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Inhibition of the minor spliceosome restricts the growth of a broad spectrum of cancers.

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Title: Inhibition of the minor spliceosome restricts the growth of a broad spectrum of cancers.
Authors: Doggett K; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia. doggett.k@wehi.edu.au.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia. doggett.k@wehi.edu.au., Morgan KJ; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia., Olthof AM; Physiology and Neurobiology Department, University of Connecticut, Storrs, CT, 06269, USA.; Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark., Mieruszynski S; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia., Williams BB; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia., Garnham AL; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia., Milevskiy MJG; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia., Whitehead L; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia., Coates J; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia., Buchert M; Cancer and Inflammation Laboratory, Olivia Newton-John Cancer Research Institute, Heidelberg, VIC, 3084, Australia.; La Trobe University School of Cancer Medicine, Heidelberg, VIC, 3084, Australia., O'Donoghue RJJ; Cancer and Inflammation Laboratory, Olivia Newton-John Cancer Research Institute, Heidelberg, VIC, 3084, Australia.; La Trobe University School of Cancer Medicine, Heidelberg, VIC, 3084, Australia., Hall TE; Institute for Molecular Bioscience, University of Queensland, St Lucia, QLD, 4072, Australia., Putoczki TL; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia., Ernst M; Cancer and Inflammation Laboratory, Olivia Newton-John Cancer Research Institute, Heidelberg, VIC, 3084, Australia.; La Trobe University School of Cancer Medicine, Heidelberg, VIC, 3084, Australia., Sutherland KD; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia., Kanadia RN; Physiology and Neurobiology Department, University of Connecticut, Storrs, CT, 06269, USA.; Institute for Systems Genomics, University of Connecticut, Storrs, CT, 06269, USA., Heath JK; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia.
Source: EMBO reports [EMBO Rep] 2025 Aug; Vol. 26 (15), pp. 3937-3969. Date of Electronic Publication: 2025 Jul 07.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 100963049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-3178 (Electronic) Linking ISSN: 1469221X NLM ISO Abbreviation: EMBO Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Doggett+K%22">Doggett K</searchLink>; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia. doggett.k@wehi.edu.au.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia. doggett.k@wehi.edu.au.<br /><searchLink fieldCode="AU" term="%22Morgan+KJ%22">Morgan KJ</searchLink>; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Olthof+AM%22">Olthof AM</searchLink>; Physiology and Neurobiology Department, University of Connecticut, Storrs, CT, 06269, USA.; Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Mieruszynski+S%22">Mieruszynski S</searchLink>; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Williams+BB%22">Williams BB</searchLink>; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Garnham+AL%22">Garnham AL</searchLink>; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Milevskiy+MJG%22">Milevskiy MJG</searchLink>; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Whitehead+L%22">Whitehead L</searchLink>; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Coates+J%22">Coates J</searchLink>; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Buchert+M%22">Buchert M</searchLink>; Cancer and Inflammation Laboratory, Olivia Newton-John Cancer Research Institute, Heidelberg, VIC, 3084, Australia.; La Trobe University School of Cancer Medicine, Heidelberg, VIC, 3084, Australia.<br /><searchLink fieldCode="AU" term="%22O'Donoghue+RJJ%22">O'Donoghue RJJ</searchLink>; Cancer and Inflammation Laboratory, Olivia Newton-John Cancer Research Institute, Heidelberg, VIC, 3084, Australia.; La Trobe University School of Cancer Medicine, Heidelberg, VIC, 3084, Australia.<br /><searchLink fieldCode="AU" term="%22Hall+TE%22">Hall TE</searchLink>; Institute for Molecular Bioscience, University of Queensland, St Lucia, QLD, 4072, Australia.<br /><searchLink fieldCode="AU" term="%22Putoczki+TL%22">Putoczki TL</searchLink>; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Ernst+M%22">Ernst M</searchLink>; Cancer and Inflammation Laboratory, Olivia Newton-John Cancer Research Institute, Heidelberg, VIC, 3084, Australia.; La Trobe University School of Cancer Medicine, Heidelberg, VIC, 3084, Australia.<br /><searchLink fieldCode="AU" term="%22Sutherland+KD%22">Sutherland KD</searchLink>; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Kanadia+RN%22">Kanadia RN</searchLink>; Physiology and Neurobiology Department, University of Connecticut, Storrs, CT, 06269, USA.; Institute for Systems Genomics, University of Connecticut, Storrs, CT, 06269, USA.<br /><searchLink fieldCode="AU" term="%22Heath+JK%22">Heath JK</searchLink>; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia.
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  Data: <searchLink fieldCode="JN" term="%22100963049%22">EMBO reports</searchLink> [EMBO Rep] 2025 Aug; Vol. 26 (15), pp. 3937-3969. <i>Date of Electronic Publication: </i>2025 Jul 07.
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