KRASG12D selective VHL-PROTAC with sparing KRASWT and other KRAS mutants.

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Title: KRASG12D selective VHL-PROTAC with sparing KRASWT and other KRAS mutants.
Authors: Jeon E; Department of Medical Science, Graduate School of Medical Science, Brain Korea 21 FOUR Project, Yonsei University College of Medicine, Seoul, Republic of Korea; Department of Biomedical Sciences, Yonsei University College of Medicine, Seoul, Republic of Korea., Kim C; Department of Medical Science, Graduate School of Medical Science, Brain Korea 21 FOUR Project, Yonsei University College of Medicine, Seoul, Republic of Korea; Department of Biomedical Sciences, Yonsei University College of Medicine, Seoul, Republic of Korea., Ko M; Department of Medical Science, Graduate School of Medical Science, Brain Korea 21 FOUR Project, Yonsei University College of Medicine, Seoul, Republic of Korea; Department of Biomedical Sciences, Yonsei University College of Medicine, Seoul, Republic of Korea., Kim TK; Department of Internal Medicine, Graduate School of Medical Science, Brain Korea 21 FOUR Project, Yonsei University College of Medicine, Seoul, Republic of Korea., Bae J; Department of Medical Science, Graduate School of Medical Science, Brain Korea 21 FOUR Project, Yonsei University College of Medicine, Seoul, Republic of Korea; Department of Biomedical Sciences, Yonsei University College of Medicine, Seoul, Republic of Korea., Oh JW; Department of Applied Chemistry, Institute of Natural Science, Kyung Hee University, Yongin, Republic of Korea; Department of Biomedical Science and Technology, Kyung Hee Medical Science Research Institute, Kyung Hee University, Seoul, Republic of Korea., Kim KP; Department of Applied Chemistry, Institute of Natural Science, Kyung Hee University, Yongin, Republic of Korea; Department of Biomedical Science and Technology, Kyung Hee Medical Science Research Institute, Kyung Hee University, Seoul, Republic of Korea., Kim HS; Department of Internal Medicine, Graduate School of Medical Science, Brain Korea 21 FOUR Project, Yonsei University College of Medicine, Seoul, Republic of Korea; Yonsei Cancer Center, Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea., Sim T; Department of Medical Science, Graduate School of Medical Science, Brain Korea 21 FOUR Project, Yonsei University College of Medicine, Seoul, Republic of Korea; Department of Biomedical Sciences, Yonsei University College of Medicine, Seoul, Republic of Korea; Graduate School of Clinical Drug Discovery & Development, Yonsei University College of Medicine, Seoul, Republic of Korea; Clinical Candidate Discovery & Development Institute, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address: TBSIM@yuhs.ac.
Source: European journal of medicinal chemistry [Eur J Med Chem] 2025 Nov 05; Vol. 297, pp. 117928. Date of Electronic Publication: 2025 Jul 05.
Publication Type: Journal Article
Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1768-3254
DOI:10.1016/j.ejmech.2025.117928