Integrated genomics with refined cell-of-origin subtyping distinguishes subtype-specific mechanisms of treatment resistance and relapse in diffuse large B-cell lymphoma.

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Title: Integrated genomics with refined cell-of-origin subtyping distinguishes subtype-specific mechanisms of treatment resistance and relapse in diffuse large B-cell lymphoma.
Authors: Walker JS; Division of Hematology, Mayo Clinic, Rochester, MN, USA., Wenzl K; Division of Hematology, Mayo Clinic, Rochester, MN, USA.; Informatics and Predictive Sciences, Bristol Myers Squibb, Summit, NJ, USA., Novak JP; Division of Hematology, Mayo Clinic, Rochester, MN, USA., Stokes ME; Informatics and Predictive Sciences, Bristol Myers Squibb, Summit, NJ, USA., Hopper MA; Division of Hematology, Mayo Clinic, Rochester, MN, USA., Dropik AR; Division of Hematology, Mayo Clinic, Rochester, MN, USA., Siminski MS; Division of Hematology, Mayo Clinic, Rochester, MN, USA., Bock AM; Division of Hematology, Mayo Clinic, Rochester, MN, USA.; Division of Hematology and Hematologic Malignancies, Huntsman Cancer Institute/University of Utah, Salt Lake City, UT, USA., Sarangi V; Department of Quantitative Health Sciences Research, Mayo Clinic, Rochester, MN, USA., Ortiz M; Informatics and Predictive Sciences, Celgene Institute for Translational Research Europe (CITRE), Seville, Spain., Stong N; Informatics and Predictive Sciences, Bristol Myers Squibb, Summit, NJ, USA., Huang CC; Translational Medicine Hematology, Bristol Myers Squibb, Summit, NJ, USA., Maurer MJ; Division of Hematology, Mayo Clinic, Rochester, MN, USA.; Department of Quantitative Health Sciences Research, Mayo Clinic, Rochester, MN, USA., Link BK; Division of Hematology, University of Iowa, Iowa City, IA, USA., Ansell SM; Division of Hematology, Mayo Clinic, Rochester, MN, USA., Habermann TM; Division of Hematology, Mayo Clinic, Rochester, MN, USA., Witzig TE; Division of Hematology, Mayo Clinic, Rochester, MN, USA., King RL; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA., Nowakowski G; Division of Hematology, Mayo Clinic, Rochester, MN, USA., Cerhan JR; Department of Quantitative Health Sciences Research, Mayo Clinic, Rochester, MN, USA., Gandhi AK; Translational Medicine Hematology, Bristol Myers Squibb, Summit, NJ, USA., Novak AJ; Division of Hematology, Mayo Clinic, Rochester, MN, USA. Novak.Anne@mayo.edu.
Source: Blood cancer journal [Blood Cancer J] 2025 Jul 12; Vol. 15 (1), pp. 120. Date of Electronic Publication: 2025 Jul 12.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101568469 Publication Model: Electronic Cited Medium: Internet ISSN: 2044-5385 (Electronic) Linking ISSN: 20445385 NLM ISO Abbreviation: Blood Cancer J Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2044-5385
DOI:10.1038/s41408-025-01326-5