Assessment of pharmacokinetics, safety, and neuroprotective efficacy of an adjunct intramuscular verapamil therapy in a rat model of organophosphate DFP-induced status epilepticus.

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Title: Assessment of pharmacokinetics, safety, and neuroprotective efficacy of an adjunct intramuscular verapamil therapy in a rat model of organophosphate DFP-induced status epilepticus.
Authors: Paudel YN; Departments of Neurology, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA., Blair RE; Departments of Neurology, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA., Hawkins E; Departments of Neurology, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA., Halquist MS; Departments of Pharmaceutics, Bioanalytical Shared Resource Laboratory, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298, USA., Morgan M; Departments of Pharmaceutics, Bioanalytical Shared Resource Laboratory, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298, USA., Funderburk J; Departments of Pharmaceutics, Bioanalytical Shared Resource Laboratory, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298, USA., Calvano D; Departments of Pathology, School of Medicine, Tissue and Data Acquisition and Analysis Core, VCU Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA., Koblinski J; Departments of Pathology, School of Medicine, Tissue and Data Acquisition and Analysis Core, VCU Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA., Richard H; Departments of Pathology, School of Medicine, Tissue and Data Acquisition and Analysis Core, VCU Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA., Deshpande LS; Departments of Neurology, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA.; Departments of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Jun 27. Date of Electronic Publication: 2025 Jun 27.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2692-8205
DOI:10.1101/2025.06.25.661332