Computer-aided tumor cell fraction (TCF) estimation by medical students, residents, and pathologists improves inter-observer agreement while highlighting the risk of automation bias.

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Title: Computer-aided tumor cell fraction (TCF) estimation by medical students, residents, and pathologists improves inter-observer agreement while highlighting the risk of automation bias.
Authors: Frei AL; Institute of Tissue Medicine and Pathology (ITMP), University of Bern, Murtenstrasse 31, 3008, Bern, Switzerland., Khan A; Institute of Tissue Medicine and Pathology (ITMP), University of Bern, Murtenstrasse 31, 3008, Bern, Switzerland., Oberson R; Institute of Tissue Medicine and Pathology (ITMP), University of Bern, Murtenstrasse 31, 3008, Bern, Switzerland., Reinhard S; Institute of Tissue Medicine and Pathology (ITMP), University of Bern, Murtenstrasse 31, 3008, Bern, Switzerland., Banz Y; Institute of Tissue Medicine and Pathology (ITMP), University of Bern, Murtenstrasse 31, 3008, Bern, Switzerland., Meeuwsen F; Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands., Janowczyk A; Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA, USA.; Department of Oncology, Division of Precision Oncology, University Hospital of Geneva, Geneva, Switzerland.; Department of Diagnostics, Division of Clinical Pathology, University Hospital of Geneva, Geneva, Switzerland., Grobholz R; Medical Faculty, University of Zurich, Zurich, Switzerland.; Institute of Pathology Cantonal Hospital Aarau, Aarau, Switzerland., Dawson HE; Institute of Tissue Medicine and Pathology (ITMP), University of Bern, Murtenstrasse 31, 3008, Bern, Switzerland., Lugli A; Institute of Tissue Medicine and Pathology (ITMP), University of Bern, Murtenstrasse 31, 3008, Bern, Switzerland., Ilié M; Laboratory of Clinical and Experimental Pathology, Hospital-Integrated Biobank (BB-0033-00025), IHU RespirERA, University Hospital Centre Nice, University Côte d'Azur, Nice, France., van der Laak J; Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands., Zlobec I; Institute of Tissue Medicine and Pathology (ITMP), University of Bern, Murtenstrasse 31, 3008, Bern, Switzerland. Inti.zlobec@unibe.ch.
Source: Virchows Archiv : an international journal of pathology [Virchows Arch] 2025 Jul 04. Date of Electronic Publication: 2025 Jul 04.
Publication Type: Journal Article
Journal Info: Publisher: Springer International Country of Publication: Germany NLM ID: 9423843 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-2307 (Electronic) Linking ISSN: 09456317 NLM ISO Abbreviation: Virchows Arch Subsets: MEDLINE
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  Data: Computer-aided tumor cell fraction (TCF) estimation by medical students, residents, and pathologists improves inter-observer agreement while highlighting the risk of automation bias.
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  Data: <searchLink fieldCode="AU" term="%22Frei+AL%22">Frei AL</searchLink>; Institute of Tissue Medicine and Pathology (ITMP), University of Bern, Murtenstrasse 31, 3008, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Khan+A%22">Khan A</searchLink>; Institute of Tissue Medicine and Pathology (ITMP), University of Bern, Murtenstrasse 31, 3008, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Oberson+R%22">Oberson R</searchLink>; Institute of Tissue Medicine and Pathology (ITMP), University of Bern, Murtenstrasse 31, 3008, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Reinhard+S%22">Reinhard S</searchLink>; Institute of Tissue Medicine and Pathology (ITMP), University of Bern, Murtenstrasse 31, 3008, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Banz+Y%22">Banz Y</searchLink>; Institute of Tissue Medicine and Pathology (ITMP), University of Bern, Murtenstrasse 31, 3008, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Meeuwsen+F%22">Meeuwsen F</searchLink>; Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Janowczyk+A%22">Janowczyk A</searchLink>; Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA, USA.; Department of Oncology, Division of Precision Oncology, University Hospital of Geneva, Geneva, Switzerland.; Department of Diagnostics, Division of Clinical Pathology, University Hospital of Geneva, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Grobholz+R%22">Grobholz R</searchLink>; Medical Faculty, University of Zurich, Zurich, Switzerland.; Institute of Pathology Cantonal Hospital Aarau, Aarau, Switzerland.<br /><searchLink fieldCode="AU" term="%22Dawson+HE%22">Dawson HE</searchLink>; Institute of Tissue Medicine and Pathology (ITMP), University of Bern, Murtenstrasse 31, 3008, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Lugli+A%22">Lugli A</searchLink>; Institute of Tissue Medicine and Pathology (ITMP), University of Bern, Murtenstrasse 31, 3008, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Ilié+M%22">Ilié M</searchLink>; Laboratory of Clinical and Experimental Pathology, Hospital-Integrated Biobank (BB-0033-00025), IHU RespirERA, University Hospital Centre Nice, University Côte d'Azur, Nice, France.<br /><searchLink fieldCode="AU" term="%22van+der+Laak+J%22">van der Laak J</searchLink>; Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Zlobec+I%22">Zlobec I</searchLink>; Institute of Tissue Medicine and Pathology (ITMP), University of Bern, Murtenstrasse 31, 3008, Bern, Switzerland. Inti.zlobec@unibe.ch.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+International%22">Springer International </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>9423843 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1432-2307 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209456317%22">09456317 </searchLink><i>NLM ISO Abbreviation: </i>Virchows Arch <i>Subsets: </i>MEDLINE
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              Text: 2025 Jul 04
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