Accumulation of LRRK2-associated phospho-Rab12 degenerative lysosomes in tauopathies.

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Title: Accumulation of LRRK2-associated phospho-Rab12 degenerative lysosomes in tauopathies.
Authors: Buck SA; Department of Neurology, Duke University School of Medicine, Durham, NC, 27710, USA.; Department of Pathology, Duke University School of Medicine, Durham, NC, 27710, USA.; Duke Center for Neurodegeneration and Neurotherapeutics, Duke University, Durham, NC, 27710, USA., Malankhanova T; Duke Center for Neurodegeneration and Neurotherapeutics, Duke University, Durham, NC, 27710, USA.; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, 27710, USA., Ma EB; Department of Neurology, Duke University School of Medicine, Durham, NC, 27710, USA.; Department of Pathology, Duke University School of Medicine, Durham, NC, 27710, USA.; Duke Center for Neurodegeneration and Neurotherapeutics, Duke University, Durham, NC, 27710, USA., Yim S; Department of Neurology, Duke University School of Medicine, Durham, NC, 27710, USA.; Department of Pathology, Duke University School of Medicine, Durham, NC, 27710, USA.; Duke Center for Neurodegeneration and Neurotherapeutics, Duke University, Durham, NC, 27710, USA., Pratt HW; Department of Neurology, Duke University School of Medicine, Durham, NC, 27710, USA.; Department of Pathology, Duke University School of Medicine, Durham, NC, 27710, USA.; Duke Center for Neurodegeneration and Neurotherapeutics, Duke University, Durham, NC, 27710, USA., Ervin J; Department of Neurology, Duke University School of Medicine, Durham, NC, 27710, USA.; Department of Pathology, Duke University School of Medicine, Durham, NC, 27710, USA.; Duke/UNC Alzheimer's Disease Research Center, Durham, NC, 27710, USA., Wang SJ; Department of Neurology, Duke University School of Medicine, Durham, NC, 27710, USA.; Department of Pathology, Duke University School of Medicine, Durham, NC, 27710, USA.; Duke/UNC Alzheimer's Disease Research Center, Durham, NC, 27710, USA., Cohen TJ; Department of Neurology, University of North Carolina, Chapel Hill, NC, 27599, USA.; Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC, 27599, USA.; Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC, 27599, USA.; UNC Neuroscience Center, University of North Carolina, Chapel Hill, NC, 27599, USA., West AB; Department of Neurology, Duke University School of Medicine, Durham, NC, 27710, USA.; Duke Center for Neurodegeneration and Neurotherapeutics, Duke University, Durham, NC, 27710, USA.; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, 27710, USA., Sanders LH; Department of Neurology, Duke University School of Medicine, Durham, NC, 27710, USA.; Department of Pathology, Duke University School of Medicine, Durham, NC, 27710, USA.; Duke Center for Neurodegeneration and Neurotherapeutics, Duke University, Durham, NC, 27710, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Jun 09. Date of Electronic Publication: 2025 Jun 09.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2692-8205
DOI:10.1101/2025.06.06.658328