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Colorectal cancer-infiltrating NK cell landscape analysis unravels tissue-resident PD-1+ NK cells in microsatellite instability tumors.

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Title: Colorectal cancer-infiltrating NK cell landscape analysis unravels tissue-resident PD-1+ NK cells in microsatellite instability tumors.
Authors: Obino V; Department of Experimental Medicine (DIMES), University of Genoa, Genoa, Italy., Giordano C; Department of Experimental Medicine (DIMES), University of Genoa, Genoa, Italy., Carlomagno S; Department of Medicine (DMED), University of Udine, Udine, Italy., Setti C; Department of Experimental Medicine (DIMES), University of Genoa, Genoa, Italy., Greppi M; Department of Experimental Medicine (DIMES), University of Genoa, Genoa, Italy., Bozzo M; Department of Earth, Environmental and Life Sciences (DISTAV), University of Genoa, Genoa, Italy., Pesce S; Department of Experimental Medicine (DIMES), University of Genoa, Genoa, Italy.; Direzione Scientifica, IRCCS Ospedale Policlinico San Martino, Genoa, Italy., Ferretti E; Department of Experimental Medicine (DIMES), University of Genoa, Genoa, Italy.; U.O. Medicina di Laboratorio, IRCCS Ospedale Policlinico San Martino, Genoa, Italy., Candiani S; Department of Earth, Environmental and Life Sciences (DISTAV), University of Genoa, Genoa, Italy.; Direzione Scientifica, IRCCS Ospedale Policlinico San Martino, Genoa, Italy., Muccio L; Department of Experimental Medicine (DIMES), University of Genoa, Genoa, Italy., Ciferri E; Department of Abdominal Surgery - General and Hepatobiliopancreatic Surgery Unit, E.O. Ospedali Galliera, Genoa, Italy., Buttiron Webber T; Division of Medical Oncology, E.O. Ospedali Galliera, Genoa, Italy., Solari A; Department of Experimental Medicine (DIMES), University of Genoa, Genoa, Italy., Ortolani F; Department of Medicine (DMED), University of Udine, Udine, Italy., Paleari L; ALiSa, Liguria Health Authority, Genoa, Italy., Clavarezza M; Division of Medical Oncology, E.O. Ospedali Galliera, Genoa, Italy., Barberis A; Department of Abdominal Surgery - General and Hepatobiliopancreatic Surgery Unit, E.O. Ospedali Galliera, Genoa, Italy., Filauro M; Department of Abdominal Surgery - General and Hepatobiliopancreatic Surgery Unit, E.O. Ospedali Galliera, Genoa, Italy., Provinciali N; Department of Experimental Medicine (DIMES), University of Genoa, Genoa, Italy.; Division of Medical Oncology, E.O. Ospedali Galliera, Genoa, Italy., Rutigliani M; Department of Laboratory and Service - Histological and Anatomical Pathology Unit, E.O. Ospedali Galliera, Genoa, Italy., Marcenaro E; Department of Experimental Medicine (DIMES), University of Genoa, Genoa, Italy.; Direzione Scientifica, IRCCS Ospedale Policlinico San Martino, Genoa, Italy., DeCensi A; Division of Medical Oncology, E.O. Ospedali Galliera, Genoa, Italy.; Wolfson Institute of Population Health, Queen Mary University of London, London, United Kingdom., Della Chiesa M; Department of Experimental Medicine (DIMES), University of Genoa, Genoa, Italy.; Direzione Scientifica, IRCCS Ospedale Policlinico San Martino, Genoa, Italy., Sivori S; Department of Experimental Medicine (DIMES), University of Genoa, Genoa, Italy.; Direzione Scientifica, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Source: Frontiers in immunology [Front Immunol] 2025 Jun 18; Vol. 16, pp. 1578444. Date of Electronic Publication: 2025 Jun 18 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
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  Data: Colorectal cancer-infiltrating NK cell landscape analysis unravels tissue-resident PD-1<superscript>+</superscript> NK cells in microsatellite instability tumors.
