Copy number flexibility facilitates heteroresistance to increasing antibiotic pressure and threatens the beta-lactam pipeline.
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| Title: | Copy number flexibility facilitates heteroresistance to increasing antibiotic pressure and threatens the beta-lactam pipeline. |
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| Authors: | Choby JE; Emory Antibiotic Resistance Center; Emory University School of Medicine, Atlanta, GA, USA.; Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.; Emory Vaccine Center, Atlanta, GA, USA., Ozturk T; Emory Antibiotic Resistance Center; Emory University School of Medicine, Atlanta, GA, USA.; Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.; Emory Vaccine Center, Atlanta, GA, USA., Abbott CN; Emory Antibiotic Resistance Center; Emory University School of Medicine, Atlanta, GA, USA.; Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.; Emory Vaccine Center, Atlanta, GA, USA., Nnabuife C; Verna and Marrs McLean Department of Biochemistry and Molecular Pharmacology, Baylor College of Medicine, Houston, TX, USA., Colquhoun JM; Emory Antibiotic Resistance Center; Emory University School of Medicine, Atlanta, GA, USA.; Department of Microbiology and Immunology, Emory University, Atlanta, GA, USA.; Research Service, Atlanta VA Medical Center, Decatur, GA, USA., Satola SW; Emory Antibiotic Resistance Center; Emory University School of Medicine, Atlanta, GA, USA.; Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.; Georgia Emerging Infections Program, Atlanta, GA, USA., Rather PN; Emory Antibiotic Resistance Center; Emory University School of Medicine, Atlanta, GA, USA.; Department of Microbiology and Immunology, Emory University, Atlanta, GA, USA.; Research Service, Atlanta VA Medical Center, Decatur, GA, USA., Palzkill T; Verna and Marrs McLean Department of Biochemistry and Molecular Pharmacology, Baylor College of Medicine, Houston, TX, USA., Weiss DS; Emory Antibiotic Resistance Center; Emory University School of Medicine, Atlanta, GA, USA. david.weiss@emory.edu.; Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA. david.weiss@emory.edu.; Emory Vaccine Center, Atlanta, GA, USA. david.weiss@emory.edu. |
| Source: | Nature communications [Nat Commun] 2025 Jul 01; Vol. 16 (1), pp. 5721. Date of Electronic Publication: 2025 Jul 01. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-025-60828-9 |
