Road, Singapore, 308232, Singapore.<br /><searchLink fieldCode="AU" term="%22Feng+S%22">Feng S</searchLink>; School of Chemistry, Chemical Engineering and Biotechnology (CCEB), Nanyang Technological University, 21 Nanyang Link, Singapore, 637371, Singapore.<br /><searchLink fieldCode="AU" term="%22Ng+EWL%22">Ng EWL</searchLink>; School of Chemistry, Chemical Engineering and Biotechnology (CCEB), Nanyang Technological University, 21 Nanyang Link, Singapore, 637371, Singapore.<br /><searchLink fieldCode="AU" term="%22Nair+S%22">Nair S</searchLink>; School of Biological Sciences (SBS), Nanyang Technological University, 60 Nanyang Drive, Singapore, 637551, Singapore.<br /><searchLink fieldCode="AU" term="%22Ruedl+C%22">Ruedl C</searchLink>; School of Biological Sciences (SBS), Nanyang Technological University, 60 Nanyang Drive, Singapore, 637551, Singapore.<br /><searchLink fieldCode="AU" term="%22Wong+SH%22">Wong SH</searchLink>; Lee Kong Chian School of Medicine, Nanyang Technological University, 11 Mandalay Road, Singapore, 308232, Singapore.; Department of Gastroenterology and Hepatology, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore, 308433, Singapore.<br /><searchLink fieldCode="AU" term="%22Lam+KP%22">Lam KP</searchLink>; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove, Singapore, 138648, Singapore.<br /><searchLink fieldCode="AU" term="%22Qiao+Y%22">Qiao Y</searchLink>; School of Chemistry, Chemical Engineering and Biotechnology (CCEB), Nanyang Technological University, 21 Nanyang Link, Singapore, 637371, Singapore. yuan.qiao@ntu.edu.sg.
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