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  Data: <searchLink fieldCode="AU" term="%22Obino+V%22">Obino V</searchLink>; Department of Experimental Medicine (DIMES), University of Genoa, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Giordano+C%22">Giordano C</searchLink>; Department of Experimental Medicine (DIMES), University of Genoa, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Carlomagno+S%22">Carlomagno S</searchLink>; Department of Medicine (DMED), University of Udine, Udine, Italy.<br /><searchLink fieldCode="AU" term="%22Setti+C%22">Setti C</searchLink>; Department of Experimental Medicine (DIMES), University of Genoa, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Greppi+M%22">Greppi M</searchLink>; Department of Experimental Medicine (DIMES), University of Genoa, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Bozzo+M%22">Bozzo M</searchLink>; Department of Earth, Environmental and Life Sciences (DISTAV), University of Genoa, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Pesce+S%22">Pesce S</searchLink>; Department of Experimental Medicine (DIMES), University of Genoa, Genoa, Italy.; Direzione Scientifica, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Ferretti+E%22">Ferretti E</searchLink>; Department of Experimental Medicine (DIMES), University of Genoa, Genoa, Italy.; U.O. Medicina di Laboratorio, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Candiani+S%22">Candiani S</searchLink>; Department of Earth, Environmental and Life Sciences (DISTAV), University of Genoa, Genoa, Italy.; Direzione Scientifica, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Muccio+L%22">Muccio L</searchLink>; Department of Experimental Medicine (DIMES), University of Genoa, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Ciferri+E%22">Ciferri E</searchLink>; Department of Abdominal Surgery - General and Hepatobiliopancreatic Surgery Unit, E.O. Ospedali Galliera, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Buttiron+Webber+T%22">Buttiron Webber T</searchLink>; Division of Medical Oncology, E.O. Ospedali Galliera, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Solari+A%22">Solari A</searchLink>; Department of Experimental Medicine (DIMES), University of Genoa, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Ortolani+F%22">Ortolani F</searchLink>; Department of Medicine (DMED), University of Udine, Udine, Italy.<br /><searchLink fieldCode="AU" term="%22Paleari+L%22">Paleari L</searchLink>; ALiSa, Liguria Health Authority, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Clavarezza+M%22">Clavarezza M</searchLink>; Division of Medical Oncology, E.O. Ospedali Galliera, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Barberis+A%22">Barberis A</searchLink>; Department of Abdominal Surgery - General and Hepatobiliopancreatic Surgery Unit, E.O. Ospedali Galliera, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Filauro+M%22">Filauro M</searchLink>; Department of Abdominal Surgery - General and Hepatobiliopancreatic Surgery Unit, E.O. Ospedali Galliera, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Provinciali+N%22">Provinciali N</searchLink>; Department of Experimental Medicine (DIMES), University of Genoa, Genoa, Italy.; Division of Medical Oncology, E.O. Ospedali Galliera, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Rutigliani+M%22">Rutigliani M</searchLink>; Department of Laboratory and Service - Histological and Anatomical Pathology Unit, E.O. Ospedali Galliera, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Marcenaro+E%22">Marcenaro E</searchLink>; Department of Experimental Medicine (DIMES), University of Genoa, Genoa, Italy.; Direzione Scientifica, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22DeCensi+A%22">DeCensi A</searchLink>; Division of Medical Oncology, E.O. Ospedali Galliera, Genoa, Italy.; Wolfson Institute of Population Health, Queen Mary University of London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Della+Chiesa+M%22">Della Chiesa M</searchLink>; Department of Experimental Medicine (DIMES), University of Genoa, Genoa, Italy.; Direzione Scientifica, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Sivori+S%22">Sivori S</searchLink>; Department of Experimental Medicine (DIMES), University of Genoa, Genoa, Italy.; Direzione Scientifica, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
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