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An aminosterol breaks the autocatalytic cycle of Aβ42 aggregation and protects cell membranes from its soluble aggregates.

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Title: An aminosterol breaks the autocatalytic cycle of Aβ42 aggregation and protects cell membranes from its soluble aggregates.
Authors: Fallot LB; Department of Chemistry and Life Science, United States Military Academy, West Point, NY 10996.; Photonics Research Center, United States Military Academy, West Point, NY 10996., Pinc JR; Department of Chemistry and Life Science, United States Military Academy, West Point, NY 10996., Buselmeier JE; Department of Chemistry and Life Science, United States Military Academy, West Point, NY 10996., Palchak JC; Department of Chemistry and Life Science, United States Military Academy, West Point, NY 10996., Shroff SS; Department of Chemistry and Life Science, United States Military Academy, West Point, NY 10996., Zang K; Department of Chemistry and Life Science, United States Military Academy, West Point, NY 10996., Rinauro DJ; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom., Bacon KM; Department of Chemistry and Life Science, United States Military Academy, West Point, NY 10996., Nguyen M; Department of Chemistry and Life Science, United States Military Academy, West Point, NY 10996., Schleck MC; Department of Chemistry and Life Science, United States Military Academy, West Point, NY 10996., Cornell AR; Department of Chemistry and Life Science, United States Military Academy, West Point, NY 10996., Oshidar A; Department of Chemistry and Life Science, United States Military Academy, West Point, NY 10996., Darrell DJ; Department of Chemistry and Life Science, United States Military Academy, West Point, NY 10996., Gabriel JM; Department of Chemistry and Life Science, United States Military Academy, West Point, NY 10996., Wright AK; Department of Chemistry and Life Science, United States Military Academy, West Point, NY 10996., Sasser LR; Department of Chemistry and Life Science, United States Military Academy, West Point, NY 10996., Kreiser RP; Department of Chemistry and Life Science, United States Military Academy, West Point, NY 10996., Burpo FJ; Department of Chemistry and Life Science, United States Military Academy, West Point, NY 10996.; Photonics Research Center, United States Military Academy, West Point, NY 10996., Santambrogio A; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom., Xu P; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom., Kubiak RW 2nd; Department of Chemistry and Life Science, United States Military Academy, West Point, NY 10996., Loverde J; Department of Chemistry and Life Science, United States Military Academy, West Point, NY 10996., Jaffett VA; Department of Chemistry and Life Science, United States Military Academy, West Point, NY 10996.; Photonics Research Center, United States Military Academy, West Point, NY 10996., Toole JR; Department of Chemistry and Life Science, United States Military Academy, West Point, NY 10996., Barbut D; BAZ Therapeutics, Inc., Philadelphia, PA 19103., Zasloff M; BAZ Therapeutics, Inc., Philadelphia, PA 19103.; MedStar-Georgetown Transplant Institute, Georgetown University School of Medicine, Washington, DC 20010., Chiti F; Section of Biochemistry, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence 50134, Italy., Dear AJ; Department of Biology, Institute of Biochemistry, ETH Zurich, Zurich 8093, Switzerland.; Bringing Materials to Life Initiative, ETH Zurich, Zurich 8093, Switzerland., Vendruscolo M; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom., Limbocker R; Department of Chemistry and Life Science, United States Military Academy, West Point, NY 10996.; Photonics Research Center, United States Military Academy, West Point, NY 10996.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Jul 15; Vol. 122 (28), pp. e2417944122. Date of Electronic Publication: 2025 Jul 07.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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  Data: An aminosterol breaks the autocatalytic cycle of Aβ<subscript>42</subscript> aggregation and protects cell membranes from its soluble aggregates.
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Department of Chemistry and Life Science, United States Military Academy, West Point, NY 10996.<br /><searchLink fieldCode="AU" term="%22Rinauro+DJ%22">Rinauro DJ</searchLink>; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Bacon+KM%22">Bacon KM</searchLink>; Department of Chemistry and Life Science, United States Military Academy, West Point, NY 10996.<br /><searchLink fieldCode="AU" term="%22Nguyen+M%22">Nguyen M</searchLink>; Department of Chemistry and Life Science, United States Military Academy, West Point, NY 10996.<br /><searchLink fieldCode="AU" term="%22Schleck+MC%22">Schleck MC</searchLink>; Department of Chemistry and Life Science, United States Military Academy, West Point, NY 10996.<br /><searchLink fieldCode="AU" term="%22Cornell+AR%22">Cornell AR</searchLink>; Department of Chemistry and Life Science, United States Military Academy, West Point, NY 10996.<br /><searchLink fieldCode="AU" term="%22Oshidar+A%22">Oshidar A</searchLink>; 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Department of Chemistry and Life Science, United States Military Academy, West Point, NY 10996.; Photonics Research Center, United States Military Academy, West Point, NY 10996.<br /><searchLink fieldCode="AU" term="%22Santambrogio+A%22">Santambrogio A</searchLink>; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Xu+P%22">Xu P</searchLink>; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Kubiak+RW+2nd%22">Kubiak RW 2nd</searchLink>; Department of Chemistry and Life Science, United States Military Academy, West Point, NY 10996.<br /><searchLink fieldCode="AU" term="%22Loverde+J%22">Loverde J</searchLink>; Department of Chemistry and Life Science, United States Military Academy, West Point, NY 10996.<br /><searchLink fieldCode="AU" term="%22Jaffett+VA%22">Jaffett VA</searchLink>; Department of Chemistry and Life Science, United States Military Academy, West Point, NY 10996.; Photonics Research Center, United States Military Academy, West Point, NY 10996.<br /><searchLink fieldCode="AU" term="%22Toole+JR%22">Toole JR</searchLink>; Department of Chemistry and Life Science, United States Military Academy, West Point, NY 10996.<br /><searchLink fieldCode="AU" term="%22Barbut+D%22">Barbut D</searchLink>; BAZ Therapeutics, Inc., Philadelphia, PA 19103.<br /><searchLink fieldCode="AU" term="%22Zasloff+M%22">Zasloff M</searchLink>; BAZ Therapeutics, Inc., Philadelphia, PA 19103.; MedStar-Georgetown Transplant Institute, Georgetown University School of Medicine, Washington, DC 20010.<br /><searchLink fieldCode="AU" term="%22Chiti+F%22">Chiti F</searchLink>; Section of Biochemistry, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence 50134, Italy.<br /><searchLink fieldCode="AU" term="%22Dear+AJ%22">Dear AJ</searchLink>; Department of Biology, Institute of Biochemistry, ETH Zurich, Zurich 8093, Switzerland.; Bringing Materials to Life Initiative, ETH Zurich, Zurich 8093, Switzerland.<br /><searchLink fieldCode="AU" term="%22Vendruscolo+M%22">Vendruscolo M</searchLink>; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Limbocker+R%22">Limbocker R</searchLink>; Department of Chemistry and Life Science, United States Military Academy, West Point, NY 10996.; Photonics Research Center, United States Military Academy, West Point, NY 10996.
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