View in EDS HTML Full Text PDF Full Text

Antitrypanosomal quinazolines targeting lysyl-tRNA synthetase show partial efficacy in a mouse model of acute Chagas disease.

Saved in:
Bibliographic Details
Title: Antitrypanosomal quinazolines targeting lysyl-tRNA synthetase show partial efficacy in a mouse model of acute Chagas disease.
Authors: Tulloch LB; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Tawell H; Department of Chemistry, Loughborough University, Loughborough LE11 3TU, UK., Taylor AE; Leicester School of Allied Health Sciences, De Montfort University, The Gateway, Leicester LE1 9BH, UK., Lima ML; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Dawson A; Drug Discovery Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Carvalho S; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Wall RJ; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Corpas-Lopez V; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Dey G; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Duggan J; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Magalhaes LG; Drug Discovery Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Torrie LS; Drug Discovery Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Frame L; Drug Discovery Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Robinson D; Drug Discovery Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Patterson S; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Tinti M; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Weaver GW; Department of Chemistry, Loughborough University, Loughborough LE11 3TU, UK., Robinson WJ; Leicester School of Allied Health Sciences, De Montfort University, The Gateway, Leicester LE1 9BH, UK., Cal M; Swiss Tropical and Public Health Institute, 4123 Allschwil, Switzerland.; University of Basel, 4003 Basel, Switzerland., Kaiser M; Swiss Tropical and Public Health Institute, 4123 Allschwil, Switzerland.; University of Basel, 4003 Basel, Switzerland., Mäser P; Swiss Tropical and Public Health Institute, 4123 Allschwil, Switzerland.; University of Basel, 4003 Basel, Switzerland., Sjö P; Drugs for Neglected Diseases Initiative (DNDi), 1202 Geneva, Switzerland., Perry B; Drugs for Neglected Diseases Initiative (DNDi), 1202 Geneva, Switzerland., Kelly JM; London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK., Francisco AF; London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK., Bhambra AS; Leicester School of Allied Health Sciences, De Montfort University, The Gateway, Leicester LE1 9BH, UK., Wyllie S; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.
Source: Science translational medicine [Sci Transl Med] 2025 Jul 09; Vol. 17 (806), pp. eadu4564. Date of Electronic Publication: 2025 Jul 09.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 40632837
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Antitrypanosomal quinazolines targeting lysyl-tRNA synthetase show partial efficacy in a mouse model of acute Chagas disease.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Tulloch+LB%22">Tulloch LB</searchLink>; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.<br /><searchLink fieldCode="AU" term="%22Tawell+H%22">Tawell H</searchLink>; Department of Chemistry, Loughborough University, Loughborough LE11 3TU, UK.<br /><searchLink fieldCode="AU" term="%22Taylor+AE%22">Taylor AE</searchLink>; Leicester School of Allied Health Sciences, De Montfort University, The Gateway, Leicester LE1 9BH, UK.<br /><searchLink fieldCode="AU" term="%22Lima+ML%22">Lima ML</searchLink>; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.<br /><searchLink fieldCode="AU" term="%22Dawson+A%22">Dawson A</searchLink>; Drug Discovery Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.<br /><searchLink fieldCode="AU" term="%22Carvalho+S%22">Carvalho S</searchLink>; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.<br /><searchLink fieldCode="AU" term="%22Wall+RJ%22">Wall RJ</searchLink>; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.<br /><searchLink fieldCode="AU" term="%22Corpas-Lopez+V%22">Corpas-Lopez V</searchLink>; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.<br /><searchLink fieldCode="AU" term="%22Dey+G%22">Dey G</searchLink>; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.<br /><searchLink fieldCode="AU" term="%22Duggan+J%22">Duggan J</searchLink>; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.<br /><searchLink fieldCode="AU" term="%22Magalhaes+LG%22">Magalhaes LG</searchLink>; Drug Discovery Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.<br /><searchLink fieldCode="AU" term="%22Torrie+LS%22">Torrie LS</searchLink>; Drug Discovery Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.<br /><searchLink fieldCode="AU" term="%22Frame+L%22">Frame L</searchLink>; Drug Discovery Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.<br /><searchLink fieldCode="AU" term="%22Robinson+D%22">Robinson D</searchLink>; Drug Discovery Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.<br /><searchLink fieldCode="AU" term="%22Patterson+S%22">Patterson S</searchLink>; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.