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PPARδ Orchestrates a Prometastatic Metabolic Response to Microenvironmental Cues in Pancreatic Cancer.

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Title: PPARδ Orchestrates a Prometastatic Metabolic Response to Microenvironmental Cues in Pancreatic Cancer.
Authors: Parejo-Alonso B; Aragon Health Research Institute (IIS Aragón), Zaragoza, Spain., Barneda D; Barts Cancer Institute, Queen Mary University of London, London, United Kingdom., Trabulo SMD; Barts Cancer Institute, Queen Mary University of London, London, United Kingdom., Courtois S; Aragon Health Research Institute (IIS Aragón), Zaragoza, Spain., Compte-Sancerni S; Barts Cancer Institute, Queen Mary University of London, London, United Kingdom., Zurkovic J; LIMES Life and Medical Sciences Institute, University of Bonn, Bonn, Germany., Ruiz-Cañas L; Department of Biochemistry, Autónoma University of Madrid (UAM), School of Medicine, Instituto de Investigaciones Biomédicas (IIBm) Sols-Morreale (CSIC-UAM), Madrid, Spain.; Cancer, Area 3, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain., Zheng Q; Center for Single-Cell Omics and State Key Laboratory of Systems Medicine for Cancer, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Tang J; Center for Single-Cell Omics and State Key Laboratory of Systems Medicine for Cancer, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Gaida MM; Institute of Pathology, University Medical Center Mainz, JGU-Mainz, Mainz, Germany.; TRON Translational Oncology at the University Medical Center, JGU-Mainz, Mainz, Germany.; Research Center for Immunotherapy, University Medical Center Mainz, JGU-Mainz, Mainz, Germany., Schmitz U; Computational Biomedicine Lab, College of Science and Engineering, James Cook University, Townsville, Australia., Irun P; Aragon Health Research Institute (IIS Aragón), Zaragoza, Spain.; Liver and Digestive Diseases Networking Biomedical Research Centre (CIBEREHD), Carlos III Health Institute (ISCIII), Zaragoza, Spain., Penin-Peyta L; Barts Cancer Institute, Queen Mary University of London, London, United Kingdom., Crusz SM; Barts Cancer Institute, Queen Mary University of London, London, United Kingdom., Jagušt P; Barts Cancer Institute, Queen Mary University of London, London, United Kingdom., Espiau-Romera P; Aragon Health Research Institute (IIS Aragón), Zaragoza, Spain., Royo-García A; Aragon Health Research Institute (IIS Aragón), Zaragoza, Spain., Gordo-Ortiz A; Aragon Health Research Institute (IIS Aragón), Zaragoza, Spain., Yuneva M; Oncogenes and Tumour Metabolism Laboratory, Francis Crick Institute, London, United Kingdom., Lin ML; Barts Cancer Institute, Queen Mary University of London, London, United Kingdom., Huang S; Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy.; Pancreatic Cancer Heterogeneity, Candiolo Cancer Institute - FPO - IRCCS, Torino, Italy., Yang MH; Barts Cancer Institute, Queen Mary University of London, London, United Kingdom.; Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan., Lanas A; Aragon Health Research Institute (IIS Aragón), Zaragoza, Spain.; Liver and Digestive Diseases Networking Biomedical Research Centre (CIBEREHD), Carlos III Health Institute (ISCIII), Zaragoza, Spain.; Department of Gastroenterology, Hospital Universitario Lozano Blesa, Universidad de Zaragoza, Zaragoza, Spain., Sainz B Jr; Department of Biochemistry, Autónoma University of Madrid (UAM), School of Medicine, Instituto de Investigaciones Biomédicas (IIBm) Sols-Morreale (CSIC-UAM), Madrid, Spain.; Cancer, Area 3, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain., Thiele C; LIMES Life and Medical Sciences Institute, University of Bonn, Bonn, Germany., Heeschen C; Pancreatic Cancer Heterogeneity, Candiolo Cancer Institute - FPO - IRCCS, Torino, Italy., Sancho P; Aragon Health Research Institute (IIS Aragón), Zaragoza, Spain.; Barts Cancer Institute, Queen Mary University of London, London, United Kingdom.
Source: Cancer research [Cancer Res] 2025 Sep 02; Vol. 85 (17), pp. 3275-3291.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: PPARδ Orchestrates a Prometastatic Metabolic Response to Microenvironmental Cues in Pancreatic Cancer.
