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Loss of FCoV-23 spike domain 0 enhances fusogenicity and entry kinetics.

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Title: Loss of FCoV-23 spike domain 0 enhances fusogenicity and entry kinetics.
Authors: Tortorici MA; Department of Biochemistry, University of Washington, Seattle, WA, USA., Choi A; Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA., Gibson CA; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Howard Hughes Medical Institute, Seattle, WA, USA., Lee J; Department of Biochemistry, University of Washington, Seattle, WA, USA., Brown JT; Department of Biochemistry, University of Washington, Seattle, WA, USA., Stewart C; Department of Biochemistry, University of Washington, Seattle, WA, USA., Joshi A; Department of Biochemistry, University of Washington, Seattle, WA, USA., Harari S; Basic Sciences Division and Computational Biology Program, Fred Hutchinson Cancer Center, Seattle, WA, USA., Willoughby I; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Treichel C; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Leaf EM; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Bloom JD; Howard Hughes Medical Institute, Seattle, WA, USA.; Basic Sciences Division and Computational Biology Program, Fred Hutchinson Cancer Center, Seattle, WA, USA., King NP; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Tait-Burkard C; The Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK., Whittaker GR; Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.; Public and Ecosystem Health, Cornell University, Ithaca, NY, USA.; Feline Health Center, Cornell University, Ithaca, NY, USA., Veesler D; Department of Biochemistry, University of Washington, Seattle, WA, USA. dveesler@uw.edu.; Howard Hughes Medical Institute, Seattle, WA, USA. dveesler@uw.edu.
Source: Nature [Nature] 2025 Sep; Vol. 645 (8079), pp. 235-243. Date of Electronic Publication: 2025 Jul 09.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
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  Data: Loss of FCoV-23 spike domain 0 enhances fusogenicity and entry kinetics.
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  Data: <searchLink fieldCode="AU" term="%22Tortorici+MA%22">Tortorici MA</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Choi+A%22">Choi A</searchLink>; Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.<br /><searchLink fieldCode="AU" term="%22Gibson+CA%22">Gibson CA</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Howard Hughes Medical Institute, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Lee+J%22">Lee J</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Brown+JT%22">Brown JT</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Stewart+C%22">Stewart C</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Joshi+A%22">Joshi A</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Harari+S%22">Harari S</searchLink>; Basic Sciences Division and Computational Biology Program, Fred Hutchinson Cancer Center, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Willoughby+I%22">Willoughby I</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Treichel+C%22">Treichel C</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Leaf+EM%22">Leaf EM</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Bloom+JD%22">Bloom JD</searchLink>; Howard Hughes Medical Institute, Seattle, WA, USA.; Basic Sciences Division and Computational Biology Program, Fred Hutchinson Cancer Center, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22King+NP%22">King NP</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Tait-Burkard+C%22">Tait-Burkard C</searchLink>; The Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Whittaker+GR%22">Whittaker GR</searchLink>; Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.; Public and Ecosystem Health, Cornell University, Ithaca, NY, USA.; Feline Health Center, Cornell University, Ithaca, NY, USA.<br /><searchLink fieldCode="AU" term="%22Veesler+D%22">Veesler D</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA. dveesler@uw.edu.; Howard Hughes Medical Institute, Seattle, WA, USA. dveesler@uw.edu.
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