TRPML2 channel modulation by PI(3,5)P₂ and small-molecule agonists controls endosomal vesicle dynamics.

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Title: TRPML2 channel modulation by PI(3,5)P₂ and small-molecule agonists controls endosomal vesicle dynamics.
Authors: Gu ZQ; Laboratory of Host-Microbe Interactions and Cell Dynamics, Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Taoyuan, Taiwan; Institute of Microbiology and Immunology, College of Life Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan., Wang HT; Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan., Li Y; Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians-Universität, Munich, Germany., Krogsaeter E; J. David Gladstone Institutes, San Francisco, CA, USA., Lin AC; Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan., Lin J; Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan., Liu YS; Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan., Lin WS; Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan., Burton W; Department of Pharmacology; University of Oxford; Oxford, UK., Liu ML; Institute of Microbiology and Immunology, College of Life Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan., Feldmann C; Institute of Cardiovascular Physiology and Pathophysiology, Vegetative Physiology, Ludwig-Maximilians-Universität, Munich, Germany., Tang R; Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-Universität, Munich, Germany., Po CW; Institute of Anatomy and Cell Biology, National Yang-Ming Chiao Tung University, Taipei, Taiwan., Hou PS; Institute of Anatomy and Cell Biology, National Yang-Ming Chiao Tung University, Taipei, Taiwan., Lin NY; Graduate Institute of Anatomy and Cell Biology, National Taiwan University College of Medicine, Taipei, Taiwan., Lin JY; Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan; Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan., Chao TL; Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan; Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians-Universität, Munich, Germany; Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan., Chang SY; Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan; Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan., Yang Z; Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians-Universität, Munich, Germany., Keller M; Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians-Universität, Munich, Germany., Leser C; Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians-Universität, Munich, Germany., Fenske S; Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians-Universität, Munich, Germany., Bracher F; Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians-Universität, Munich, Germany., Wahl-Schott C; Institute of Cardiovascular Physiology and Pathophysiology, Vegetative Physiology, Ludwig-Maximilians-Universität, Munich, Germany., Galione A; Department of Pharmacology; University of Oxford; Oxford, UK., Tsai YH; Laboratory of Host-Microbe Interactions and Cell Dynamics, Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Taoyuan, Taiwan; Institute of Microbiology and Immunology, College of Life Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan; Division of General Surgery, Department of Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan; Center for Molecular and Clinical Immunology, Chang Gung University, Taoyuan, Taiwan., Grimm C; Department of Pharmacology; University of Oxford; Oxford, UK; Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-Universität, Munich, Germany; Immunology, Infection and Pandemic Research IIP, Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Frankfurt, Munich, Germany., Biel M; Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians-Universität, Munich, Germany., Chen CC; Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan; Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan. Electronic address: chenchengchang@ntu.edu.tw.
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2025 Aug; Vol. 189, pp. 118350. Date of Electronic Publication: 2025 Jul 15.
Publication Type: Journal Article
Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1950-6007 (Electronic) Linking ISSN: 07533322 NLM ISO Abbreviation: Biomed Pharmacother Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1950-6007
DOI:10.1016/j.biopha.2025.118350