12/15-lipoxygenase mediates disturbed flow-induced endothelial dysfunction and atherosclerosis.

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Title: 12/15-lipoxygenase mediates disturbed flow-induced endothelial dysfunction and atherosclerosis.
Authors: Chen JW; Department of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao-Tong University School of Medicine, 197 Ruijin Er Rd, Shanghai, 200025, China.; Institute of Cardiovascular Diseases, Shanghai Jiao-Tong University School of Medicine, Shanghai, 200025, China., Chen SL; Shanghai Key Laboratory of Biliary Tract Disease Research, Department of General Surgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China., Wu XR; Department of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao-Tong University School of Medicine, 197 Ruijin Er Rd, Shanghai, 200025, China.; Institute of Cardiovascular Diseases, Shanghai Jiao-Tong University School of Medicine, Shanghai, 200025, China., Shu XY; Department of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao-Tong University School of Medicine, 197 Ruijin Er Rd, Shanghai, 200025, China.; Institute of Cardiovascular Diseases, Shanghai Jiao-Tong University School of Medicine, Shanghai, 200025, China., Tang SY; Department of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao-Tong University School of Medicine, 197 Ruijin Er Rd, Shanghai, 200025, China.; Institute of Cardiovascular Diseases, Shanghai Jiao-Tong University School of Medicine, Shanghai, 200025, China., Yuan H; Department of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao-Tong University School of Medicine, 197 Ruijin Er Rd, Shanghai, 200025, China.; Institute of Cardiovascular Diseases, Shanghai Jiao-Tong University School of Medicine, Shanghai, 200025, China., Li YR; Department of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao-Tong University School of Medicine, 197 Ruijin Er Rd, Shanghai, 200025, China.; Institute of Cardiovascular Diseases, Shanghai Jiao-Tong University School of Medicine, Shanghai, 200025, China., Quan JW; Department of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao-Tong University School of Medicine, 197 Ruijin Er Rd, Shanghai, 200025, China.; Institute of Cardiovascular Diseases, Shanghai Jiao-Tong University School of Medicine, Shanghai, 200025, China., Feng S; Department of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao-Tong University School of Medicine, 197 Ruijin Er Rd, Shanghai, 200025, China., Zhang RY; Department of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao-Tong University School of Medicine, 197 Ruijin Er Rd, Shanghai, 200025, China.; Institute of Cardiovascular Diseases, Shanghai Jiao-Tong University School of Medicine, Shanghai, 200025, China., Yang CD; Department of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao-Tong University School of Medicine, 197 Ruijin Er Rd, Shanghai, 200025, China. yangcd@shsmu.edu.cn.; Institute of Cardiovascular Diseases, Shanghai Jiao-Tong University School of Medicine, Shanghai, 200025, China. yangcd@shsmu.edu.cn., Lu L; Department of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao-Tong University School of Medicine, 197 Ruijin Er Rd, Shanghai, 200025, China. rjlulin1965@163.com.; Institute of Cardiovascular Diseases, Shanghai Jiao-Tong University School of Medicine, Shanghai, 200025, China. rjlulin1965@163.com., Wang XQ; Department of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao-Tong University School of Medicine, 197 Ruijin Er Rd, Shanghai, 200025, China. wangxq@shsmu.edu.cn.; Institute of Cardiovascular Diseases, Shanghai Jiao-Tong University School of Medicine, Shanghai, 200025, China. wangxq@shsmu.edu.cn.
Source: Molecular medicine (Cambridge, Mass.) [Mol Med] 2025 Jul 15; Vol. 31 (1), pp. 257. Date of Electronic Publication: 2025 Jul 15.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 9501023 Publication Model: Electronic Cited Medium: Internet ISSN: 1528-3658 (Electronic) Linking ISSN: 10761551 NLM ISO Abbreviation: Mol Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1528-3658
DOI:10.1186/s10020-025-01297-0