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Factor analysis of multimodal MRI, biofluid, and vascular biomarkers reveals latent constructs of brain health.

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Title: Factor analysis of multimodal MRI, biofluid, and vascular biomarkers reveals latent constructs of brain health.
Authors: Rowsthorn E; Department of Neuroscience, School of Translational Medicine, Monash University, 99 Commercial Road, Melbourne, VIC, 3004, Australia.; School of Psychological Sciences and Turner Institute for Brain and Mental Health, Monash University, 18 Innovation Walk, Clayton, VIC, 3168, Australia., Sim MA; School of Psychological Sciences and Turner Institute for Brain and Mental Health, Monash University, 18 Innovation Walk, Clayton, VIC, 3168, Australia.; National University Health System, National University Hospital, 1E Kent Ridge Rd, Kent Ridge, 119228, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore, 10 Medical Dr, Kent Ridge, 117597, Singapore., O'Brien WT; Department of Neuroscience, School of Translational Medicine, Monash University, 99 Commercial Road, Melbourne, VIC, 3004, Australia., McDonald SJ; Department of Neuroscience, School of Translational Medicine, Monash University, 99 Commercial Road, Melbourne, VIC, 3004, Australia., Franks K; School of Psychological Sciences and Turner Institute for Brain and Mental Health, Monash University, 18 Innovation Walk, Clayton, VIC, 3168, Australia., Sinclair B; Department of Neuroscience, School of Translational Medicine, Monash University, 99 Commercial Road, Melbourne, VIC, 3004, Australia., Chong TT; School of Psychological Sciences and Turner Institute for Brain and Mental Health, Monash University, 18 Innovation Walk, Clayton, VIC, 3168, Australia.; Department of Neurology, Alfred Health, 55 Commercial Road, Melbourne, VIC, 3004, Australia.; Department of Clinical Neurosciences, St Vincent's Hospital, 41 Victoria Parade, Fitzroy, VIC, 3065, Australia., Yiallourou S; School of Psychological Sciences and Turner Institute for Brain and Mental Health, Monash University, 18 Innovation Walk, Clayton, VIC, 3168, Australia., Cavuoto M; School of Psychological Sciences and Turner Institute for Brain and Mental Health, Monash University, 18 Innovation Walk, Clayton, VIC, 3168, Australia.; National Ageing Research Institute, The Royal Melbourne Hospital, 34-54 Poplar Road, Parkville, VIC, 3052, Australia., Vivash L; Department of Neuroscience, School of Translational Medicine, Monash University, 99 Commercial Road, Melbourne, VIC, 3004, Australia., O'Brien TJ; Department of Neuroscience, School of Translational Medicine, Monash University, 99 Commercial Road, Melbourne, VIC, 3004, Australia., Shao X; Laboratory of FMRI Technology (LOFT), Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, CA, 90033, USA., Wang DJJ; Laboratory of FMRI Technology (LOFT), Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, CA, 90033, USA., Law M; Department of Neuroscience, School of Translational Medicine, Monash University, 99 Commercial Road, Melbourne, VIC, 3004, Australia.; Department of Radiology, Alfred Health, 99 Commercial Road, Melbourne, VIC, 3004, Australia.; Department of Electrical and Computer Systems Engineering, Monash University, 14 Alliance Lane, Clayton, VIC, 3168, Australia., Harding IH; Department of Neuroscience, School of Translational Medicine, Monash University, 99 Commercial Road, Melbourne, VIC, 3004, Australia.; QIMR Berghofer Medical Research Institute, 300 Herston Rd, Herston, Brisbane, QLD, 4006, Australia., Pase MP; School of Psychological Sciences and Turner Institute for Brain and Mental Health, Monash University, 18 Innovation Walk, Clayton, VIC, 3168, Australia. matthew.pase@monash.edu.
Source: GeroScience [Geroscience] 2026 Apr; Vol. 48 (2), pp. 1885-1903. Date of Electronic Publication: 2025 Jul 08.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101686284 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2509-2723 (Electronic) Linking ISSN: 25092723 NLM ISO Abbreviation: Geroscience Subsets: MEDLINE
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  Data: Factor analysis of multimodal MRI, biofluid, and vascular biomarkers reveals latent constructs of brain health.
