A collection of patient-derived intestinal organoid lines reveals epithelial phenotypes associated with genetic drivers of pediatric inflammatory bowel disease.

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Title: A collection of patient-derived intestinal organoid lines reveals epithelial phenotypes associated with genetic drivers of pediatric inflammatory bowel disease.
Authors: Jeshvaghani ZS; Department of Pediatric Gastroenterology, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, 3584 EA, Utrecht, The Netherlands.; Regenerative Medicine Center Utrecht, University Medical Center, Utrecht University, 3584 CT, Utrecht, The Netherlands., Argmann C; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Mokry M; Department of Pediatric Gastroenterology, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, 3584 EA, Utrecht, The Netherlands.; Laboratory of Experimental Cardiology, Department of Cardiology, University Medical Center Utrecht, Utrecht University, 3584 CX, Utrecht, The Netherlands.; Laboratory of Clinical Chemistry and Haematology, University Medical Center Utrecht, 3584 CX, Utrecht, The Netherlands., van Es JH; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), and Oncode Institute, UMC Utrecht, 3584 CT, Utrecht, The Netherlands., de Vries MH; Department of Pediatric Gastroenterology, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, 3584 EA, Utrecht, The Netherlands.; Regenerative Medicine Center Utrecht, University Medical Center, Utrecht University, 3584 CT, Utrecht, The Netherlands., Collen LV; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA., Kotlarz D; Department of Pediatrics, Dr. von Hauner Children's Hospital, LMU University Hospital, 80337, Munich, Germany., Sveen M; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA., Comella P; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Snapper SB; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA., Klein C; Department of Pediatrics, Dr. von Hauner Children's Hospital, LMU University Hospital, 80337, Munich, Germany., Schadt E; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Clevers H; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), and Oncode Institute, UMC Utrecht, 3584 CT, Utrecht, The Netherlands., Kuijk E; Department of Pediatric Gastroenterology, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, 3584 EA, Utrecht, The Netherlands.; Regenerative Medicine Center Utrecht, University Medical Center, Utrecht University, 3584 CT, Utrecht, The Netherlands.; Department of Pediatrics, Lab of Cellular Disease Models, Regenerative Medicine Center Utrecht, UMC Utrecht, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands., Nieuwenhuis E; Department of Pediatric Gastroenterology, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, 3584 EA, Utrecht, The Netherlands.; Regenerative Medicine Center Utrecht, University Medical Center, Utrecht University, 3584 CT, Utrecht, The Netherlands.; Princess Maximá Center for Pediatric Oncology, 3584 CS, Utrecht, The Netherlands.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Jun 16. Date of Electronic Publication: 2025 Jun 16.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2692-8205
DOI:10.1101/2025.06.11.659052