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TRPML2 channel modulation by PI(3,5)P₂ and small-molecule agonists controls endosomal vesicle dynamics.

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Title: TRPML2 channel modulation by PI(3,5)P₂ and small-molecule agonists controls endosomal vesicle dynamics.
Authors: Gu ZQ; Laboratory of Host-Microbe Interactions and Cell Dynamics, Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Taoyuan, Taiwan; Institute of Microbiology and Immunology, College of Life Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan., Wang HT; Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan., Li Y; Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians-Universität, Munich, Germany., Krogsaeter E; J. David Gladstone Institutes, San Francisco, CA, USA., Lin AC; Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan., Lin J; Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan., Liu YS; Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan., Lin WS; Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan., Burton W; Department of Pharmacology; University of Oxford; Oxford, UK., Liu ML; Institute of Microbiology and Immunology, College of Life Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan., Feldmann C; Institute of Cardiovascular Physiology and Pathophysiology, Vegetative Physiology, Ludwig-Maximilians-Universität, Munich, Germany., Tang R; Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-Universität, Munich, Germany., Po CW; Institute of Anatomy and Cell Biology, National Yang-Ming Chiao Tung University, Taipei, Taiwan., Hou PS; Institute of Anatomy and Cell Biology, National Yang-Ming Chiao Tung University, Taipei, Taiwan., Lin NY; Graduate Institute of Anatomy and Cell Biology, National Taiwan University College of Medicine, Taipei, Taiwan., Lin JY; Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan; Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan., Chao TL; Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan; Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians-Universität, Munich, Germany; Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan., Chang SY; Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan; Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan., Yang Z; Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians-Universität, Munich, Germany., Keller M; Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians-Universität, Munich, Germany., Leser C; Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians-Universität, Munich, Germany., Fenske S; Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians-Universität, Munich, Germany., Bracher F; Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians-Universität, Munich, Germany., Wahl-Schott C; Institute of Cardiovascular Physiology and Pathophysiology, Vegetative Physiology, Ludwig-Maximilians-Universität, Munich, Germany., Galione A; Department of Pharmacology; University of Oxford; Oxford, UK., Tsai YH; Laboratory of Host-Microbe Interactions and Cell Dynamics, Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Taoyuan, Taiwan; Institute of Microbiology and Immunology, College of Life Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan; Division of General Surgery, Department of Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan; Center for Molecular and Clinical Immunology, Chang Gung University, Taoyuan, Taiwan., Grimm C; Department of Pharmacology; University of Oxford; Oxford, UK; Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-Universität, Munich, Germany; Immunology, Infection and Pandemic Research IIP, Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Frankfurt, Munich, Germany., Biel M; Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians-Universität, Munich, Germany., Chen CC; Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan; Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan. Electronic address: chenchengchang@ntu.edu.tw.
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2025 Aug; Vol. 189, pp. 118350. Date of Electronic Publication: 2025 Jul 15.
Publication Type: Journal Article
Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1950-6007 (Electronic) Linking ISSN: 07533322 NLM ISO Abbreviation: Biomed Pharmacother Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: TRPML2 channel modulation by PI(3,5)P₂ and small-molecule agonists controls endosomal vesicle dynamics.
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  Data: <searchLink fieldCode="AU" term="%22Gu+ZQ%22">Gu ZQ</searchLink>; Laboratory of Host-Microbe Interactions and Cell Dynamics, Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Taoyuan, Taiwan; Institute of Microbiology and Immunology, College of Life Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wang+HT%22">Wang HT</searchLink>; Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians-Universität, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Krogsaeter+E%22">Krogsaeter E</searchLink>; J. David Gladstone Institutes, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lin+AC%22">Lin AC</searchLink>; Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+J%22">Lin J</searchLink>; Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Liu+YS%22">Liu YS</searchLink>; Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+WS%22">Lin WS</searchLink>; Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Burton+W%22">Burton W</searchLink>; Department of Pharmacology; University of Oxford; Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Liu+ML%22">Liu ML</searchLink>; Institute of Microbiology and Immunology, College of Life Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Feldmann+C%22">Feldmann C</searchLink>; Institute of Cardiovascular Physiology and Pathophysiology, Vegetative Physiology, Ludwig-Maximilians-Universität, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Tang+R%22">Tang R</searchLink>; Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-Universität, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Po+CW%22">Po CW</searchLink>; Institute of Anatomy and Cell Biology, National Yang-Ming Chiao Tung University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hou+PS%22">Hou PS</searchLink>; Institute of Anatomy and Cell Biology, National Yang-Ming Chiao Tung University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+NY%22">Lin NY</searchLink>; Graduate Institute of Anatomy and Cell Biology, National Taiwan University College of Medicine, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+JY%22">Lin JY</searchLink>; Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan; Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chao+TL%22">Chao TL</searchLink>; Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan; Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians-Universität, Munich, Germany; Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chang+SY%22">Chang SY</searchLink>; Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan; Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yang+Z%22">Yang Z</searchLink>; Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians-Universität, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Keller+M%22">Keller M</searchLink>; Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians-Universität, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Leser+C%22">Leser C</searchLink>; Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians-Universität, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Fenske+S%22">Fenske S</searchLink>; Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians-Universität, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Bracher+F%22">Bracher F</searchLink>; Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians-Universität, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Wahl-Schott+C%22">Wahl-Schott C</searchLink>; Institute of Cardiovascular Physiology and Pathophysiology, Vegetative Physiology, Ludwig-Maximilians-Universität, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Galione+A%22">Galione A</searchLink>; Department of Pharmacology; University of Oxford; Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Tsai+YH%22">Tsai YH</searchLink>; Laboratory of Host-Microbe Interactions and Cell Dynamics, Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Taoyuan, Taiwan; Institute of Microbiology and Immunology, College of Life Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan; Division of General Surgery, Department of Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan; Center for Molecular and Clinical Immunology, Chang Gung University, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Grimm+C%22">Grimm C</searchLink>; Department of Pharmacology; University of Oxford; Oxford, UK; Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-Universität, Munich, Germany; Immunology, Infection and Pandemic Research IIP, Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Frankfurt, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Biel+M%22">Biel M</searchLink>; Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians-Universität, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Chen+CC%22">Chen CC</searchLink>; Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan; Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan. Electronic address: chenchengchang@ntu.edu.tw.
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  Data: <searchLink fieldCode="JN" term="%228213295%22">Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie</searchLink> [Biomed Pharmacother] 2025 Aug; Vol. 189, pp. 118350. <i>Date of Electronic Publication: </i>2025 Jul 15.
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