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  Data: <searchLink fieldCode="AU" term="%22Rowsthorn+E%22">Rowsthorn E</searchLink>; Department of Neuroscience, School of Translational Medicine, Monash University, 99 Commercial Road, Melbourne, VIC, 3004, Australia.; School of Psychological Sciences and Turner Institute for Brain and Mental Health, Monash University, 18 Innovation Walk, Clayton, VIC, 3168, Australia.<br /><searchLink fieldCode="AU" term="%22Sim+MA%22">Sim MA</searchLink>; School of Psychological Sciences and Turner Institute for Brain and Mental Health, Monash University, 18 Innovation Walk, Clayton, VIC, 3168, Australia.; National University Health System, National University Hospital, 1E Kent Ridge Rd, Kent Ridge, 119228, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore, 10 Medical Dr, Kent Ridge, 117597, Singapore.<br /><searchLink fieldCode="AU" term="%22O'Brien+WT%22">O'Brien WT</searchLink>; Department of Neuroscience, School of Translational Medicine, Monash University, 99 Commercial Road, Melbourne, VIC, 3004, Australia.<br /><searchLink fieldCode="AU" term="%22McDonald+SJ%22">McDonald SJ</searchLink>; Department of Neuroscience, School of Translational Medicine, Monash University, 99 Commercial Road, Melbourne, VIC, 3004, Australia.<br /><searchLink fieldCode="AU" term="%22Franks+K%22">Franks K</searchLink>; School of Psychological Sciences and Turner Institute for Brain and Mental Health, Monash University, 18 Innovation Walk, Clayton, VIC, 3168, Australia.<br /><searchLink fieldCode="AU" term="%22Sinclair+B%22">Sinclair B</searchLink>; Department of Neuroscience, School of Translational Medicine, Monash University, 99 Commercial Road, Melbourne, VIC, 3004, Australia.<br /><searchLink fieldCode="AU" term="%22Chong+TT%22">Chong TT</searchLink>; School of Psychological Sciences and Turner Institute for Brain and Mental Health, Monash University, 18 Innovation Walk, Clayton, VIC, 3168, Australia.; Department of Neurology, Alfred Health, 55 Commercial Road, Melbourne, VIC, 3004, Australia.; Department of Clinical Neurosciences, St Vincent's Hospital, 41 Victoria Parade, Fitzroy, VIC, 3065, Australia.<br /><searchLink fieldCode="AU" term="%22Yiallourou+S%22">Yiallourou S</searchLink>; School of Psychological Sciences and Turner Institute for Brain and Mental Health, Monash University, 18 Innovation Walk, Clayton, VIC, 3168, Australia.<br /><searchLink fieldCode="AU" term="%22Cavuoto+M%22">Cavuoto M</searchLink>; School of Psychological Sciences and Turner Institute for Brain and Mental Health, Monash University, 18 Innovation Walk, Clayton, VIC, 3168, Australia.; National Ageing Research Institute, The Royal Melbourne Hospital, 34-54 Poplar Road, Parkville, VIC, 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Vivash+L%22">Vivash L</searchLink>; Department of Neuroscience, School of Translational Medicine, Monash University, 99 Commercial Road, Melbourne, VIC, 3004, Australia.<br /><searchLink fieldCode="AU" term="%22O'Brien+TJ%22">O'Brien TJ</searchLink>; Department of Neuroscience, School of Translational Medicine, Monash University, 99 Commercial Road, Melbourne, VIC, 3004, Australia.<br /><searchLink fieldCode="AU" term="%22Shao+X%22">Shao X</searchLink>; Laboratory of FMRI Technology (LOFT), Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, CA, 90033, USA.<br /><searchLink fieldCode="AU" term="%22Wang+DJJ%22">Wang DJJ</searchLink>; Laboratory of FMRI Technology (LOFT), Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, CA, 90033, USA.<br /><searchLink fieldCode="AU" term="%22Law+M%22">Law M</searchLink>; Department of Neuroscience, School of Translational Medicine, Monash University, 99 Commercial Road, Melbourne, VIC, 3004, Australia.; Department of Radiology, Alfred Health, 99 Commercial Road, Melbourne, VIC, 3004, Australia.; Department of Electrical and Computer Systems Engineering, Monash University, 14 Alliance Lane, Clayton, VIC, 3168, Australia.<br /><searchLink fieldCode="AU" term="%22Harding+IH%22">Harding IH</searchLink>; Department of Neuroscience, School of Translational Medicine, Monash University, 99 Commercial Road, Melbourne, VIC, 3004, Australia.; QIMR Berghofer Medical Research Institute, 300 Herston Rd, Herston, Brisbane, QLD, 4006, Australia.<br /><searchLink fieldCode="AU" term="%22Pase+MP%22">Pase MP</searchLink>; School of Psychological Sciences and Turner Institute for Brain and Mental Health, Monash University, 18 Innovation Walk, Clayton, VIC, 3168, Australia. matthew.pase@monash.edu.
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  Data: <searchLink fieldCode="JN" term="%22101686284%22">GeroScience</searchLink> [Geroscience] 2026 Apr; Vol. 48 (2), pp. 1885-1903. <i>Date of Electronic Publication: </i>2025 Jul 08.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+International+Publishing%22">Springer International Publishing </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101686284 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2509-2723 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2225092723%22">25092723 </searchLink><i>NLM ISO Abbreviation: </i>Geroscience <i>Subsets: </i>MEDLINE
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