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Integrated in vivo functional screens and multiomics analyses identify α-2,3-sialylation as essential for melanoma maintenance.

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Title: Integrated in vivo functional screens and multiomics analyses identify α-2,3-sialylation as essential for melanoma maintenance.
Authors: Agrawal P; Department of Pathology, NYU Grossman School of Medicine, New York, NY, USA.; Interdisciplinary Melanoma Cooperative Group, Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA.; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA.; Montefiore Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, NY, USA.; Cancer Dormancy Institute, Albert Einstein College of Medicine, Bronx, NY, USA., Chen S; Department of Chemistry, New York University, New York, NY, USA., de Pablos A; Department of Pathology, NYU Grossman School of Medicine, New York, NY, USA.; Interdisciplinary Melanoma Cooperative Group, Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA.; Centro Nacional de Investigaciones Oncologicas, Madrid, Spain., Vadlamudi Y; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA.; Montefiore Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, NY, USA., Vand-Rajabpour F; Department of Pathology, NYU Grossman School of Medicine, New York, NY, USA.; Interdisciplinary Melanoma Cooperative Group, Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA., Jame-Chenarboo F; Department of Chemistry, University of Alberta, Edmonton, Canada., Kar S; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA., Yanke AF; Department of Pathology, NYU Grossman School of Medicine, New York, NY, USA.; Interdisciplinary Melanoma Cooperative Group, Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA., Berico P; Department of Pathology, NYU Grossman School of Medicine, New York, NY, USA.; Interdisciplinary Melanoma Cooperative Group, Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA., de Vega EMS; Department of Dermatology, NYU Grossman School of Medicine, New York, NY, USA., Darvishian F; Department of Pathology, NYU Grossman School of Medicine, New York, NY, USA., Osman I; Interdisciplinary Melanoma Cooperative Group, Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA.; Department of Dermatology, NYU Grossman School of Medicine, New York, NY, USA., Lujambio A; Icahn School of Medicine at Mount Sinai, New York, NY, USA., Mahal LK; Department of Chemistry, New York University, New York, NY, USA.; Department of Chemistry, University of Alberta, Edmonton, Canada., Hernando E; Department of Pathology, NYU Grossman School of Medicine, New York, NY, USA.; Interdisciplinary Melanoma Cooperative Group, Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA.
Source: Science advances [Sci Adv] 2025 Jul 04; Vol. 11 (27), pp. eadg3481. Date of Electronic Publication: 2025 Jul 04.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
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  Data: Integrated in vivo functional screens and multiomics analyses identify α-2,3-sialylation as essential for melanoma maintenance.
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  Data: <searchLink fieldCode="AU" term="%22Agrawal+P%22">Agrawal P</searchLink>; Department of Pathology, NYU Grossman School of Medicine, New York, NY, USA.; Interdisciplinary Melanoma Cooperative Group, Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA.; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA.; Montefiore Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, NY, USA.; Cancer Dormancy Institute, Albert Einstein College of Medicine, Bronx, NY, USA.<br /><searchLink fieldCode="AU" term="%22Chen+S%22">Chen S</searchLink>; Department of Chemistry, New York University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22de+Pablos+A%22">de Pablos A</searchLink>; Department of Pathology, NYU Grossman School of Medicine, New York, NY, USA.; Interdisciplinary Melanoma Cooperative Group, Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA.; Centro Nacional de Investigaciones Oncologicas, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Vadlamudi+Y%22">Vadlamudi Y</searchLink>; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA.; Montefiore Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, NY, USA.<br /><searchLink fieldCode="AU" term="%22Vand-Rajabpour+F%22">Vand-Rajabpour F</searchLink>; Department of Pathology, NYU Grossman School of Medicine, New York, NY, USA.; Interdisciplinary Melanoma Cooperative Group, Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Jame-Chenarboo+F%22">Jame-Chenarboo F</searchLink>; Department of Chemistry, University of Alberta, Edmonton, Canada.<br /><searchLink fieldCode="AU" term="%22Kar+S%22">Kar S</searchLink>; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA.<br /><searchLink fieldCode="AU" term="%22Yanke+AF%22">Yanke AF</searchLink>; Department of Pathology, NYU Grossman School of Medicine, New York, NY, USA.; Interdisciplinary Melanoma Cooperative Group, Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Berico+P%22">Berico P</searchLink>; Department of Pathology, NYU Grossman School of Medicine, New York, NY, USA.; Interdisciplinary Melanoma Cooperative Group, Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22de+Vega+EMS%22">de Vega EMS</searchLink>; Department of Dermatology, NYU Grossman School of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Darvishian+F%22">Darvishian F</searchLink>; Department of Pathology, NYU Grossman School of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Osman+I%22">Osman I</searchLink>; Interdisciplinary Melanoma Cooperative Group, Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA.; Department of Dermatology, NYU Grossman School of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Lujambio+A%22">Lujambio A</searchLink>; Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Mahal+LK%22">Mahal LK</searchLink>; Department of Chemistry, New York University, New York, NY, USA.; Department of Chemistry, University of Alberta, Edmonton, Canada.<br /><searchLink fieldCode="AU" term="%22Hernando+E%22">Hernando E</searchLink>; Department of Pathology, NYU Grossman School of Medicine, New York, NY, USA.; Interdisciplinary Melanoma Cooperative Group, Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA.
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