A collection of patient-derived intestinal organoid lines reveals epithelial phenotypes associated with genetic drivers of pediatric inflammatory bowel disease.
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| Title: | A collection of patient-derived intestinal organoid lines reveals epithelial phenotypes associated with genetic drivers of pediatric inflammatory bowel disease. |
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| Authors: | Jeshvaghani ZS; Department of Pediatric Gastroenterology, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, 3584 EA, Utrecht, The Netherlands.; Regenerative Medicine Center Utrecht, University Medical Center, Utrecht University, 3584 CT, Utrecht, The Netherlands., Argmann C; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Mokry M; Department of Pediatric Gastroenterology, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, 3584 EA, Utrecht, The Netherlands.; Laboratory of Experimental Cardiology, Department of Cardiology, University Medical Center Utrecht, Utrecht University, 3584 CX, Utrecht, The Netherlands.; Laboratory of Clinical Chemistry and Haematology, University Medical Center Utrecht, 3584 CX, Utrecht, The Netherlands., van Es JH; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), and Oncode Institute, UMC Utrecht, 3584 CT, Utrecht, The Netherlands., de Vries MH; Department of Pediatric Gastroenterology, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, 3584 EA, Utrecht, The Netherlands.; Regenerative Medicine Center Utrecht, University Medical Center, Utrecht University, 3584 CT, Utrecht, The Netherlands., Collen LV; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA., Kotlarz D; Department of Pediatrics, Dr. von Hauner Children's Hospital, LMU University Hospital, 80337, Munich, Germany., Sveen M; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA., Comella P; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Snapper SB; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA., Klein C; Department of Pediatrics, Dr. von Hauner Children's Hospital, LMU University Hospital, 80337, Munich, Germany., Schadt E; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Clevers H; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), and Oncode Institute, UMC Utrecht, 3584 CT, Utrecht, The Netherlands., Kuijk E; Department of Pediatric Gastroenterology, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, 3584 EA, Utrecht, The Netherlands.; Regenerative Medicine Center Utrecht, University Medical Center, Utrecht University, 3584 CT, Utrecht, The Netherlands.; Department of Pediatrics, Lab of Cellular Disease Models, Regenerative Medicine Center Utrecht, UMC Utrecht, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands., Nieuwenhuis E; Department of Pediatric Gastroenterology, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, 3584 EA, Utrecht, The Netherlands.; Regenerative Medicine Center Utrecht, University Medical Center, Utrecht University, 3584 CT, Utrecht, The Netherlands.; Princess Maximá Center for Pediatric Oncology, 3584 CS, Utrecht, The Netherlands. |
| Source: | BioRxiv : the preprint server for biology [bioRxiv] 2025 Jun 16. Date of Electronic Publication: 2025 Jun 16. |
| Publication Type: | Journal Article; Preprint |
| Journal Info: | Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 40666956 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: A collection of patient-derived intestinal organoid lines reveals epithelial phenotypes associated with genetic drivers of pediatric inflammatory bowel disease. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Jeshvaghani+ZS%22">Jeshvaghani ZS</searchLink>; Department of Pediatric Gastroenterology, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, 3584 EA, Utrecht, The Netherlands.; Regenerative Medicine Center Utrecht, University Medical Center, Utrecht University, 3584 CT, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Argmann+C%22">Argmann C</searchLink>; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.<br /><searchLink fieldCode="AU" term="%22Mokry+M%22">Mokry M</searchLink>; Department of Pediatric Gastroenterology, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, 3584 EA, Utrecht, The Netherlands.; Laboratory of Experimental Cardiology, Department of Cardiology, University Medical Center Utrecht, Utrecht University, 3584 CX, Utrecht, The Netherlands.; Laboratory of Clinical Chemistry and Haematology, University Medical Center Utrecht, 3584 CX, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Es+JH%22">van Es JH</searchLink>; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), and Oncode Institute, UMC Utrecht, 3584 CT, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22de+Vries+MH%22">de Vries MH</searchLink>; Department of Pediatric Gastroenterology, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, 3584 EA, Utrecht, The Netherlands.; Regenerative Medicine Center Utrecht, University Medical Center, Utrecht University, 3584 CT, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Collen+LV%22">Collen LV</searchLink>; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Kotlarz+D%22">Kotlarz D</searchLink>; Department of Pediatrics, Dr. von Hauner Children's Hospital, LMU University Hospital, 80337, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Sveen+M%22">Sveen M</searchLink>; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Comella+P%22">Comella P</searchLink>; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.<br /><searchLink fieldCode="AU" term="%22Snapper+SB%22">Snapper SB</searchLink>; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Klein+C%22">Klein C</searchLink>; Department of Pediatrics, Dr. von Hauner Children's Hospital, LMU University Hospital, 80337, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Schadt+E%22">Schadt E</searchLink>; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.<br /><searchLink fieldCode="AU" term="%22Clevers+H%22">Clevers H</searchLink>; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), and Oncode Institute, UMC Utrecht, 3584 CT, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Kuijk+E%22">Kuijk E</searchLink>; Department of Pediatric Gastroenterology, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, 3584 EA, Utrecht, The Netherlands.; Regenerative Medicine Center Utrecht, University Medical Center, Utrecht University, 3584 CT, Utrecht, The Netherlands.; Department of Pediatrics, Lab of Cellular Disease Models, Regenerative Medicine Center Utrecht, UMC Utrecht, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Nieuwenhuis+E%22">Nieuwenhuis E</searchLink>; Department of Pediatric Gastroenterology, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, 3584 EA, Utrecht, The Netherlands.; Regenerative Medicine Center Utrecht, University Medical Center, Utrecht University, 3584 CT, Utrecht, The Netherlands.; Princess Maximá Center for Pediatric Oncology, 3584 CS, Utrecht, The Netherlands. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101680187%22">BioRxiv : the preprint server for biology</searchLink> [bioRxiv] 2025 Jun 16. <i>Date of Electronic Publication: </i>2025 Jun 16. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Preprint – Name: TitleSource Label: Journal Info Group: Src Data: <i>Country of Publication: </i>United States <i>NLM ID: </i>101680187 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2692-8205 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226928205%22">26928205 </searchLink><i>NLM ISO Abbreviation: </i>bioRxiv <i>Subsets: </i>PubMed not MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=40666956 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1101/2025.06.11.659052 Languages: – Code: eng Text: English Titles: – TitleFull: A collection of patient-derived intestinal organoid lines reveals epithelial phenotypes associated with genetic drivers of pediatric inflammatory bowel disease. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Jeshvaghani ZS – PersonEntity: Name: NameFull: Argmann C – PersonEntity: Name: NameFull: Mokry M – PersonEntity: Name: NameFull: van Es JH – PersonEntity: Name: NameFull: de Vries MH – PersonEntity: Name: NameFull: Collen LV – PersonEntity: Name: NameFull: Kotlarz D – PersonEntity: Name: NameFull: Sveen M – PersonEntity: Name: NameFull: Comella P – PersonEntity: Name: NameFull: Snapper SB – PersonEntity: Name: NameFull: Klein C – PersonEntity: Name: NameFull: Schadt E – PersonEntity: Name: NameFull: Clevers H – PersonEntity: Name: NameFull: Kuijk E – PersonEntity: Name: NameFull: Nieuwenhuis E IsPartOfRelationships: – BibEntity: Dates: – D: 16 M: 06 Text: 2025 Jun 16 Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 2692-8205 Titles: – TitleFull: BioRxiv : the preprint server for biology Type: main |
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