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Merging the computational design of chimeric type I polyketide synthases with enzymatic pathways for chemical biosynthesis.

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Title: Merging the computational design of chimeric type I polyketide synthases with enzymatic pathways for chemical biosynthesis.
Authors: Chainani Y; Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL, USA.; Center for Synthetic Biology, Evanston, IL, USA.; Joint BioEnergy Institute, Emeryville, CA, USA.; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Diaz J; Joint BioEnergy Institute, Emeryville, CA, USA.; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Guilarte-Silva M; Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL, USA.; Center for Synthetic Biology, Evanston, IL, USA., Blay V; Joint BioEnergy Institute, Emeryville, CA, USA.; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Zhang Q; Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL, USA., Sprague W; Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL, USA., Tyo KEJ; Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL, USA.; Center for Synthetic Biology, Evanston, IL, USA., Broadbelt LJ; Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL, USA.; Center for Synthetic Biology, Evanston, IL, USA.; Joint BioEnergy Institute, Emeryville, CA, USA.; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Mukhopadhyay A; Joint BioEnergy Institute, Emeryville, CA, USA.; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Keasling JD; Joint BioEnergy Institute, Emeryville, CA, USA.; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.; QB3, University of California, Berkeley, CA, USA.; Department of Chemical and Biomolecular Engineering, University of California, Berkeley, CA, USA.; Department of Bioengineering, University of California, Berkeley, CA, USA.; Center for Biosustainability, Danish Technical University, Lynby, Denmark., Martin HG; Joint BioEnergy Institute, Emeryville, CA, USA.; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.; BCAM, Basque Center for Applied Mathematics, Bilbao, Spain.; DOE Agile BioFoundry, Emeryville, CA, USA., Backman TWH; Joint BioEnergy Institute, Emeryville, CA, USA. tbackman@lbl.gov.; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA. tbackman@lbl.gov.
Source: Nature communications [Nat Commun] 2025 Jul 01; Vol. 16 (1), pp. 5787. Date of Electronic Publication: 2025 Jul 01.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Chainani+Y%22">Chainani Y</searchLink>; Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL, USA.; Center for Synthetic Biology, Evanston, IL, USA.; Joint BioEnergy Institute, Emeryville, CA, USA.; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Diaz+J%22">Diaz J</searchLink>; Joint BioEnergy Institute, Emeryville, CA, USA.; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Guilarte-Silva+M%22">Guilarte-Silva M</searchLink>; Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL, USA.; Center for Synthetic Biology, Evanston, IL, USA.<br /><searchLink fieldCode="AU" term="%22Blay+V%22">Blay V</searchLink>; Joint BioEnergy Institute, Emeryville, CA, USA.; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+Q%22">Zhang Q</searchLink>; Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL, USA.<br /><searchLink fieldCode="AU" term="%22Sprague+W%22">Sprague W</searchLink>; Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL, USA.<br /><searchLink fieldCode="AU" term="%22Tyo+KEJ%22">Tyo KEJ</searchLink>; Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL, USA.; Center for Synthetic Biology, Evanston, IL, USA.<br /><searchLink fieldCode="AU" term="%22Broadbelt+LJ%22">Broadbelt LJ</searchLink>; Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL, USA.; Center for Synthetic Biology, Evanston, IL, USA.; Joint BioEnergy Institute, Emeryville, CA, USA.; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Mukhopadhyay+A%22">Mukhopadhyay A</searchLink>; Joint BioEnergy Institute, Emeryville, CA, USA.; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Keasling+JD%22">Keasling JD</searchLink>; Joint BioEnergy Institute, Emeryville, CA, USA.; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.; QB3, University of California, Berkeley, CA, USA.; Department of Chemical and Biomolecular Engineering, University of California, Berkeley, CA, USA.; Department of Bioengineering, University of California, Berkeley, CA, USA.; Center for Biosustainability, Danish Technical University, Lynby, Denmark.<br /><searchLink fieldCode="AU" term="%22Martin+HG%22">Martin HG</searchLink>; Joint BioEnergy Institute, Emeryville, CA, USA.; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.; BCAM, Basque Center for Applied Mathematics, Bilbao, Spain.; DOE Agile BioFoundry, Emeryville, CA, USA.<br /><searchLink fieldCode="AU" term="%22Backman+TWH%22">Backman TWH</searchLink>; Joint BioEnergy Institute, Emeryville, CA, USA. tbackman@lbl.gov.; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA. tbackman@lbl.gov.
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              Text: 2025 Jul 01
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