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Invasive disease-free and overall survival after (neo)adjuvant chemotherapy in postmenopausal patients with hormone receptor-positive, HER2-negative early breast cancer treated with upfront letrozole: Experiences from the phase IV PreFace trial.

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Title: Invasive disease-free and overall survival after (neo)adjuvant chemotherapy in postmenopausal patients with hormone receptor-positive, HER2-negative early breast cancer treated with upfront letrozole: Experiences from the phase IV PreFace trial.
Authors: Beierlein M; Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Häberle L; Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.; Biostatistics Unit, Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany., Nabieva N; Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Maass N; Department of Gynecology and Obstetrics, University Hospital of Schleswig-Holstein, Campus Kiel, Kiel, Germany., Aktas B; Department of Gynecology, University Hospital Leipzig, Leipzig, Germany., Kümmel S; Breast Unit, Kliniken Essen-Mitte, Essen, Germany.; Charité-Universitätsmedizin Berlin, Department of Gynecology with Breast Center, Berlin, Germany., Thomssen C; Department of Gynaecology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany., Wolf C; Medical Center Ulm, Ulm, Germany., Kolberg HC; Department of Gynecology and Obstetrics, Marienhospital Bottrop, Bottrop, Germany., Brucker C; Department of Gynecology and Obstetrics, University Hospital, Paracelsus Medical University, Nuremberg, Germany., Janni W; Department of Gynecology and Obstetrics, Ulm University Hospital, Ulm, Germany., Dall P; Department of Gynecology, Lüneburg Clinic, Lüneburg, Germany., Schneeweiss A; Division of Gynecologic Oncology, National Center for Tumor Diseases, University Hospital and German Cancer Research Center, Heidelberg, Germany., Marme F; Department of Gynecology and Obstetrics, University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Sütterlin MW; Department of Gynecology and Obstetrics, University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Ruebner M; Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Theuser AK; Institut für Frauengesundheit GmbH, Erlangen, Germany., Hofmann NM; Institut für Frauengesundheit GmbH, Erlangen, Germany., Böhm S; Institut für Frauengesundheit GmbH, Erlangen, Germany., Almstedt K; Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.; Department of Obstetrics and Gynecology, University Medical Center Mainz, Johannes Gutenberg University, Mainz, Germany., Kellner S; Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Gass P; Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.; Klinikum Chemnitz gGmbH, Medizincampus Chemnitz der Technischen Universität Dresden, Dresden, Germany., Lück HJ; Gynäkologisch-Onkologische Praxis Hannover, Hannover, Germany., Hein A; Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.; Department of Gynecology and Obstetrics, Klinikum Esslingen, Esslingen, Germany., Schmatloch S; Elisabeth Krankenhaus Kassel, Kassel, Germany., Kalder M; Department of Gynecology and Obstetrics, University Hospital Gießen and Marburg, Marburg, Germany., Uleer C; Gyn.-onkologische Gemeinschaftspraxis Hildesheim, Hildesheim, Germany., Juhasz-Böss I; Department of Obstetrics and Gynecology, Freiburg University Hospital, Freiburg, Germany., Hanf V; Frauenklinik, Klinikum Fürth, Fürth, Germany., Jackisch C; Frauenklinik Sana Klinikum, Offenbach, Germany., Müller V; Department of Gynecology, Hamburg-Eppendorf University Medical Center, Hamburg, Germany., Rack B; Department of Gynecology and Obstetrics, Ulm University Hospital, Ulm, Germany., Belleville E; ClinSol GmbH & Co. KG, Würzburg, Germany., Wallwiener D; Department of Obstetrics and Gynecology, University of Tuebingen, Tuebingen, Germany., Rody A; Department of Gynecology and Obstetrics, University Hospital Schleswig-Holsteinm, Campus Lübeck, Lübeck, Germany., Rauh C; Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.; Department of Gynecology, University Hospital Inselspital Bern, Bern, Switzerland., Bayer CM; Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.; Kreisklinik Ebersberg, Ebersberg, Germany., Uhrig S; Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Huebner H; Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Goossens C; Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Brucker SY; Department of Obstetrics and Gynecology, University of Tuebingen, Tuebingen, Germany., Hack CC; Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Fehm TN; Department of Gynecology and Obstetrics, University Hospital Düsseldorf, Düsseldorf, Germany.; Centrum für Integrierte Onkologie Aachen Bonn Köln Düsseldorf, Düsseldorf, Germany., Fasching PA; Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Source: International journal of cancer [Int J Cancer] 2025 Dec 01; Vol. 157 (11), pp. 2363-2373. Date of Electronic Publication: 2025 Jul 11.
Publication Type: Journal Article; Clinical Trial, Phase IV
Journal Info: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 0042124 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0215 (Electronic) Linking ISSN: 00207136 NLM ISO Abbreviation: Int J Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Invasive disease-free and overall survival after (neo)adjuvant chemotherapy in postmenopausal patients with hormone receptor-positive, HER2-negative early breast cancer treated with upfront letrozole: Experiences from the phase IV PreFace trial.
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  Data: <searchLink fieldCode="AU" term="%22Beierlein+M%22">Beierlein M</searchLink>; Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Häberle+L%22">Häberle L</searchLink>; Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.; Biostatistics Unit, Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Nabieva+N%22">Nabieva N</searchLink>; Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Maass+N%22">Maass N</searchLink>; Department of Gynecology and Obstetrics, University Hospital of Schleswig-Holstein, Campus Kiel, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Aktas+B%22">Aktas B</searchLink>; Department of Gynecology, University Hospital Leipzig, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Kümmel+S%22">Kümmel S</searchLink>; Breast Unit, Kliniken Essen-Mitte, Essen, Germany.; Charité-Universitätsmedizin Berlin, Department of Gynecology with Breast Center, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Thomssen+C%22">Thomssen C</searchLink>; Department of Gynaecology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany.<br /><searchLink fieldCode="AU" term="%22Wolf+C%22">Wolf C</searchLink>; Medical Center Ulm, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Kolberg+HC%22">Kolberg HC</searchLink>; Department of Gynecology and Obstetrics, Marienhospital Bottrop, Bottrop, Germany.<br /><searchLink fieldCode="AU" term="%22Brucker+C%22">Brucker C</searchLink>; 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