Computer-aided tumor cell fraction (TCF) estimation by medical students, residents, and pathologists improves inter-observer agreement while highlighting the risk of automation bias.

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Title: Computer-aided tumor cell fraction (TCF) estimation by medical students, residents, and pathologists improves inter-observer agreement while highlighting the risk of automation bias.
Authors: Frei AL; Institute of Tissue Medicine and Pathology (ITMP), University of Bern, Murtenstrasse 31, 3008, Bern, Switzerland., Khan A; Institute of Tissue Medicine and Pathology (ITMP), University of Bern, Murtenstrasse 31, 3008, Bern, Switzerland., Oberson R; Institute of Tissue Medicine and Pathology (ITMP), University of Bern, Murtenstrasse 31, 3008, Bern, Switzerland., Reinhard S; Institute of Tissue Medicine and Pathology (ITMP), University of Bern, Murtenstrasse 31, 3008, Bern, Switzerland., Banz Y; Institute of Tissue Medicine and Pathology (ITMP), University of Bern, Murtenstrasse 31, 3008, Bern, Switzerland., Meeuwsen F; Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands., Janowczyk A; Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA, USA.; Department of Oncology, Division of Precision Oncology, University Hospital of Geneva, Geneva, Switzerland.; Department of Diagnostics, Division of Clinical Pathology, University Hospital of Geneva, Geneva, Switzerland., Grobholz R; Medical Faculty, University of Zurich, Zurich, Switzerland.; Institute of Pathology Cantonal Hospital Aarau, Aarau, Switzerland., Dawson HE; Institute of Tissue Medicine and Pathology (ITMP), University of Bern, Murtenstrasse 31, 3008, Bern, Switzerland., Lugli A; Institute of Tissue Medicine and Pathology (ITMP), University of Bern, Murtenstrasse 31, 3008, Bern, Switzerland., Ilié M; Laboratory of Clinical and Experimental Pathology, Hospital-Integrated Biobank (BB-0033-00025), IHU RespirERA, University Hospital Centre Nice, University Côte d'Azur, Nice, France., van der Laak J; Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands., Zlobec I; Institute of Tissue Medicine and Pathology (ITMP), University of Bern, Murtenstrasse 31, 3008, Bern, Switzerland. Inti.zlobec@unibe.ch.
Source: Virchows Archiv : an international journal of pathology [Virchows Arch] 2025 Jul 04. Date of Electronic Publication: 2025 Jul 04.
Publication Type: Journal Article
Journal Info: Publisher: Springer International Country of Publication: Germany NLM ID: 9423843 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-2307 (Electronic) Linking ISSN: 09456317 NLM ISO Abbreviation: Virchows Arch Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1432-2307
DOI:10.1007/s00428-025-04163-w