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Selective Alanine Transporter Utilization Is a Therapeutic Vulnerability in ARID1A-Mutant Ovarian Cancer.

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Title: Selective Alanine Transporter Utilization Is a Therapeutic Vulnerability in ARID1A-Mutant Ovarian Cancer.
Authors: Nie H; Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas., Liao L; Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas., Zielinski RJ; Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas., Gomez JA; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas., Basi AV; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas., Seeley EH; Department of Chemistry, The University of Texas at Austin, Austin, Texas., Tan L; Metabolomics Core Facility, Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Bilecz AJ; Department of Obstetrics and Gynecology/Section of Gynecologic Oncology, University of Chicago, Chicago, Illinois., Zhou W; Immunology, Microenvironment & Metastasis Program, The Wistar Institute, Philadelphia, Pennsylvania., Liu H; Immunology, Microenvironment & Metastasis Program, The Wistar Institute, Philadelphia, Pennsylvania., Wang C; Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas., Wu S; Immunology, Microenvironment & Metastasis Program, The Wistar Institute, Philadelphia, Pennsylvania., Qi Y; Metabolomics Core Facility, Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Miyamoto T; Immunology, Microenvironment & Metastasis Program, The Wistar Institute, Philadelphia, Pennsylvania., Severi F; Immunology, Microenvironment & Metastasis Program, The Wistar Institute, Philadelphia, Pennsylvania., Goldman AR; Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, Pennsylvania., Gu S; Department of Hematopoietic Biology and Malignancy, The University of Texas MD Anderson Cancer Center, Houston, Texas., Sood AK; Department of Gynecological Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Jazaeri AA; Department of Gynecological Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Drapkin R; Department of Obstetrics and Gynecology, Penn Ovarian Cancer Research Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Claiborne DT; Immunology, Microenvironment & Metastasis Program, The Wistar Institute, Philadelphia, Pennsylvania., Zhang N; Immunology, Microenvironment & Metastasis Program, The Wistar Institute, Philadelphia, Pennsylvania., Lorenzi PL; Metabolomics Core Facility, Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Burks JK; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas., Lengyel E; Department of Obstetrics and Gynecology/Section of Gynecologic Oncology, University of Chicago, Chicago, Illinois., Gottlieb E; Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Zhang R; Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Source: Cancer research [Cancer Res] 2025 Sep 15; Vol. 85 (18), pp. 3471-3489.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Selective Alanine Transporter Utilization Is a Therapeutic Vulnerability in ARID1A-Mutant Ovarian Cancer.
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  Data: <searchLink fieldCode="AU" term="%22Nie+H%22">Nie H</searchLink>; Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Liao+L%22">Liao L</searchLink>; Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Zielinski+RJ%22">Zielinski RJ</searchLink>; Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Gomez+JA%22">Gomez JA</searchLink>; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Basi+AV%22">Basi AV</searchLink>; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Seeley+EH%22">Seeley EH</searchLink>; Department of Chemistry, The University of Texas at Austin, Austin, Texas.<br /><searchLink fieldCode="AU" term="%22Tan+L%22">Tan L</searchLink>; Metabolomics Core Facility, Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Bilecz+AJ%22">Bilecz AJ</searchLink>; Department of Obstetrics and Gynecology/Section of Gynecologic Oncology, University of Chicago, Chicago, Illinois.<br /><searchLink fieldCode="AU" term="%22Zhou+W%22">Zhou W</searchLink>; Immunology, Microenvironment & Metastasis Program, The Wistar Institute, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Liu+H%22">Liu H</searchLink>; Immunology, Microenvironment & Metastasis Program, The Wistar Institute, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Wang+C%22">Wang C</searchLink>; Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Wu+S%22">Wu S</searchLink>; Immunology, Microenvironment & Metastasis Program, The Wistar Institute, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Qi+Y%22">Qi Y</searchLink>; Metabolomics Core Facility, Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Miyamoto+T%22">Miyamoto T</searchLink>; Immunology, Microenvironment & Metastasis Program, The Wistar Institute, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Severi+F%22">Severi F</searchLink>; Immunology, Microenvironment & Metastasis Program, The Wistar Institute, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Goldman+AR%22">Goldman AR</searchLink>; Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Gu+S%22">Gu S</searchLink>; Department of Hematopoietic Biology and Malignancy, The University of Texas MD Anderson Cancer Center, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Sood+AK%22">Sood AK</searchLink>; Department of Gynecological Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Jazaeri+AA%22">Jazaeri AA</searchLink>; Department of Gynecological Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Drapkin+R%22">Drapkin R</searchLink>; Department of Obstetrics and Gynecology, Penn Ovarian Cancer Research Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Claiborne+DT%22">Claiborne DT</searchLink>; Immunology, Microenvironment & Metastasis Program, The Wistar Institute, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Zhang+N%22">Zhang N</searchLink>; Immunology, Microenvironment & Metastasis Program, The Wistar Institute, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Lorenzi+PL%22">Lorenzi PL</searchLink>; Metabolomics Core Facility, Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Burks+JK%22">Burks JK</searchLink>; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Lengyel+E%22">Lengyel E</searchLink>; Department of Obstetrics and Gynecology/Section of Gynecologic Oncology, University of Chicago, Chicago, Illinois.<br /><searchLink fieldCode="AU" term="%22Gottlieb+E%22">Gottlieb E</searchLink>; Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Zhang+R%22">Zhang R</searchLink>; Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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