Chondroitin Sulfate A-Selenium Nanoparticles Activate Autophagy Through the AMPK-mTOR Pathway to Alleviate Oxidative Stress and Mitochondrial Dysfunction to Repair Kashin-Beck Disease Chondrocytes.

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Title: Chondroitin Sulfate A-Selenium Nanoparticles Activate Autophagy Through the AMPK-mTOR Pathway to Alleviate Oxidative Stress and Mitochondrial Dysfunction to Repair Kashin-Beck Disease Chondrocytes.
Authors: Deng H; Department of Occupational and Environmental Health, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China.; Health Science Center, Global Health Institute, Xi'an Jiaotong University, Xi'an, Shaanxi, 712000, China.; Key Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province, Xi'an, 710049, Shaanxi, China.; Key Laboratory of Environment and Genes Related to Diseases, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China., Qiao L; Department of Occupational and Environmental Health, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China.; Health Science Center, Global Health Institute, Xi'an Jiaotong University, Xi'an, Shaanxi, 712000, China.; Key Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province, Xi'an, 710049, Shaanxi, China.; Key Laboratory of Environment and Genes Related to Diseases, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China., Jiang Y; Department of Nutrition, Western Theater Command Air Force Hospital of PLA, Chengdu, 610083, Sichuan, China., Amhare AF; Department of Occupational and Environmental Health, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China.; Health Science Center, Global Health Institute, Xi'an Jiaotong University, Xi'an, Shaanxi, 712000, China.; Key Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province, Xi'an, 710049, Shaanxi, China.; Key Laboratory of Environment and Genes Related to Diseases, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China., Han J; Department of Occupational and Environmental Health, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China. bbbishop@126.com.; Health Science Center, Global Health Institute, Xi'an Jiaotong University, Xi'an, Shaanxi, 712000, China. bbbishop@126.com.; Key Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province, Xi'an, 710049, Shaanxi, China. bbbishop@126.com.; Key Laboratory of Environment and Genes Related to Diseases, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China. bbbishop@126.com.
Source: Biological trace element research [Biol Trace Elem Res] 2026 Feb; Vol. 204 (2), pp. 1099-1112. Date of Electronic Publication: 2025 Jul 15.
Publication Type: Journal Article
Journal Info: Publisher: Humana Press Country of Publication: United States NLM ID: 7911509 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-0720 (Electronic) Linking ISSN: 01634984 NLM ISO Abbreviation: Biol Trace Elem Res Subsets: MEDLINE
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  Data: Chondroitin Sulfate A-Selenium Nanoparticles Activate Autophagy Through the AMPK-mTOR Pathway to Alleviate Oxidative Stress and Mitochondrial Dysfunction to Repair Kashin-Beck Disease Chondrocytes.
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              Text: 2026 Feb
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