Antitrypanosomal quinazolines targeting lysyl-tRNA synthetase show partial efficacy in a mouse model of acute Chagas disease.
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| Title: | Antitrypanosomal quinazolines targeting lysyl-tRNA synthetase show partial efficacy in a mouse model of acute Chagas disease. |
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| Authors: | Tulloch LB; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Tawell H; Department of Chemistry, Loughborough University, Loughborough LE11 3TU, UK., Taylor AE; Leicester School of Allied Health Sciences, De Montfort University, The Gateway, Leicester LE1 9BH, UK., Lima ML; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Dawson A; Drug Discovery Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Carvalho S; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Wall RJ; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Corpas-Lopez V; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Dey G; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Duggan J; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Magalhaes LG; Drug Discovery Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Torrie LS; Drug Discovery Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Frame L; Drug Discovery Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Robinson D; Drug Discovery Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Patterson S; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Tinti M; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Weaver GW; Department of Chemistry, Loughborough University, Loughborough LE11 3TU, UK., Robinson WJ; Leicester School of Allied Health Sciences, De Montfort University, The Gateway, Leicester LE1 9BH, UK., Cal M; Swiss Tropical and Public Health Institute, 4123 Allschwil, Switzerland.; University of Basel, 4003 Basel, Switzerland., Kaiser M; Swiss Tropical and Public Health Institute, 4123 Allschwil, Switzerland.; University of Basel, 4003 Basel, Switzerland., Mäser P; Swiss Tropical and Public Health Institute, 4123 Allschwil, Switzerland.; University of Basel, 4003 Basel, Switzerland., Sjö P; Drugs for Neglected Diseases Initiative (DNDi), 1202 Geneva, Switzerland., Perry B; Drugs for Neglected Diseases Initiative (DNDi), 1202 Geneva, Switzerland., Kelly JM; London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK., Francisco AF; London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK., Bhambra AS; Leicester School of Allied Health Sciences, De Montfort University, The Gateway, Leicester LE1 9BH, UK., Wyllie S; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK. |
| Source: | Science translational medicine [Sci Transl Med] 2025 Jul 09; Vol. 17 (806), pp. eadu4564. Date of Electronic Publication: 2025 Jul 09. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1946-6242 |
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| DOI: | 10.1126/scitranslmed.adu4564 |
