Elucidating brain transport pathways and cell type-dependent gene silencing of a durable lipid-siRNA conjugate administered into cerebrospinal fluid.
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| Title: | Elucidating brain transport pathways and cell type-dependent gene silencing of a durable lipid-siRNA conjugate administered into cerebrospinal fluid. |
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| Authors: | Sorets AG; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37240, United States., Schwensen KR; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN 37240, United States., Francini N; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37240, United States., Kjar A; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37240, United States., Abdulrahman AM; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37240, United States., Shostak A; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37240, United States., Katdare KA; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN 37240, United States., Schoch KM; Department of Neurology, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, United States., Cowell RP; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN 37240, United States., Park JC; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN 37240, United States., Ligocki AP; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN 37240, United States., Ford WT; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN 37240, United States., Ventura-Antunes L; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37240, United States., Hoogenboezem EN; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37240, United States., Prusky A; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37240, United States., Castleberry M; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37240, United States., Michell DL; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37240, United States., Fritsch E; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN 37240, United States., Lyons SM; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN 37240, United States., Miller TM; Department of Neurology, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, United States., Vickers KC; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37240, United States., Schrag MS; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37240, United States.; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN 37240, United States., Duvall CL; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37240, United States.; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN 37240, United States., Lippmann ES; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37240, United States.; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN 37240, United States.; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37240, United States.; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN 37240, United States.; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN 37240, United States. |
| Source: | Nucleic acids research [Nucleic Acids Res] 2025 Jun 20; Vol. 53 (12). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1362-4962 |
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| DOI: | 10.1093/nar/gkaf600 |