Transient Poly(ADP-Ribose) Triggers FUS Condensation Hysteresis via a Prion-Like Mechanism.

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Title: Transient Poly(ADP-Ribose) Triggers FUS Condensation Hysteresis via a Prion-Like Mechanism.
Authors: Liu H; Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.; Cross-Disciplinary Graduate Program in Biomedical Sciences (XDBio), School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA., Cai Y; Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA., Shi L; Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA., Pillai M; Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA., Das N; Program in Cellular & Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA., Tarbox HE; Department of Chemistry, Johns Hopkins University, Baltimore, MD 21218, USA., Ge Y; Program in Cellular & Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA.; Thomas C. Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, MD 21218, USA., Yue K; Department of Chemistry, Tufts University, Medford, MA 02155, USA., Yang X; Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA., Rath P; Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA., Badiee M; Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA., Fabilane CS; Program in Molecular Biophysics, Johns Hopkins University, Baltimore, MD 21218, USA.; Translational Tissue Engineering Center, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA., Spangler JB; Translational Tissue Engineering Center, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.; Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.; Department of Ophthalmology, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.; Department of Molecular Microbiology & Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.; Department of Oncology, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA., Bedford MT; Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA., Myong S; Program in Cellular & Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA.; Thomas C. Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, MD 21218, USA.; Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA., Fried SD; Department of Chemistry, Johns Hopkins University, Baltimore, MD 21218, USA.; Thomas C. Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, MD 21218, USA., Ding X; Department of Chemistry, Tufts University, Medford, MA 02155, USA., Leung AKL; Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.; Translational Tissue Engineering Center, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.; Department of Molecular Biology and Genetics, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.; Department of Genetic Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.; Lead contact.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Jul 05. Date of Electronic Publication: 2025 Jul 05.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2692-8205
DOI:10.1101/2025.07.03.659157