<br /><searchLink fieldCode="AU" term="%22Tinti+M%22">Tinti M</searchLink>; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.<br /><searchLink fieldCode="AU" term="%22Weaver+GW%22">Weaver GW</searchLink>; Department of Chemistry, Loughborough University, Loughborough LE11 3TU, UK.<br /><searchLink fieldCode="AU" term="%22Robinson+WJ%22">Robinson WJ</searchLink>; Leicester School of Allied Health Sciences, De Montfort University, The Gateway, Leicester LE1 9BH, UK.<br /><searchLink fieldCode="AU" term="%22Cal+M%22">Cal M</searchLink>; Swiss Tropical and Public Health Institute, 4123 Allschwil, Switzerland.; University of Basel, 4003 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Kaiser+M%22">Kaiser M</searchLink>; Swiss Tropical and Public Health Institute, 4123 Allschwil, Switzerland.; University of Basel, 4003 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Mäser+P%22">Mäser P</searchLink>; Swiss Tropical and Public Health Institute, 4123 Allschwil, Switzerland.; University of Basel, 4003 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Sjö+P%22">Sjö P</searchLink>; Drugs for Neglected Diseases Initiative (DNDi), 1202 Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Perry+B%22">Perry B</searchLink>; Drugs for Neglected Diseases Initiative (DNDi), 1202 Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Kelly+JM%22">Kelly JM</searchLink>; London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.<br /><searchLink fieldCode="AU" term="%22Francisco+AF%22">Francisco AF</searchLink>; London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.<br /><searchLink fieldCode="AU" term="%22Bhambra+AS%22">Bhambra AS</searchLink>; Leicester School of Allied Health Sciences, De Montfort University, The Gateway, Leicester LE1 9BH, UK.<br /><searchLink fieldCode="AU" term="%22Wyllie+S%22">Wyllie S</searchLink>; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101505086%22">Science translational medicine</searchLink> [Sci Transl Med] 2025 Jul 09; Vol. 17 (806), pp. eadu4564. <i>Date of Electronic Publication: </i>2025 Jul 09.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+the+Advancement+of+Science%22">American Association for the Advancement of Science </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101505086 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1946-6242 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2219466234%22">19466234 </searchLink><i>NLM ISO Abbreviation: </i>Sci Transl Med <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=40632837
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1126/scitranslmed.adu4564
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: eadu4564
    Titles:
      – TitleFull: Antitrypanosomal quinazolines targeting lysyl-tRNA synthetase show partial efficacy in a mouse model of acute Chagas disease.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Tulloch LB
      – PersonEntity:
          Name:
            NameFull: Tawell H
      – PersonEntity:
          Name:
            NameFull: Taylor AE
      – PersonEntity:
          Name:
            NameFull: Lima ML
      – PersonEntity:
          Name:
            NameFull: Dawson A
      – PersonEntity:
          Name:
            NameFull: Carvalho S
      – PersonEntity:
          Name:
            NameFull: Wall RJ
      – PersonEntity:
          Name:
            NameFull: Corpas-Lopez V
      – PersonEntity:
          Name:
            NameFull: Dey G
      – PersonEntity:
          Name:
            NameFull: Duggan J
      – PersonEntity:
          Name:
            NameFull: Magalhaes LG
      – PersonEntity:
          Name:
            NameFull: Torrie LS
      – PersonEntity:
          Name:
            NameFull: Frame L
      – PersonEntity:
          Name:
            NameFull: Robinson D
      – PersonEntity:
          Name:
            NameFull: Patterson S
      – PersonEntity:
          Name:
            NameFull: Tinti M
      – PersonEntity:
          Name:
            NameFull: Weaver GW
      – PersonEntity:
          Name:
            NameFull: Robinson WJ
      – PersonEntity:
          Name:
            NameFull: Cal M
      – PersonEntity:
          Name:
            NameFull: Kaiser M
      – PersonEntity:
          Name:
            NameFull: Mäser P
      – PersonEntity:
          Name:
            NameFull: Sjö P
      – PersonEntity:
          Name:
            NameFull: Perry B
      – PersonEntity:
          Name:
            NameFull: Kelly JM
      – PersonEntity:
          Name:
            NameFull: Francisco AF
      – PersonEntity:
          Name:
            NameFull: Bhambra AS
      – PersonEntity:
          Name:
            NameFull: Wyllie S
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 09
              M: 07
              Text: 2025 Jul 09
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 1946-6242
          Numbering:
            – Type: volume
              Value: 17
            – Type: issue
              Value: 806
          Titles:
            – TitleFull: Science translational medicine
              Type: main
ResultId 1