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  Data: <searchLink fieldCode="AU" term="%22Parejo-Alonso+B%22">Parejo-Alonso B</searchLink>; Aragon Health Research Institute (IIS Aragón), Zaragoza, Spain.<br /><searchLink fieldCode="AU" term="%22Barneda+D%22">Barneda D</searchLink>; Barts Cancer Institute, Queen Mary University of London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Trabulo+SMD%22">Trabulo SMD</searchLink>; Barts Cancer Institute, Queen Mary University of London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Courtois+S%22">Courtois S</searchLink>; Aragon Health Research Institute (IIS Aragón), Zaragoza, Spain.<br /><searchLink fieldCode="AU" term="%22Compte-Sancerni+S%22">Compte-Sancerni S</searchLink>; Barts Cancer Institute, Queen Mary University of London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Zurkovic+J%22">Zurkovic J</searchLink>; LIMES Life and Medical Sciences Institute, University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Ruiz-Cañas+L%22">Ruiz-Cañas L</searchLink>; Department of Biochemistry, Autónoma University of Madrid (UAM), School of Medicine, Instituto de Investigaciones Biomédicas (IIBm) Sols-Morreale (CSIC-UAM), Madrid, Spain.; Cancer, Area 3, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Zheng+Q%22">Zheng Q</searchLink>; Center for Single-Cell Omics and State Key Laboratory of Systems Medicine for Cancer, Shanghai Jiao Tong University School of Medicine, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Tang+J%22">Tang J</searchLink>; Center for Single-Cell Omics and State Key Laboratory of Systems Medicine for Cancer, Shanghai Jiao Tong University School of Medicine, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Gaida+MM%22">Gaida MM</searchLink>; Institute of Pathology, University Medical Center Mainz, JGU-Mainz, Mainz, Germany.; TRON Translational Oncology at the University Medical Center, JGU-Mainz, Mainz, Germany.; Research Center for Immunotherapy, University Medical Center Mainz, JGU-Mainz, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Schmitz+U%22">Schmitz U</searchLink>; Computational Biomedicine Lab, College of Science and Engineering, James Cook University, Townsville, Australia.<br /><searchLink fieldCode="AU" term="%22Irun+P%22">Irun P</searchLink>; Aragon Health Research Institute (IIS Aragón), Zaragoza, Spain.; Liver and Digestive Diseases Networking Biomedical Research Centre (CIBEREHD), Carlos III Health Institute (ISCIII), Zaragoza, Spain.<br /><searchLink fieldCode="AU" term="%22Penin-Peyta+L%22">Penin-Peyta L</searchLink>; Barts Cancer Institute, Queen Mary University of London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Crusz+SM%22">Crusz SM</searchLink>; Barts Cancer Institute, Queen Mary University of London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Jagušt+P%22">Jagušt P</searchLink>; Barts Cancer Institute, Queen Mary University of London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Espiau-Romera+P%22">Espiau-Romera P</searchLink>; Aragon Health Research Institute (IIS Aragón), Zaragoza, Spain.<br /><searchLink fieldCode="AU" term="%22Royo-García+A%22">Royo-García A</searchLink>; Aragon Health Research Institute (IIS Aragón), Zaragoza, Spain.<br /><searchLink fieldCode="AU" term="%22Gordo-Ortiz+A%22">Gordo-Ortiz A</searchLink>; Aragon Health Research Institute (IIS Aragón), Zaragoza, Spain.<br /><searchLink fieldCode="AU" term="%22Yuneva+M%22">Yuneva M</searchLink>; Oncogenes and Tumour Metabolism Laboratory, Francis Crick Institute, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Lin+ML%22">Lin ML</searchLink>; Barts Cancer Institute, Queen Mary University of London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Huang+S%22">Huang S</searchLink>; Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy.; Pancreatic Cancer Heterogeneity, Candiolo Cancer Institute - FPO - IRCCS, Torino, Italy.<br /><searchLink fieldCode="AU" term="%22Yang+MH%22">Yang MH</searchLink>; Barts Cancer Institute, Queen Mary University of London, London, United Kingdom.; Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lanas+A%22">Lanas A</searchLink>; Aragon Health Research Institute (IIS Aragón), Zaragoza, Spain.; Liver and Digestive Diseases Networking Biomedical Research Centre (CIBEREHD), Carlos III Health Institute (ISCIII), Zaragoza, Spain.; Department of Gastroenterology, Hospital Universitario Lozano Blesa, Universidad de Zaragoza, Zaragoza, Spain.<br /><searchLink fieldCode="AU" term="%22Sainz+B+Jr%22">Sainz B Jr</searchLink>; Department of Biochemistry, Autónoma University of Madrid (UAM), School of Medicine, Instituto de Investigaciones Biomédicas (IIBm) Sols-Morreale (CSIC-UAM), Madrid, Spain.; Cancer, Area 3, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Thiele+C%22">Thiele C</searchLink>; LIMES Life and Medical Sciences Institute, University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Heeschen+C%22">Heeschen C</searchLink>; Pancreatic Cancer Heterogeneity, Candiolo Cancer Institute - FPO - IRCCS, Torino, Italy.<br /><searchLink fieldCode="AU" term="%22Sancho+P%22">Sancho P</searchLink>; Aragon Health Research Institute (IIS Aragón), Zaragoza, Spain.; Barts Cancer Institute, Queen Mary University of London, London, United Kingdom.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+Cancer+Research%22">American Association for Cancer Research </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>2984705R <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1538-7445 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200085472%22">00085472 </searchLink><i>NLM ISO Abbreviation: </i>Cancer Res <i>Subsets: </i>MEDLINE
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