Rapid acquisition of HIV-1 neutralization breadth in a rhesus V2 apex germline antibody mouse model after a single bolus immunization.

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Title: Rapid acquisition of HIV-1 neutralization breadth in a rhesus V2 apex germline antibody mouse model after a single bolus immunization.
Authors: Ghosh AR; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, 02139, USA., Habib R; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA., Mishra N; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA., Roark RS; Aaron Diamond AIDS Research Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10027, USA., Akauliya M; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, 02139, USA., Albowaidey AA; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, 02139, USA., Allen JD; School of Biological Sciences, University of Southampton, Southampton SO17 1BJ, UK., Amereh K; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Avillion G; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA., Bottermann M; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, 02139, USA., Liang B; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Chaudhary N; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA., Callaghan S; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA., Dye J; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139 USA.; Howard Hughes Medical Institute, 29 Chevy Chase, MD 20815 USA., Li X; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Ellis-Pugh JR; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, 02139, USA., Chowdhury RR; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., James NE; School of Biological Sciences, University of Southampton, Southampton SO17 1BJ, UK., Liu X; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, 02139, USA., Maiorino L; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139 USA.; Howard Hughes Medical Institute, 29 Chevy Chase, MD 20815 USA., Maldonado P; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, 02139, USA., Nedellec R; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Oberoi P; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Sowers KJ; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Park Y; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Prum T; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, 02139, USA., Rodriguez L; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; Howard Hughes Medical Institute, 29 Chevy Chase, MD 20815 USA., Ssozi M; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, 02139, USA., Torres J; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 28 92037, USA., Walsh AA; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA., Warner JE; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, 02139, USA., Weldon SR; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, 02139, USA., Xu L; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, 02139, USA., Wiehe K; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA., Crispin M; School of Biological Sciences, University of Southampton, Southampton SO17 1BJ, UK., Ward AB; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 28 92037, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA., Nair U; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, 02139, USA., Hahn BH; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Burton DR; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, 02139, USA.; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA., Shapiro L; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10027, USA.; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA., Kwong PD; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10027, USA.; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA., Irvine DJ; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, 02139, USA.; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139 USA.; Howard Hughes Medical Institute, 29 Chevy Chase, MD 20815 USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, United States., Andrabi R; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA., Shaw GM; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Batista FD; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, 02139, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, United States.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Jun 17. Date of Electronic Publication: 2025 Jun 17.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Rapid acquisition of HIV-1 neutralization breadth in a rhesus V2 apex germline antibody mouse model after a single bolus immunization.
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  Data: <searchLink fieldCode="AU" term="%22Ghosh+AR%22">Ghosh AR</searchLink>; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, 02139, USA.<br /><searchLink fieldCode="AU" term="%22Habib+R%22">Habib R</searchLink>; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Mishra+N%22">Mishra N</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Roark+RS%22">Roark RS</searchLink>; Aaron Diamond AIDS Research Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10027, USA.<br /><searchLink fieldCode="AU" term="%22Akauliya+M%22">Akauliya M</searchLink>; 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Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, 02139, USA.<br /><searchLink fieldCode="AU" term="%22Chowdhury+RR%22">Chowdhury RR</searchLink>; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22James+NE%22">James NE</searchLink>; School of Biological Sciences, University of Southampton, Southampton SO17 1BJ, UK.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, 02139, USA.<br /><searchLink fieldCode="AU" term="%22Maiorino+L%22">Maiorino L</searchLink>; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139 USA.; Howard Hughes Medical Institute, 29 Chevy Chase, MD 20815 USA.<br /><searchLink fieldCode="AU" term="%22Maldonado+P%22">Maldonado P</searchLink>; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, 02139, USA.<br /><searchLink fieldCode="AU" term="%22Nedellec+R%22">Nedellec R</searchLink>; 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Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Crispin+M%22">Crispin M</searchLink>; School of Biological Sciences, University of Southampton, Southampton SO17 1BJ, UK.<br /><searchLink fieldCode="AU" term="%22Ward+AB%22">Ward AB</searchLink>; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 28 92037, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Nair+U%22">Nair U</searchLink>; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, 02139, USA.<br /><searchLink fieldCode="AU" term="%22Hahn+BH%22">Hahn BH</searchLink>; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Burton+DR%22">Burton DR</searchLink>; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, 02139, USA.; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Shapiro+L%22">Shapiro L</searchLink>; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10027, USA.; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA.<br /><searchLink fieldCode="AU" term="%22Kwong+PD%22">Kwong PD</searchLink>; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10027, USA.; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA.<br /><searchLink fieldCode="AU" term="%22Irvine+DJ%22">Irvine DJ</searchLink>; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, 02139, USA.; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139 USA.; Howard Hughes Medical Institute, 29 Chevy Chase, MD 20815 USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, United States.<br /><searchLink fieldCode="AU" term="%22Andrabi+R%22">Andrabi R</searchLink>; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Shaw+GM%22">Shaw GM</searchLink>; 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