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Smoking initiation as a mediator: investigating the causal relationship between sedentary lifestyles and cannabis use disorder through Mendelian randomization.

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Title: Smoking initiation as a mediator: investigating the causal relationship between sedentary lifestyles and cannabis use disorder through Mendelian randomization.
Authors: Meng D; Division of Computational Biology, Chinese Center of Exercise Epidemiology, Northeast Normal University, Changchun, China., Wei M; Division of Computational Biology, Chinese Center of Exercise Epidemiology, Northeast Normal University, Changchun, China.; School of Physical Education, Changchun University, Changchun, China., He S; Division of Computational Biology, Chinese Center of Exercise Epidemiology, Northeast Normal University, Changchun, China.; Graduate School of Health Management, Keio University, Kanagawa, Japan.; Sports Medicine Research Center, Keio University, Kanagawa, Japan., Lv Z; Department of Adolescent Physical Health, Chinese Center of Exercise Epidemiology, Northeast Normal University, Changchun, China., Zhang H; Department of Adolescent Physical Health, Chinese Center of Exercise Epidemiology, Northeast Normal University, Changchun, China., Yang G; Division of Computational Biology, Chinese Center of Exercise Epidemiology, Northeast Normal University, Changchun, China.; Department of Adolescent Physical Health, Chinese Center of Exercise Epidemiology, Northeast Normal University, Changchun, China., Wang Z; Division of Computational Biology, Chinese Center of Exercise Epidemiology, Northeast Normal University, Changchun, China.; AI group, Intelligent Lancet LLC, Sacramento, CA, USA.; Advanced Research Center for Human Sciences, Waseda University, Tokorozawa, Japan.
Source: Journal of addictive diseases [J Addict Dis] 2026 Jul-Sep; Vol. 44 (3), pp. 267-277. Date of Electronic Publication: 2025 Jul 09.
Publication Type: Journal Article
Journal Info: Publisher: Informa Healthcare Country of Publication: England NLM ID: 9107051 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-0848 (Electronic) Linking ISSN: 10550887 NLM ISO Abbreviation: J Addict Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Meng+D%22">Meng D</searchLink>; Division of Computational Biology, Chinese Center of Exercise Epidemiology, Northeast Normal University, Changchun, China.<br /><searchLink fieldCode="AU" term="%22Wei+M%22">Wei M</searchLink>; Division of Computational Biology, Chinese Center of Exercise Epidemiology, Northeast Normal University, Changchun, China.; School of Physical Education, Changchun University, Changchun, China.<br /><searchLink fieldCode="AU" term="%22He+S%22">He S</searchLink>; Division of Computational Biology, Chinese Center of Exercise Epidemiology, Northeast Normal University, Changchun, China.; Graduate School of Health Management, Keio University, Kanagawa, Japan.; Sports Medicine Research Center, Keio University, Kanagawa, Japan.<br /><searchLink fieldCode="AU" term="%22Lv+Z%22">Lv Z</searchLink>; Department of Adolescent Physical Health, Chinese Center of Exercise Epidemiology, Northeast Normal University, Changchun, China.<br /><searchLink fieldCode="AU" term="%22Zhang+H%22">Zhang H</searchLink>; Department of Adolescent Physical Health, Chinese Center of Exercise Epidemiology, Northeast Normal University, Changchun, China.<br /><searchLink fieldCode="AU" term="%22Yang+G%22">Yang G</searchLink>; Division of Computational Biology, Chinese Center of Exercise Epidemiology, Northeast Normal University, Changchun, China.; Department of Adolescent Physical Health, Chinese Center of Exercise Epidemiology, Northeast Normal University, Changchun, China.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; Division of Computational Biology, Chinese Center of Exercise Epidemiology, Northeast Normal University, Changchun, China.; AI group, Intelligent Lancet LLC, Sacramento, CA, USA.; Advanced Research Center for Human Sciences, Waseda University, Tokorozawa, Japan.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Informa+Healthcare%22">Informa Healthcare </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9107051 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1545-0848 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210550887%22">10550887 </searchLink><i>NLM ISO Abbreviation: </i>J Addict Dis <i>Subsets: </i>MEDLINE
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      – TitleFull: Smoking initiation as a mediator: investigating the causal relationship between sedentary lifestyles and cannabis use disorder through Mendelian randomization.
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              Text: 2026 Jul-Sep
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              Y: 2026
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