Smoking initiation as a mediator: investigating the causal relationship between sedentary lifestyles and cannabis use disorder through Mendelian randomization.

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Title: Smoking initiation as a mediator: investigating the causal relationship between sedentary lifestyles and cannabis use disorder through Mendelian randomization.
Authors: Meng D; Division of Computational Biology, Chinese Center of Exercise Epidemiology, Northeast Normal University, Changchun, China., Wei M; Division of Computational Biology, Chinese Center of Exercise Epidemiology, Northeast Normal University, Changchun, China.; School of Physical Education, Changchun University, Changchun, China., He S; Division of Computational Biology, Chinese Center of Exercise Epidemiology, Northeast Normal University, Changchun, China.; Graduate School of Health Management, Keio University, Kanagawa, Japan.; Sports Medicine Research Center, Keio University, Kanagawa, Japan., Lv Z; Department of Adolescent Physical Health, Chinese Center of Exercise Epidemiology, Northeast Normal University, Changchun, China., Zhang H; Department of Adolescent Physical Health, Chinese Center of Exercise Epidemiology, Northeast Normal University, Changchun, China., Yang G; Division of Computational Biology, Chinese Center of Exercise Epidemiology, Northeast Normal University, Changchun, China.; Department of Adolescent Physical Health, Chinese Center of Exercise Epidemiology, Northeast Normal University, Changchun, China., Wang Z; Division of Computational Biology, Chinese Center of Exercise Epidemiology, Northeast Normal University, Changchun, China.; AI group, Intelligent Lancet LLC, Sacramento, CA, USA.; Advanced Research Center for Human Sciences, Waseda University, Tokorozawa, Japan.
Source: Journal of addictive diseases [J Addict Dis] 2026 Jul-Sep; Vol. 44 (3), pp. 267-277. Date of Electronic Publication: 2025 Jul 09.
Publication Type: Journal Article
Journal Info: Publisher: Informa Healthcare Country of Publication: England NLM ID: 9107051 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-0848 (Electronic) Linking ISSN: 10550887 NLM ISO Abbreviation: J Addict Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1545-0848
DOI:10.1080/10550887.2025.2516290