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An aminosterol breaks the autocatalytic cycle of Aβ42 aggregation and protects cell membranes from its soluble aggregates.

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Bibliographic Details
Title: An aminosterol breaks the autocatalytic cycle of Aβ42 aggregation and protects cell membranes from its soluble aggregates.
Authors: Fallot LB; Department of Chemistry and Life Science, United States Military Academy, West Point, NY 10996.; Photonics Research Center, United States Military Academy, West Point, NY 10996., Pinc JR; Department of Chemistry and Life Science, United States Military Academy, West Point, NY 10996., Buselmeier JE; Department of Chemistry and Life Science, United States Military Academy, West Point, NY 10996., Palchak JC; Department of Chemistry and Life Science, United States Military Academy, West Point, NY 10996., Shroff SS; Department of Chemistry and Life Science, United States Military Academy, West Point, NY 10996., Zang K; Department of Chemistry and Life Science, United States Military Academy, West Point, NY 10996., Rinauro DJ; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom., Bacon KM; Department of Chemistry and Life Science, United States Military Academy, West Point, NY 10996., Nguyen M; Department of Chemistry and Life Science, United States Military Academy, West Point, NY 10996., Schleck MC; Department of Chemistry and Life Science, United States Military Academy, West Point, NY 10996., Cornell AR; Department of Chemistry and Life Science, United States Military Academy, West Point, NY 10996., Oshidar A; Department of Chemistry and Life Science, United States Military Academy, West Point, NY 10996., Darrell DJ; Department of Chemistry and Life Science, United States Military Academy, West Point, NY 10996., Gabriel JM; Department of Chemistry and Life Science, United States Military Academy, West Point, NY 10996., Wright AK; Department of Chemistry and Life Science, United States Military Academy, West Point, NY 10996., Sasser LR; Department of Chemistry and Life Science, United States Military Academy, West Point, NY 10996., Kreiser RP; Department of Chemistry and Life Science, United States Military Academy, West Point, NY 10996., Burpo FJ; Department of Chemistry and Life Science, United States Military Academy, West Point, NY 10996.; Photonics Research Center, United States Military Academy, West Point, NY 10996., Santambrogio A; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom., Xu P; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom., Kubiak RW 2nd; Department of Chemistry and Life Science, United States Military Academy, West Point, NY 10996., Loverde J; Department of Chemistry and Life Science, United States Military Academy, West Point, NY 10996., Jaffett VA; Department of Chemistry and Life Science, United States Military Academy, West Point, NY 10996.; Photonics Research Center, United States Military Academy, West Point, NY 10996., Toole JR; Department of Chemistry and Life Science, United States Military Academy, West Point, NY 10996., Barbut D; BAZ Therapeutics, Inc., Philadelphia, PA 19103., Zasloff M; BAZ Therapeutics, Inc., Philadelphia, PA 19103.; MedStar-Georgetown Transplant Institute, Georgetown University School of Medicine, Washington, DC 20010., Chiti F; Section of Biochemistry, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence 50134, Italy., Dear AJ; Department of Biology, Institute of Biochemistry, ETH Zurich, Zurich 8093, Switzerland.; Bringing Materials to Life Initiative, ETH Zurich, Zurich 8093, Switzerland., Vendruscolo M; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom., Limbocker R; Department of Chemistry and Life Science, United States Military Academy, West Point, NY 10996.; Photonics Research Center, United States Military Academy, West Point, NY 10996.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Jul 15; Vol. 122 (28), pp. e2417944122. Date of Electronic Publication: 2025 Jul 07.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1091-6490
DOI:10.1073/pnas.2417944122