Loss of FCoV-23 spike domain 0 enhances fusogenicity and entry kinetics.

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Title: Loss of FCoV-23 spike domain 0 enhances fusogenicity and entry kinetics.
Authors: Tortorici MA; Department of Biochemistry, University of Washington, Seattle, WA, USA., Choi A; Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA., Gibson CA; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Howard Hughes Medical Institute, Seattle, WA, USA., Lee J; Department of Biochemistry, University of Washington, Seattle, WA, USA., Brown JT; Department of Biochemistry, University of Washington, Seattle, WA, USA., Stewart C; Department of Biochemistry, University of Washington, Seattle, WA, USA., Joshi A; Department of Biochemistry, University of Washington, Seattle, WA, USA., Harari S; Basic Sciences Division and Computational Biology Program, Fred Hutchinson Cancer Center, Seattle, WA, USA., Willoughby I; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Treichel C; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Leaf EM; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Bloom JD; Howard Hughes Medical Institute, Seattle, WA, USA.; Basic Sciences Division and Computational Biology Program, Fred Hutchinson Cancer Center, Seattle, WA, USA., King NP; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Tait-Burkard C; The Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK., Whittaker GR; Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.; Public and Ecosystem Health, Cornell University, Ithaca, NY, USA.; Feline Health Center, Cornell University, Ithaca, NY, USA., Veesler D; Department of Biochemistry, University of Washington, Seattle, WA, USA. dveesler@uw.edu.; Howard Hughes Medical Institute, Seattle, WA, USA. dveesler@uw.edu.
Source: Nature [Nature] 2025 Sep; Vol. 645 (8079), pp. 235-243. Date of Electronic Publication: 2025 Jul 09.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-4687
DOI:10.1038/s41586-025-09155-z