Methylome analysis of FTLD patients with TDP-43 pathology identifies epigenetic signatures specific to pathological subtypes.
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| Title: | Methylome analysis of FTLD patients with TDP-43 pathology identifies epigenetic signatures specific to pathological subtypes. |
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| Authors: | Vicente CT; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.; VIB Center for Molecular Neurology, VIB, Antwerp, Belgium., Niranjan T; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.; VIB Center for Molecular Neurology, VIB, Antwerp, Belgium., Coopman E; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.; VIB Center for Molecular Neurology, VIB, Antwerp, Belgium., Faura J; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.; VIB Center for Molecular Neurology, VIB, Antwerp, Belgium., Alidadiani S; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.; VIB Center for Molecular Neurology, VIB, Antwerp, Belgium., Schrauwen C; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.; VIB Center for Molecular Neurology, VIB, Antwerp, Belgium., Matchett BJ; Division of Neuroscience, University of Manchester, Manchester, UK.; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Heeman B; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.; VIB Center for Molecular Neurology, VIB, Antwerp, Belgium., Van den Broeck M; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.; VIB Center for Molecular Neurology, VIB, Antwerp, Belgium., De Coster W; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.; VIB Center for Molecular Neurology, VIB, Antwerp, Belgium., Nguyen T; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Lau JS; Genome Analysis Core, Mayo Clinic, Rochester, MN, USA., Baheti S; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA., de Pooter T; Neuromics Support Facility, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.; Neuromics Support Facility, Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium., De Rijk P; Neuromics Support Facility, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.; Neuromics Support Facility, Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium., Strazisar M; Neuromics Support Facility, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.; Neuromics Support Facility, Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium., Baker M; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., DeJesus-Hernandez M; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Finch NA; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.; Department of Neurology, Vanderbilt University Medical Center, Neuromuscular Division, Nashville, TN, USA., Pottier C; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.; VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St Louis, MO, USA., van Blitterswijk M; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Asmann Y; Department of Health Sciences Research, Mayo Clinic, Jacksonville, FL, USA., Murray ME; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Petrucelli L; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., King A; Department of Basic and Clinical Neuroscience, London Neurodegenerative Diseases Brain Bank, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; Department of Clinical Neuropathology, King's College Hospital NHS Foundation Trust, London, UK., Troakes C; Department of Basic and Clinical Neuroscience, London Neurodegenerative Diseases Brain Bank, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Al-Sarraj S; Department of Basic and Clinical Neuroscience, London Neurodegenerative Diseases Brain Bank, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; King's College Hospital NHS Foundation Trust, London, UK., Rissman RA; Department of Neurosciences, University of California San Diego, San Diego, CA, USA.; Veterans Affairs San Diego Healthcare System, San Diego, CA, USA., Hiniker A; Department of Pathology, University of Southern California, Los Angeles, CA, USA., Flanagan M; University of Texas Health Science Center San Antonio, San Antonio, TX, USA., Evers BM; Division of Neuropathology, University of Texas Southwestern Medical Center, Dallas, TX, USA., White CL 3rd; Division of Neuropathology, University of Texas Southwestern Medical Center, Dallas, TX, USA., Cruchaga C; Department of Psychiatry, Knight Alzheimer Disease Research Center, Washington University School of Medicine, Saint Louis, MO, USA., Castellani R; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., van Rooij JGJ; Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands., Mol MO; Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands., Seelaar H; Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands., van Swieten JC; Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands., Oskarsson B; Department of Neurology, Mayo Clinic, Jacksonville, FL, USA., Reichard RR; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA., Nguyen AT; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA., Josephs KA; Department of Neurology, Mayo Clinic, Rochester, MN, USA., Petersen RC; Department of Neurology, Mayo Clinic, Rochester, MN, USA., Ertekin-Taner N; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.; Department of Neurology, Mayo Clinic, Jacksonville, FL, USA., Boeve BF; Department of Neurology, Mayo Clinic, Rochester, MN, USA., Graff-Radford NR; Department of Neurology, Mayo Clinic, Jacksonville, FL, USA., Weckhuysen S; VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.; Department of Neurology, Antwerp University Hospital, Antwerp, Belgium.; Translational Neurosciences, Faculty of Medicine and Health Science, University of Antwerp, Antwerp, Belgium., Dickson DW; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Rademakers R; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium. rosa.rademakers@uantwerpen.vib.be.; VIB Center for Molecular Neurology, VIB, Antwerp, Belgium. rosa.rademakers@uantwerpen.vib.be.; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA. rosa.rademakers@uantwerpen.vib.be. |
| Source: | Molecular neurodegeneration [Mol Neurodegener] 2025 Jul 06; Vol. 20 (1), pp. 80. Date of Electronic Publication: 2025 Jul 06. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: BioMed Central Country of Publication: England NLM ID: 101266600 Publication Model: Electronic Cited Medium: Internet ISSN: 1750-1326 (Electronic) Linking ISSN: 17501326 NLM ISO Abbreviation: Mol Neurodegener Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1750-1326 |
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| DOI: | 10.1186/s13024-025-00869-2 |
