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Elucidating brain transport pathways and cell type-dependent gene silencing of a durable lipid-siRNA conjugate administered into cerebrospinal fluid.

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Title: Elucidating brain transport pathways and cell type-dependent gene silencing of a durable lipid-siRNA conjugate administered into cerebrospinal fluid.
Authors: Sorets AG; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37240, United States., Schwensen KR; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN 37240, United States., Francini N; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37240, United States., Kjar A; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37240, United States., Abdulrahman AM; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37240, United States., Shostak A; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37240, United States., Katdare KA; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN 37240, United States., Schoch KM; Department of Neurology, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, United States., Cowell RP; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN 37240, United States., Park JC; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN 37240, United States., Ligocki AP; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN 37240, United States., Ford WT; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN 37240, United States., Ventura-Antunes L; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37240, United States., Hoogenboezem EN; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37240, United States., Prusky A; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37240, United States., Castleberry M; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37240, United States., Michell DL; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37240, United States., Fritsch E; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN 37240, United States., Lyons SM; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN 37240, United States., Miller TM; Department of Neurology, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, United States., Vickers KC; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37240, United States., Schrag MS; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37240, United States.; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN 37240, United States., Duvall CL; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37240, United States.; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN 37240, United States., Lippmann ES; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37240, United States.; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN 37240, United States.; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37240, United States.; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN 37240, United States.; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN 37240, United States.
Source: Nucleic acids research [Nucleic Acids Res] 2025 Jun 20; Vol. 53 (12).
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Elucidating brain transport pathways and cell type-dependent gene silencing of a durable lipid-siRNA conjugate administered into cerebrospinal fluid.
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Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN 37240, United States.<br /><searchLink fieldCode="AU" term="%22Schoch+KM%22">Schoch KM</searchLink>; Department of Neurology, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, United States.<br /><searchLink fieldCode="AU" term="%22Cowell+RP%22">Cowell RP</searchLink>; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN 37240, United States.<br /><searchLink fieldCode="AU" term="%22Park+JC%22">Park JC</searchLink>; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN 37240, United States.<br /><searchLink fieldCode="AU" term="%22Ligocki+AP%22">Ligocki AP</searchLink>; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN 37240, United States.<br /><searchLink fieldCode="AU" term="%22Ford+WT%22">Ford WT</searchLink>; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN 37240, United States.<br /><searchLink fieldCode="AU" term="%22Ventura-Antunes+L%22">Ventura-Antunes L</searchLink>; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37240, United States.<br /><searchLink fieldCode="AU" term="%22Hoogenboezem+EN%22">Hoogenboezem EN</searchLink>; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37240, United States.<br /><searchLink fieldCode="AU" term="%22Prusky+A%22">Prusky A</searchLink>; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37240, United States.<br /><searchLink fieldCode="AU" term="%22Castleberry+M%22">Castleberry M</searchLink>; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37240, United States.<br /><searchLink fieldCode="AU" term="%22Michell+DL%22">Michell DL</searchLink>; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37240, United States.<br /><searchLink fieldCode="AU" term="%22Fritsch+E%22">Fritsch E</searchLink>; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN 37240, United States.<br /><searchLink fieldCode="AU" term="%22Lyons+SM%22">Lyons SM</searchLink>; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN 37240, United States.<br /><searchLink fieldCode="AU" term="%22Miller+TM%22">Miller TM</searchLink>; Department of Neurology, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, United States.<br /><searchLink fieldCode="AU" term="%22Vickers+KC%22">Vickers KC</searchLink>; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37240, United States.<br /><searchLink fieldCode="AU" term="%22Schrag+MS%22">Schrag MS</searchLink>; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37240, United States.; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN 37240, United States.<br /><searchLink fieldCode="AU" term="%22Duvall+CL%22">Duvall CL</searchLink>; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37240, United States.; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN 37240, United States.<br /><searchLink fieldCode="AU" term="%22Lippmann+ES%22">Lippmann ES</searchLink>; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37240, United States.; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN 37240, United States.; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37240, United States.; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN 37240, United States.; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN 37240, United States.
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        Value: 10.1093/nar/gkaf600
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