Rapid acquisition of HIV-1 neutralization breadth in a rhesus V2 apex germline antibody mouse model after a single bolus immunization.
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| Title: | Rapid acquisition of HIV-1 neutralization breadth in a rhesus V2 apex germline antibody mouse model after a single bolus immunization. |
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| Authors: | Ghosh AR; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, 02139, USA., Habib R; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA., Mishra N; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA., Roark RS; Aaron Diamond AIDS Research Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10027, USA., Akauliya M; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, 02139, USA., Albowaidey AA; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, 02139, USA., Allen JD; School of Biological Sciences, University of Southampton, Southampton SO17 1BJ, UK., Amereh K; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Avillion G; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA., Bottermann M; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, 02139, USA., Liang B; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Chaudhary N; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA., Callaghan S; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA., Dye J; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139 USA.; Howard Hughes Medical Institute, 29 Chevy Chase, MD 20815 USA., Li X; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Ellis-Pugh JR; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, 02139, USA., Chowdhury RR; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., James NE; School of Biological Sciences, University of Southampton, Southampton SO17 1BJ, UK., Liu X; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, 02139, USA., Maiorino L; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139 USA.; Howard Hughes Medical Institute, 29 Chevy Chase, MD 20815 USA., Maldonado P; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, 02139, USA., Nedellec R; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Oberoi P; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Sowers KJ; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Park Y; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Prum T; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, 02139, USA., Rodriguez L; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; Howard Hughes Medical Institute, 29 Chevy Chase, MD 20815 USA., Ssozi M; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, 02139, USA., Torres J; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 28 92037, USA., Walsh AA; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA., Warner JE; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, 02139, USA., Weldon SR; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, 02139, USA., Xu L; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, 02139, USA., Wiehe K; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA., Crispin M; School of Biological Sciences, University of Southampton, Southampton SO17 1BJ, UK., Ward AB; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 28 92037, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA., Nair U; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, 02139, USA., Hahn BH; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Burton DR; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, 02139, USA.; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA., Shapiro L; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10027, USA.; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA., Kwong PD; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10027, USA.; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA., Irvine DJ; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, 02139, USA.; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139 USA.; Howard Hughes Medical Institute, 29 Chevy Chase, MD 20815 USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, United States., Andrabi R; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA., Shaw GM; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Batista FD; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, 02139, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, United States. |
| Source: | BioRxiv : the preprint server for biology [bioRxiv] 2025 Jun 17. Date of Electronic Publication: 2025 Jun 17. |
| Publication Type: | Journal Article; Preprint |
| Journal Info: | Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 40667160 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Rapid acquisition of HIV-1 neutralization breadth in a rhesus V2 apex germline antibody mouse model after a single bolus immunization. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Ghosh+AR%22">Ghosh AR</searchLink>; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, 02139, USA.<br /><searchLink fieldCode="AU" term="%22Habib+R%22">Habib R</searchLink>; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Mishra+N%22">Mishra N</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Roark+RS%22">Roark RS</searchLink>; Aaron Diamond AIDS Research Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10027, USA.<br /><searchLink fieldCode="AU" term="%22Akauliya+M%22">Akauliya M</searchLink>; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, 02139, USA.<br /><searchLink fieldCode="AU" term="%22Albowaidey+AA%22">Albowaidey AA</searchLink>; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, 02139, USA.<br /><searchLink fieldCode="AU" term="%22Allen+JD%22">Allen JD</searchLink>; School of Biological Sciences, University of Southampton, Southampton SO17 1BJ, UK.<br /><searchLink fieldCode="AU" term="%22Amereh+K%22">Amereh K</searchLink>; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Avillion+G%22">Avillion G</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Bottermann+M%22">Bottermann M</searchLink>; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, 02139, USA.<br /><searchLink fieldCode="AU" term="%22Liang+B%22">Liang B</searchLink>; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Chaudhary+N%22">Chaudhary N</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Callaghan+S%22">Callaghan S</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Dye+J%22">Dye J</searchLink>; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139 USA.; Howard Hughes Medical Institute, 29 Chevy Chase, MD 20815 USA.<br /><searchLink fieldCode="AU" term="%22Li+X%22">Li X</searchLink>; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Ellis-Pugh+JR%22">Ellis-Pugh JR</searchLink>; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, 02139, USA.