Factor analysis of multimodal MRI, biofluid, and vascular biomarkers reveals latent constructs of brain health.

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Title: Factor analysis of multimodal MRI, biofluid, and vascular biomarkers reveals latent constructs of brain health.
Authors: Rowsthorn E; Department of Neuroscience, School of Translational Medicine, Monash University, 99 Commercial Road, Melbourne, VIC, 3004, Australia.; School of Psychological Sciences and Turner Institute for Brain and Mental Health, Monash University, 18 Innovation Walk, Clayton, VIC, 3168, Australia., Sim MA; School of Psychological Sciences and Turner Institute for Brain and Mental Health, Monash University, 18 Innovation Walk, Clayton, VIC, 3168, Australia.; National University Health System, National University Hospital, 1E Kent Ridge Rd, Kent Ridge, 119228, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore, 10 Medical Dr, Kent Ridge, 117597, Singapore., O'Brien WT; Department of Neuroscience, School of Translational Medicine, Monash University, 99 Commercial Road, Melbourne, VIC, 3004, Australia., McDonald SJ; Department of Neuroscience, School of Translational Medicine, Monash University, 99 Commercial Road, Melbourne, VIC, 3004, Australia., Franks K; School of Psychological Sciences and Turner Institute for Brain and Mental Health, Monash University, 18 Innovation Walk, Clayton, VIC, 3168, Australia., Sinclair B; Department of Neuroscience, School of Translational Medicine, Monash University, 99 Commercial Road, Melbourne, VIC, 3004, Australia., Chong TT; School of Psychological Sciences and Turner Institute for Brain and Mental Health, Monash University, 18 Innovation Walk, Clayton, VIC, 3168, Australia.; Department of Neurology, Alfred Health, 55 Commercial Road, Melbourne, VIC, 3004, Australia.; Department of Clinical Neurosciences, St Vincent's Hospital, 41 Victoria Parade, Fitzroy, VIC, 3065, Australia., Yiallourou S; School of Psychological Sciences and Turner Institute for Brain and Mental Health, Monash University, 18 Innovation Walk, Clayton, VIC, 3168, Australia., Cavuoto M; School of Psychological Sciences and Turner Institute for Brain and Mental Health, Monash University, 18 Innovation Walk, Clayton, VIC, 3168, Australia.; National Ageing Research Institute, The Royal Melbourne Hospital, 34-54 Poplar Road, Parkville, VIC, 3052, Australia., Vivash L; Department of Neuroscience, School of Translational Medicine, Monash University, 99 Commercial Road, Melbourne, VIC, 3004, Australia., O'Brien TJ; Department of Neuroscience, School of Translational Medicine, Monash University, 99 Commercial Road, Melbourne, VIC, 3004, Australia., Shao X; Laboratory of FMRI Technology (LOFT), Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, CA, 90033, USA., Wang DJJ; Laboratory of FMRI Technology (LOFT), Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, CA, 90033, USA., Law M; Department of Neuroscience, School of Translational Medicine, Monash University, 99 Commercial Road, Melbourne, VIC, 3004, Australia.; Department of Radiology, Alfred Health, 99 Commercial Road, Melbourne, VIC, 3004, Australia.; Department of Electrical and Computer Systems Engineering, Monash University, 14 Alliance Lane, Clayton, VIC, 3168, Australia., Harding IH; Department of Neuroscience, School of Translational Medicine, Monash University, 99 Commercial Road, Melbourne, VIC, 3004, Australia.; QIMR Berghofer Medical Research Institute, 300 Herston Rd, Herston, Brisbane, QLD, 4006, Australia., Pase MP; School of Psychological Sciences and Turner Institute for Brain and Mental Health, Monash University, 18 Innovation Walk, Clayton, VIC, 3168, Australia. matthew.pase@monash.edu.
Source: GeroScience [Geroscience] 2026 Apr; Vol. 48 (2), pp. 1885-1903. Date of Electronic Publication: 2025 Jul 08.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101686284 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2509-2723 (Electronic) Linking ISSN: 25092723 NLM ISO Abbreviation: Geroscience Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2509-2723
DOI:10.1007/s11357-025-01771-x