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Exploitable mechanisms of antibody and CAR mediated macrophage cytotoxicity.

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Title: Exploitable mechanisms of antibody and CAR mediated macrophage cytotoxicity.
Authors: Liu T; University of California, San Francisco, Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, 94158, USA.; Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA, 94158, USA., Zhang M; University of California, San Francisco, Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, 94158, USA.; Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA, 94158, USA., Farsh T; University of California, San Francisco, Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, 94158, USA.; Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA, 94158, USA., Li H; University of California, San Francisco, Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, 94158, USA.; Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA, 94158, USA., Kishishita A; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA., Barpanda A; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, 94158, USA., Leung SG; University of California, San Francisco, Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, 94158, USA.; Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA, 94158, USA., Zhu J; University of California, San Francisco, Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, 94158, USA.; Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA, 94158, USA., Jung H; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, 94158, USA.; Department of Medicine, University of California, San Francisco, San Francisco, CA, 94143, USA., Hua JT; University of California, San Francisco, Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, 94158, USA.; Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA, 94158, USA., Zhu X; University of California, San Francisco, Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, 94158, USA.; Department of Medicine, University of California, San Francisco, San Francisco, CA, 94143, USA., Kim AB; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, 63108, USA.; Bursky Center for Human Immunology and Immunotherapy, Washington University School of Medicine, St. Louis, MO, 63110, USA., Goo YA; Mass Spectrometry Technology Access Center at McDonnell Genome Institute (MTAC@MGI) at Washington University School of Medicine, St. Louis, MO, 63108, USA., Son M; Mass Spectrometry Technology Access Center at McDonnell Genome Institute (MTAC@MGI) at Washington University School of Medicine, St. Louis, MO, 63108, USA., Kim J; Mass Spectrometry Technology Access Center at McDonnell Genome Institute (MTAC@MGI) at Washington University School of Medicine, St. Louis, MO, 63108, USA., Subramanian A; University of California, San Francisco, Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, 94158, USA.; Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA, 94158, USA., Sjöström M; Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA, 94158, USA.; Department of Clinical Sciences, Division of Oncology, Lund University, Lund, Sweden.; Division of Haematology, Oncology and Radiation Physics, Skåne University Hospital, Lund, Sweden., Fuh KC; University of California, San Francisco, Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, 94158, USA.; Division of gynecologic oncology, University of California, San Francisco, CA, 94158, USA., Chapman JS; University of California, San Francisco, Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, 94158, USA.; Division of gynecologic oncology, University of California, San Francisco, CA, 94158, USA., Carnevale J; University of California, San Francisco, Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, 94158, USA.; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, 94158, USA.; Department of Medicine, University of California, San Francisco, San Francisco, CA, 94143, USA.; Parker Institute for Cancer Immunotherapy, University of California, San Francisco, San Francisco, CA, 94129, USA., Gilbert LA; University of California, San Francisco, Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, 94158, USA.; Department of Urology, University of California, San Francisco, CA, 94158, USA.; Arc Institute, Palo Alto, CA, 94304, USA., Lakkaraju A; Pharmaceutical Sciences and Pharmacogenomics, University of California San Francisco, San Francisco, CA, 94143, USA.; Department of Ophthalmology, University of California San Francisco, San Francisco, CA, 94115, USA., Bruno PM; University of California, San Francisco, Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, 94158, USA.; Department of Urology, University of California, San Francisco, CA, 94158, USA., Quigley D; University of California, San Francisco, Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, 94158, USA.; Department of Urology, University of California, San Francisco, CA, 94158, USA.; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, 94158, USA., Wiita AP; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, 94158, USA.; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, 94143, USA.; Chan Zuckerberg Biohub San Francisco, San Francisco, CA, 94158, USA., Feng FY; University of California, San Francisco, Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, 94158, USA.; Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA, 94158, USA.; Department of Urology, University of California, San Francisco, CA, 94158, USA., DeSelm CJ; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, 63108, USA. deselmc@wustl.edu.; Bursky Center for Human Immunology and Immunotherapy, Washington University School of Medicine, St. Louis, MO, 63110, USA. deselmc@wustl.edu.
