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Systemic delivery of biotherapeutic RNA to the myocardium transiently modulates cardiac contractility in vivo.

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Title: Systemic delivery of biotherapeutic RNA to the myocardium transiently modulates cardiac contractility in vivo.
Authors: Shuvaev VV; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104., Tam YK; Acuitas Therapeutics, Vancouver, BC V6T 1Z3, Canada., Lee BW; Cardiovascular Institute, Perelman School of Medicine, Division of Cardiology, University of Pennsylvania, Philadelphia, PA 19104., Myerson JW; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104., Herbst A; Division of Cardiothoracic Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA 19104., Kiseleva RY; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104., Glassman PM; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Department of Pharmaceutical Sciences, School of Pharmacy, Temple University, Philadelphia, PA 19140., Parhiz H; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104., Alameh MG; Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104., Pardi N; Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104., Muramatsu H; Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104., Shuvaeva TI; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104., Arguiri E; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104., Marcos-Contreras OA; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104., Hood ED; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104., Brysgel TV; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104., Nong J; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104., Papp TE; Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104., Eaton DM; Cardiovascular Institute, Perelman School of Medicine, Division of Cardiology, University of Pennsylvania, Philadelphia, PA 19104., Riley R; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104., Palanki R; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104., Musunuru K; Cardiovascular Institute, Perelman School of Medicine, Division of Cardiology, University of Pennsylvania, Philadelphia, PA 19104., Brenner JS; Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104., Mitchell MJ; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104., Ferrari VA; Cardiovascular Institute, Perelman School of Medicine, Division of Cardiology, University of Pennsylvania, Philadelphia, PA 19104., Mui BL; Acuitas Therapeutics, Vancouver, BC V6T 1Z3, Canada., Semple SC; Acuitas Therapeutics, Vancouver, BC V6T 1Z3, Canada., Weppler SA; Acuitas Therapeutics, Vancouver, BC V6T 1Z3, Canada., Atluri P; Division of Cardiothoracic Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA 19104., Margulies KB; Cardiovascular Institute, Perelman School of Medicine, Division of Cardiology, University of Pennsylvania, Philadelphia, PA 19104., Weissman D; Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104., Muzykantov VR; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Jul 22; Vol. 122 (29), pp. e2409266122. Date of Electronic Publication: 2025 Jul 16.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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Acuitas Therapeutics, Vancouver, BC V6T 1Z3, Canada.<br /><searchLink fieldCode="AU" term="%22Semple+SC%22">Semple SC</searchLink>; Acuitas Therapeutics, Vancouver, BC V6T 1Z3, Canada.<br /><searchLink fieldCode="AU" term="%22Weppler+SA%22">Weppler SA</searchLink>; Acuitas Therapeutics, Vancouver, BC V6T 1Z3, Canada.<br /><searchLink fieldCode="AU" term="%22Atluri+P%22">Atluri P</searchLink>; Division of Cardiothoracic Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Margulies+KB%22">Margulies KB</searchLink>; Cardiovascular Institute, Perelman School of Medicine, Division of Cardiology, University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Weissman+D%22">Weissman D</searchLink>; Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Muzykantov+VR%22">Muzykantov VR</searchLink>; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
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  Data: <searchLink fieldCode="JN" term="%227505876%22">Proceedings of the National Academy of Sciences of the United States of America</searchLink> [Proc Natl Acad Sci U S A] 2025 Jul 22; Vol. 122 (29), pp. e2409266122. <i>Date of Electronic Publication: </i>2025 Jul 16.
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