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METTL3 overexpression and ATF6 silencing-induced Inhibition in HAS2 expression relieves PDGF-BB stimulation-induced HA production and the proliferation of human orbital fibroblasts in graves' ophthalmopathy.

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Title: METTL3 overexpression and ATF6 silencing-induced Inhibition in HAS2 expression relieves PDGF-BB stimulation-induced HA production and the proliferation of human orbital fibroblasts in graves' ophthalmopathy.
Authors: Liu SY; Department of Endocrinology, The First Affiliated Hospital of Henan Polytechnic University (The Second People's Hospital of Jiaozuo), Jiaozuo, China. liushuyan0391@163.com.; Department of Endocrinology, The First Affiliated Hospital of Henan Polytechnic University (The Second People's Hospital of Jiaozuo), Democratic South Road 17, Jiefang District, Jiaozuo, 454000, China. liushuyan0391@163.com., Wang H; Department of Gynecology, The First Affiliated Hospital of Henan Polytechnic University (The Second People's Hospital of Jiaozuo), Jiaozuo, China., Wang T; Medical Center Laboratory, The First Affiliated Hospital of Henan Polytechnic University (The Second People's Hospital of Jiaozuo), Jiaozuo, China., Zhou LF; Jiaozuo public health medical center, The Center for Disease Control and Prevention of Jiaozuo City, Jiaozuo, China., Xu XL; Jiaozuo public health medical center, The Center for Disease Control and Prevention of Jiaozuo City, Jiaozuo, China., Hou B; Medical College of Henan Polytechnic University, Jiaozuo, China., Yang B; Department of Neurology, The First Affiliated Hospital of Henan Polytechnic University (The Second People's Hospital of Jiaozuo), Jiaozuo, China., Sun LS; Department of Gynecology, The First Affiliated Hospital of Henan Polytechnic University (The Second People's Hospital of Jiaozuo), Jiaozuo, China., Pang H; Department of Oncology, The First Affiliated Hospital of Henan Polytechnic University (The Second People's Hospital of Jiaozuo), Jiaozuo, China., Wang HH; Department of Endocrinology, The First Affiliated Hospital of Henan Polytechnic University (The Second People's Hospital of Jiaozuo), Jiaozuo, China., Chen J; Department of Endocrinology, The First Affiliated Hospital of Henan Polytechnic University (The Second People's Hospital of Jiaozuo), Jiaozuo, China.
Source: Journal of endocrinological investigation [J Endocrinol Invest] 2025 Oct; Vol. 48 (10), pp. 2337-2350. Date of Electronic Publication: 2025 Jul 09.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: Italy NLM ID: 7806594 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1720-8386 (Electronic) Linking ISSN: 03914097 NLM ISO Abbreviation: J Endocrinol Invest Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1720-8386
DOI:10.1007/s40618-025-02647-9