Source: Nature communications [Nat Commun] 2025 Jul 01; Vol. 16 (1), pp. 5616. Date of Electronic Publication: 2025 Jul 01.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Liu+T%22">Liu T</searchLink>; University of California, San Francisco, Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, 94158, USA.; Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA, 94158, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+M%22">Zhang M</searchLink>; University of California, San Francisco, Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, 94158, USA.; Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA, 94158, USA.<br /><searchLink fieldCode="AU" term="%22Farsh+T%22">Farsh T</searchLink>; University of California, San Francisco, Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, 94158, USA.; Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA, 94158, USA.<br /><searchLink fieldCode="AU" term="%22Li+H%22">Li H</searchLink>; University of California, San Francisco, Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, 94158, USA.; Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA, 94158, USA.<br /><searchLink fieldCode="AU" term="%22Kishishita+A%22">Kishishita A</searchLink>; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Barpanda+A%22">Barpanda A</searchLink>; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, 94158, USA.<br /><searchLink fieldCode="AU" term="%22Leung+SG%22">Leung SG</searchLink>; University of California, San Francisco, Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, 94158, USA.; Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA, 94158, USA.<br /><searchLink fieldCode="AU" term="%22Zhu+J%22">Zhu J</searchLink>; University of California, San Francisco, Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, 94158, USA.; Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA, 94158, USA.<br /><searchLink fieldCode="AU" term="%22Jung+H%22">Jung H</searchLink>; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, 94158, USA.; Department of Medicine, University of California, San Francisco, San Francisco, CA, 94143, USA.<br /><searchLink fieldCode="AU" term="%22Hua+JT%22">Hua JT</searchLink>; University of California, San Francisco, Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, 94158, USA.; Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA, 94158, USA.<br /><searchLink fieldCode="AU" term="%22Zhu+X%22">Zhu X</searchLink>; University of California, San Francisco, Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, 94158, USA.; Department of Medicine, University of California, San Francisco, San Francisco, CA, 94143, USA.<br /><searchLink fieldCode="AU" term="%22Kim+AB%22">Kim AB</searchLink>; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, 63108, USA.; Bursky Center for Human Immunology and Immunotherapy, Washington University School of Medicine, St. Louis, MO, 63110, USA.<br /><searchLink fieldCode="AU" term="%22Goo+YA%22">Goo YA</searchLink>; Mass Spectrometry Technology Access Center at McDonnell Genome Institute (MTAC@MGI) at Washington University School of Medicine, St. Louis, MO, 63108, USA.<br /><searchLink fieldCode="AU" term="%22Son+M%22">Son M</searchLink>; Mass Spectrometry Technology Access Center at McDonnell Genome Institute (MTAC@MGI) at Washington University School of Medicine, St. Louis, MO, 63108, USA.<br /><searchLink fieldCode="AU" term="%22Kim+J%22">Kim J</searchLink>; Mass Spectrometry Technology Access Center at McDonnell Genome Institute (MTAC@MGI) at Washington University School of Medicine, St. Louis, MO, 63108, USA.<br /><searchLink fieldCode="AU" term="%22Subramanian+A%22">Subramanian A</searchLink>; University of California, San Francisco, Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, 94158, USA.; Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA, 94158, USA.<br /><searchLink fieldCode="AU" term="%22Sjöström+M%22">Sjöström M</searchLink>; Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA, 94158, USA.; Department of Clinical Sciences, Division of Oncology, Lund University, Lund, Sweden.; Division of Haematology, Oncology and Radiation Physics, Skåne University Hospital, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Fuh+KC%22">Fuh KC</searchLink>; University of California, San Francisco, Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, 94158, USA.; Division of gynecologic oncology, University of California, San Francisco, CA, 94158, USA.<br /><searchLink fieldCode="AU" term="%22Chapman+JS%22">Chapman JS</searchLink>; University of California, San Francisco, Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, 94158, USA.; Division of gynecologic oncology, University of California, San Francisco, CA, 94158, USA.<br /><searchLink fieldCode="AU" term="%22Carnevale+J%22">Carnevale J</searchLink>; University of California, San Francisco, Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, 94158, USA.; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, 94158, USA.; Department of Medicine, University of California, San Francisco, San Francisco, CA, 94143, USA.; Parker Institute for Cancer Immunotherapy, University of California, San Francisco, San Francisco, CA, 94129, USA.<br /><searchLink fieldCode="AU" term="%22Gilbert+LA%22">Gilbert LA</searchLink>; University of California, San Francisco, Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, 94158, USA.; Department of Urology, University of California, San Francisco, CA, 94158, USA.; Arc Institute, Palo Alto, CA, 94304, USA.<br /><searchLink fieldCode="AU" term="%22Lakkaraju+A%22">Lakkaraju A</searchLink>; Pharmaceutical Sciences and Pharmacogenomics, University of California San Francisco, San Francisco, CA, 94143, USA.; Department of Ophthalmology, University of California San Francisco, San Francisco, CA, 94115, USA.<br /><searchLink fieldCode="AU" term="%22Bruno+PM%22">Bruno PM</searchLink>; University of California, San Francisco, Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, 94158, USA.; Department of Urology, University of California, San Francisco, CA, 94158, USA.<br /><searchLink fieldCode="AU" term="%22Quigley+D%22">Quigley D</searchLink>; University of California, San Francisco, Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, 94158, USA.; Department of Urology, University of California, San Francisco, CA, 94158, USA.; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, 94158, USA.<br /><searchLink fieldCode="AU" term="%22Wiita+AP%22">Wiita AP</searchLink>; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, 94158, USA.; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, 94143, USA.; Chan Zuckerberg Biohub San Francisco, San Francisco, CA, 94158, USA.<br /><searchLink fieldCode="AU" term="%22Feng+FY%22">Feng FY</searchLink>; University of California, San Francisco, Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, 94158, USA.; Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA, 94158, USA.; Department of Urology, University of California, San Francisco, CA, 94158, USA.<br /><searchLink fieldCode="AU" term="%22DeSelm+CJ%22">DeSelm CJ</searchLink>; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, 63108, USA. deselmc@wustl.edu.; Bursky Center for Human Immunology and Immunotherapy, Washington University School of Medicine, St. Louis, MO, 63110, USA. deselmc@wustl.edu.
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