Engineering the bone metastatic prostate cancer niche through a microphysiological system to report patient-specific treatment response.

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Title: Engineering the bone metastatic prostate cancer niche through a microphysiological system to report patient-specific treatment response.
Authors: Sánchez-de-Diego C; Carbone Cancer Center, University of Wisconsin, Madison, WI, USA.; Department of Pathology & Laboratory Medicine, University of Wisconsin, Madison, WI, USA.; Department of Biomedical Engineering, University of Wisconsin, Madison, WI, USA., Yada RC; Carbone Cancer Center, University of Wisconsin, Madison, WI, USA.; Department of Pathology & Laboratory Medicine, University of Wisconsin, Madison, WI, USA.; Department of Biomedical Engineering, University of Wisconsin, Madison, WI, USA.; Department of Cellular and Molecular Biology, University of Wisconsin, Madison, WI, USA., Sethakorn N; Department of Medicine, Loyola University Chicago, Chicago, IL, USA.; Department of Cancer Biology, Loyola University Chicago, Chicago, IL, USA., Geiger PG; Department of Pathology & Laboratory Medicine, University of Wisconsin, Madison, WI, USA., Ding AB; Carbone Cancer Center, University of Wisconsin, Madison, WI, USA., Heninger E; Carbone Cancer Center, University of Wisconsin, Madison, WI, USA., Ahmed F; Department of Pathology & Laboratory Medicine, University of Wisconsin, Madison, WI, USA.; Department of Biomedical Engineering, University of Wisconsin, Madison, WI, USA., Virumbrales-Muñoz M; Carbone Cancer Center, University of Wisconsin, Madison, WI, USA.; Department of Obstetrics and Gynecology, University of Wisconsin, Madison, WI, USA., Lupsa N; Carbone Cancer Center, University of Wisconsin, Madison, WI, USA., Bartels E; Department of Pathology & Laboratory Medicine, University of Wisconsin, Madison, WI, USA., Stewart K; Department of Pathology & Laboratory Medicine, University of Wisconsin, Madison, WI, USA.; Department of Biomedical Engineering, University of Wisconsin, Madison, WI, USA., Ponik SM; Carbone Cancer Center, University of Wisconsin, Madison, WI, USA.; Department of Cell and Regenerative Biology, University of Wisconsin, Madison, WI, USA., Sharifi MN; Carbone Cancer Center, University of Wisconsin, Madison, WI, USA.; Department of Medicine, University of Wisconsin, Madison, WI, USA., Lang JM; Carbone Cancer Center, University of Wisconsin, Madison, WI, USA. jmlang@medicine.wisc.edu.; Department of Medicine, University of Wisconsin, Madison, WI, USA. jmlang@medicine.wisc.edu., Beebe DJ; Carbone Cancer Center, University of Wisconsin, Madison, WI, USA. djbeebe@wisc.edu.; Department of Pathology & Laboratory Medicine, University of Wisconsin, Madison, WI, USA. djbeebe@wisc.edu.; Department of Biomedical Engineering, University of Wisconsin, Madison, WI, USA. djbeebe@wisc.edu., Kerr SC; Carbone Cancer Center, University of Wisconsin, Madison, WI, USA. skerr2@wisc.edu.
Source: Communications biology [Commun Biol] 2025 Jul 01; Vol. 8 (1), pp. 961. Date of Electronic Publication: 2025 Jul 01.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2399-3642
DOI:10.1038/s42003-025-08384-2