<br /><searchLink fieldCode="AU" term="%22Chowdhury+RR%22">Chowdhury RR</searchLink>; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22James+NE%22">James NE</searchLink>; School of Biological Sciences, University of Southampton, Southampton SO17 1BJ, UK.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, 02139, USA.<br /><searchLink fieldCode="AU" term="%22Maiorino+L%22">Maiorino L</searchLink>; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139 USA.; Howard Hughes Medical Institute, 29 Chevy Chase, MD 20815 USA.<br /><searchLink fieldCode="AU" term="%22Maldonado+P%22">Maldonado P</searchLink>; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, 02139, USA.<br /><searchLink fieldCode="AU" term="%22Nedellec+R%22">Nedellec R</searchLink>; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Oberoi+P%22">Oberoi P</searchLink>; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Sowers+KJ%22">Sowers KJ</searchLink>; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Park+Y%22">Park Y</searchLink>; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Prum+T%22">Prum T</searchLink>; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, 02139, USA.<br /><searchLink fieldCode="AU" term="%22Rodriguez+L%22">Rodriguez L</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; Howard Hughes Medical Institute, 29 Chevy Chase, MD 20815 USA.<br /><searchLink fieldCode="AU" term="%22Ssozi+M%22">Ssozi M</searchLink>; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, 02139, USA.<br /><searchLink fieldCode="AU" term="%22Torres+J%22">Torres J</searchLink>; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 28 92037, USA.<br /><searchLink fieldCode="AU" term="%22Walsh+AA%22">Walsh AA</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Warner+JE%22">Warner JE</searchLink>; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, 02139, USA.<br /><searchLink fieldCode="AU" term="%22Weldon+SR%22">Weldon SR</searchLink>; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, 02139, USA.<br /><searchLink fieldCode="AU" term="%22Xu+L%22">Xu L</searchLink>; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, 02139, USA.<br /><searchLink fieldCode="AU" term="%22Wiehe+K%22">Wiehe K</searchLink>; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Crispin+M%22">Crispin M</searchLink>; School of Biological Sciences, University of Southampton, Southampton SO17 1BJ, UK.<br /><searchLink fieldCode="AU" term="%22Ward+AB%22">Ward AB</searchLink>; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 28 92037, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Nair+U%22">Nair U</searchLink>; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, 02139, USA.<br /><searchLink fieldCode="AU" term="%22Hahn+BH%22">Hahn BH</searchLink>; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Burton+DR%22">Burton DR</searchLink>; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, 02139, USA.; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Shapiro+L%22">Shapiro L</searchLink>; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10027, USA.; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA.<br /><searchLink fieldCode="AU" term="%22Kwong+PD%22">Kwong PD</searchLink>; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10027, USA.; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA.<br /><searchLink fieldCode="AU" term="%22Irvine+DJ%22">Irvine DJ</searchLink>; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, 02139, USA.; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139 USA.; Howard Hughes Medical Institute, 29 Chevy Chase, MD 20815 USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, United States.<br /><searchLink fieldCode="AU" term="%22Andrabi+R%22">Andrabi R</searchLink>; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Shaw+GM%22">Shaw GM</searchLink>; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Batista+FD%22">Batista FD</searchLink>; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, 02139, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, United States. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101680187%22">BioRxiv : the preprint server for biology</searchLink> [bioRxiv] 2025 Jun 17. <i>Date of Electronic Publication: </i>2025 Jun 17. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; 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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1101/2025.06.12.659380 Languages: – Code: eng Text: English Titles: – TitleFull: Rapid acquisition of HIV-1 neutralization breadth in a rhesus V2 apex germline antibody mouse model after a single bolus immunization. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Ghosh AR – PersonEntity: Name: NameFull: Habib R – PersonEntity: Name: NameFull: Mishra N – PersonEntity: Name: NameFull: Roark RS – PersonEntity: Name: NameFull: Akauliya M – PersonEntity: Name: NameFull: Albowaidey AA – PersonEntity: Name: NameFull: Allen JD – PersonEntity: Name: NameFull: Amereh K – PersonEntity: Name: NameFull: Avillion G – PersonEntity: Name: NameFull: Bottermann M – PersonEntity: Name: NameFull: Liang B – PersonEntity: Name: NameFull: Chaudhary N – PersonEntity: Name: NameFull: Callaghan S – PersonEntity: Name: NameFull: Dye J – PersonEntity: Name: NameFull: Li X – PersonEntity: Name: NameFull: Ellis-Pugh JR – PersonEntity: Name: NameFull: Chowdhury RR – PersonEntity: Name: NameFull: James NE – PersonEntity: Name: NameFull: Liu X – PersonEntity: Name: NameFull: Maiorino L – PersonEntity: Name: NameFull: Maldonado P – PersonEntity: Name: NameFull: Nedellec R – PersonEntity: Name: NameFull: Oberoi P – PersonEntity: Name: NameFull: Sowers KJ – PersonEntity: Name: NameFull: Park Y – PersonEntity: Name: NameFull: Prum T – PersonEntity: Name: NameFull: Rodriguez L – PersonEntity: Name: NameFull: Ssozi M – PersonEntity: Name: NameFull: Torres J – PersonEntity: Name: NameFull: Walsh AA – PersonEntity: Name: NameFull: Warner JE – PersonEntity: Name: NameFull: Weldon SR – PersonEntity: Name: NameFull: Xu L – PersonEntity: Name: NameFull: Wiehe K – PersonEntity: Name: NameFull: Crispin M – PersonEntity: Name: NameFull: Ward AB – PersonEntity: Name: NameFull: Nair U – PersonEntity: Name: NameFull: Hahn BH – PersonEntity: Name: NameFull: Burton DR – PersonEntity: Name: NameFull: Shapiro L – PersonEntity: Name: NameFull: Kwong PD – PersonEntity: Name: NameFull: Irvine DJ – PersonEntity: Name: NameFull: Andrabi R – PersonEntity: Name: NameFull: Shaw GM – PersonEntity: Name: NameFull: Batista FD IsPartOfRelationships: – BibEntity: Dates: – D: 17 M: 06 Text: 2025 Jun 17 Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 2692-8205 Titles: – TitleFull: BioRxiv : the preprint server for biology Type: main |
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