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Assessment of pharmacokinetics, safety, and neuroprotective efficacy of an adjunct intramuscular verapamil therapy in a rat model of organophosphate DFP-induced status epilepticus.

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Title: Assessment of pharmacokinetics, safety, and neuroprotective efficacy of an adjunct intramuscular verapamil therapy in a rat model of organophosphate DFP-induced status epilepticus.
Authors: Paudel YN; Departments of Neurology, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA., Blair RE; Departments of Neurology, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA., Hawkins E; Departments of Neurology, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA., Halquist MS; Departments of Pharmaceutics, Bioanalytical Shared Resource Laboratory, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298, USA., Morgan M; Departments of Pharmaceutics, Bioanalytical Shared Resource Laboratory, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298, USA., Funderburk J; Departments of Pharmaceutics, Bioanalytical Shared Resource Laboratory, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298, USA., Calvano D; Departments of Pathology, School of Medicine, Tissue and Data Acquisition and Analysis Core, VCU Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA., Koblinski J; Departments of Pathology, School of Medicine, Tissue and Data Acquisition and Analysis Core, VCU Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA., Richard H; Departments of Pathology, School of Medicine, Tissue and Data Acquisition and Analysis Core, VCU Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA., Deshpande LS; Departments of Neurology, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA.; Departments of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Jun 27. Date of Electronic Publication: 2025 Jun 27.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Assessment of pharmacokinetics, safety, and neuroprotective efficacy of an adjunct intramuscular verapamil therapy in a rat model of organophosphate DFP-induced status epilepticus.
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  Data: <searchLink fieldCode="AU" term="%22Paudel+YN%22">Paudel YN</searchLink>; Departments of Neurology, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA.<br /><searchLink fieldCode="AU" term="%22Blair+RE%22">Blair RE</searchLink>; Departments of Neurology, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA.<br /><searchLink fieldCode="AU" term="%22Hawkins+E%22">Hawkins E</searchLink>; Departments of Neurology, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA.<br /><searchLink fieldCode="AU" term="%22Halquist+MS%22">Halquist MS</searchLink>; Departments of Pharmaceutics, Bioanalytical Shared Resource Laboratory, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298, USA.<br /><searchLink fieldCode="AU" term="%22Morgan+M%22">Morgan M</searchLink>; Departments of Pharmaceutics, Bioanalytical Shared Resource Laboratory, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298, USA.<br /><searchLink fieldCode="AU" term="%22Funderburk+J%22">Funderburk J</searchLink>; Departments of Pharmaceutics, Bioanalytical Shared Resource Laboratory, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298, USA.<br /><searchLink fieldCode="AU" term="%22Calvano+D%22">Calvano D</searchLink>; Departments of Pathology, School of Medicine, Tissue and Data Acquisition and Analysis Core, VCU Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA.<br /><searchLink fieldCode="AU" term="%22Koblinski+J%22">Koblinski J</searchLink>; Departments of Pathology, School of Medicine, Tissue and Data Acquisition and Analysis Core, VCU Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA.<br /><searchLink fieldCode="AU" term="%22Richard+H%22">Richard H</searchLink>; Departments of Pathology, School of Medicine, Tissue and Data Acquisition and Analysis Core, VCU Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA.<br /><searchLink fieldCode="AU" term="%22Deshpande+LS%22">Deshpande LS</searchLink>; Departments of Neurology, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA.; Departments of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA.
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  Data: <searchLink fieldCode="JN" term="%22101680187%22">BioRxiv : the preprint server for biology</searchLink> [bioRxiv] 2025 Jun 27. <i>Date of Electronic Publication: </i>2025 Jun 27.
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