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Human cancer-targeted immunity via transgenic hematopoietic stem cell progeny.

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Title: Human cancer-targeted immunity via transgenic hematopoietic stem cell progeny.
Authors: Nowicki TS; Division of Pediatric Hematology-Oncology, Department of Pediatrics, University of California Los Angeles, Los Angeles, CA, USA. tnowicki@mednet.ucla.edu.; Department of Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles, Los Angeles, CA, USA. tnowicki@mednet.ucla.edu.; Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, CA, USA. tnowicki@mednet.ucla.edu.; Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, University of California Los Angeles, Los Angeles, CA, USA. tnowicki@mednet.ucla.edu.; Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA, USA. tnowicki@mednet.ucla.edu.; David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA. tnowicki@mednet.ucla.edu., Deen NNA; Division of Hematology-Oncology, Department of Medicine, University of California Los Angeles, Los Angeles, CA, USA., Peters CW; Division of Pediatric Hematology-Oncology, Department of Pediatrics, University of California Los Angeles, Los Angeles, CA, USA., Comin-Anduix B; Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, CA, USA.; Ahmanson Translational Theranostics Division, Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, CA, USA.; Division of Surgical Oncology, Department of Surgery, University of California Los Angeles, Los Angeles, CA, USA., Medina E; Division of Hematology-Oncology, Department of Medicine, University of California Los Angeles, Los Angeles, CA, USA., Puig-Saus C; Department of Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles, Los Angeles, CA, USA.; Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, CA, USA.; Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, University of California Los Angeles, Los Angeles, CA, USA.; Division of Surgical Oncology, Department of Surgery, University of California Los Angeles, Los Angeles, CA, USA.; Parker Institute for Cancer Immunotherapy, UCLA, Los Angeles, CA, USA., Carretero IB; Division of Hematology-Oncology, Department of Medicine, University of California Los Angeles, Los Angeles, CA, USA., Kaplan-Lefko P; Division of Hematology-Oncology, Department of Medicine, University of California Los Angeles, Los Angeles, CA, USA., Macabali MH; Division of Hematology-Oncology, Department of Medicine, University of California Los Angeles, Los Angeles, CA, USA., Garcilazo IP; Division of Hematology-Oncology, Department of Medicine, University of California Los Angeles, Los Angeles, CA, USA., Chen D; Division of Hematology-Oncology, Department of Medicine, University of California Los Angeles, Los Angeles, CA, USA., Pang J; Division of Hematology-Oncology, Department of Medicine, University of California Los Angeles, Los Angeles, CA, USA., Berent-Maoz B; Division of Hematology-Oncology, Department of Medicine, University of California Los Angeles, Los Angeles, CA, USA., Haile S; Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, CA, USA.; David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.; Division of Hematology-Oncology, Department of Medicine, University of California Los Angeles, Los Angeles, CA, USA., Rodriguez J; David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA., Kawakami M; Division of Pediatric Hematology-Oncology, Department of Pediatrics, University of California Los Angeles, Los Angeles, CA, USA., Kidd CK; Division of Pediatric Hematology-Oncology, Department of Pediatrics, University of California Los Angeles, Los Angeles, CA, USA., Champhekar A; Division of Hematology-Oncology, Department of Medicine, University of California Los Angeles, Los Angeles, CA, USA., Carlucci G; Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, CA, USA., Vega-Crespo A; Division of Hematology-Oncology, Department of Medicine, University of California Los Angeles, Los Angeles, CA, USA., Chmielowski B; Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, CA, USA.; Division of Hematology-Oncology, Department of Medicine, University of California Los Angeles, Los Angeles, CA, USA., Singh A; Division of Hematology-Oncology, Department of Medicine, University of California Los Angeles, Los Angeles, CA, USA., Federman N; Division of Pediatric Hematology-Oncology, Department of Pediatrics, University of California Los Angeles, Los Angeles, CA, USA.; Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, CA, USA.; Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, University of California Los Angeles, Los Angeles, CA, USA.; David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.; Department of Orthopaedic Surgery, University of California Los Angeles, Los Angeles, CA, USA., Schiller GM; Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, CA, USA.; Division of Hematology-Oncology, Department of Medicine, University of California Los Angeles, Los Angeles, CA, USA., Larson SJ; Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, CA, USA.; Division of Hematology-Oncology, Department of Medicine, University of California Los Angeles, Los Angeles, CA, USA., Allen-Auerbach M; David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.; Ahmanson Translational Theranostics Division, Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, CA, USA., Klomhaus AM; Department of Medicine Statistics Core, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA., Zack J; Department of Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles, Los Angeles, CA, USA.; Division of Hematology-Oncology, Department of Medicine, University of California Los Angeles, Los Angeles, CA, USA., Baltimore D; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA., Yang L; Department of Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles, Los Angeles, CA, USA.; Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, CA, USA.; Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, University of California Los Angeles, Los Angeles, CA, USA.; Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA, USA., Kohn DB; Division of Pediatric Hematology-Oncology, Department of Pediatrics, University of California Los Angeles, Los Angeles, CA, USA.; Department of Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles, Los Angeles, CA, USA., Witte ON; Department of Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles, Los Angeles, CA, USA.; Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, CA, USA.; Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, University of California Los Angeles, Los Angeles, CA, USA.; Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA, USA.; David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.; Parker Institute for Cancer Immunotherapy, UCLA, Los Angeles, CA, USA., Ribas A; Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, CA, USA.; Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, University of California Los Angeles, Los Angeles, CA, USA.; David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.; Division of Hematology-Oncology, Department of Medicine, University of California Los Angeles, Los Angeles, CA, USA.; Division of Surgical Oncology, Department of Surgery, University of California Los Angeles, Los Angeles, CA, USA.; Parker Institute for Cancer Immunotherapy, UCLA, Los Angeles, CA, USA.; Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, CA, USA.
Source: Nature communications [Nat Commun] 2025 Jul 01; Vol. 16 (1), pp. 5599. Date of Electronic Publication: 2025 Jul 01.
Publication Type: Journal Article; Clinical Trial, Phase I
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-025-60816-z